Abstract
Purpose: To analyze the expression of interleukin-8 in patients with post-renal insufficiency after radiotherapy of abdominal tumors.Methods: 60 patients (experimental group) with post-renal insufficiency and 30 patients (control group) without renal insufficiency after the radiotherapy for abdominal tumors were collected for case-control study. Serum interleukin-8 levels were measured before and after the cystoscopy from September 2017 to March 2019, and the relationship between interleukin-8 levels and serum creatinine, and urea nitrogen, and hydronephrosis was analyzed.Results: The level of serum interleukin-8 levels were significantly increased in patients with post-renal insufficiency after radiotherapy for abdominal tumors(P<0.05).After treatment, the level of interleukin-8 in the experimental group was significantly lower than that before the treatment (P<0.05). The expression of interleukin-8 was positively correlated with serum creatinine (r=0.297, P=0.004), but not with urea nitrogen level and hydronephrosis (r1=-0.055, P1=0.605; r2=0.116, P2=0.277). Cox proportional risk regression model showed that interleukin-8 was a high risk factor for the occurrence of post-renal insufficiency (R2=0.826, P<0.05).Conclusion: Interleukin-8 is helpful to judge the renal function of patients with abdominal tumors after radiotherapy, In the early stage of renal insufficiency, it will overexpresses, and its evaluation is better than urea nitrogen.
Risk factors and outcomes of failed endoscopic retrograde cholangiopancreatography in liver transplant recipients with anastomotic biliary strictures: A case-control study