scholarly journals Sa1965 DEVELOPMENT AND VALIDATION OF A NEW CLASSIFICATION FOR IN VIVO DIAGNOSIS OF DUODENAL EPITHELIAL TUMORS WITH CONFOCAL LASER ENDOMICROSCOPY

2018 ◽  
Vol 87 (6) ◽  
pp. AB268-AB269
Author(s):  
Tomomitsu Tahara ◽  
Noriyuki Horiguchi ◽  
Masaaki Okubo ◽  
Hyuga Yamada ◽  
Tomohiko Kawamura ◽  
...  
Keyword(s):  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
New Classification ◽  
Epithelial Tumors ◽  
In Vivo Diagnosis ◽  
Development And Validation

Development of a new classification for in vivo diagnosis of duodenal epithelial tumors with confocal laser endomicroscopy: A pilot study

2015 ◽  
Vol 28 (2) ◽  
pp. 186-193 ◽  
Author(s):  
Kouichi Nonaka ◽  
Ken Ohata ◽  
Shin Ichihara ◽  
Shinichi Ban ◽  
Yoshimitsu Hiejima ◽  
...  
Keyword(s):  
Pilot Study ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
New Classification ◽  
Epithelial Tumors ◽  
In Vivo Diagnosis

Confocal Laser Endomicroscopy for In Vivo Diagnosis of Early Squamous Cell Carcinoma in the Esophagus

2007 ◽  
Vol 65 (5) ◽  
pp. AB346 ◽  
Author(s):  
Oliver Pech ◽  
Thomas Rabenstein ◽  
Hendrik Manner ◽  
Maria C. Petrone ◽  
Juergen Pohl ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Early Squamous Cell Carcinoma ◽  
In Vivo Diagnosis

Confocal Laser Endomicroscopy for in-vivo Diagnosis of Barrett's Esophagus and Associated Neoplasia: An Ongoing Prospective Study

2008 ◽  
Vol 67 (5) ◽  
pp. AB97 ◽  
Author(s):  
Cristina Trovato ◽  
Angelica Sonzogni ◽  
Giancarla Fiori ◽  
Davide Ravizza ◽  
Darina Tamayo ◽  
...  
Keyword(s):  
Prospective Study ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
In Vivo Diagnosis

scholarly journals Development and Validation of a Confocal Laser Endomicroscopy-Based Score for In Vivo Assessment of Mucosal Healing in Ulcerative Colitis Patients

2017 ◽  
Vol 24 (1) ◽  
pp. 35-44 ◽  
Author(s):  
Gheorghe Hundorfean ◽  
Mircea T Chiriac ◽  
Sidonia Mihai ◽  
Arndt Hartmann ◽  
Jonas Mudter ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
High Sensitivity ◽  
Mucosal Healing ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Mayo Score ◽  
Before And After ◽  
Sensitivity Specificity ◽  
Development And Validation

Abstract Background Endoscopic monitoring is fundamental for evaluating the therapeutic response in IBD, but a validated endomicroscopic mucosal healing (MH) score is not available to date. However, confocal laser endomicroscopy (CLE) might define MH more precisely than conventional endoscopy. The major aim was to establish and validate an MH score for ulcerative colitis (UC), based on CLE. Methods In an initial pilot study (n = 10), various CLE changes were analyzed for identification of reproducible criteria for establishing a CLE score. Four reproducible CLE criteria were implemented in a following validation study. Subsequently, active UC patients (n = 23, Mayo score ≥6) were prospectively included and underwent colonoscopy with CLE before and after 3 anti-TNF applications. Patients were clinically followed over a period of 3 years. The endomicroscopic MH score (eMHs; range, 0–4) was compared with histopathology and endoscopy scores from the same colonic location. Results The eMHs showed high sensitivity, specificity, and accuracy values (100% with 95% confidence interval [CI] of 15.81%–100%; 93.75% with 95% CI of 69.77%–99.84%, and 94.44%, respectively). The eMHs showed a good correlation with the histological Gupta score (rs = 0.82, P < 0.0001) and the endoscopic Mayo subscore (rs = 0.81%, P < 0.0001). Sixty percent of therapy responders presented an eMHs <1, which translated into long-lasting clinical remission and reduced hospitalization, steroid, and surgery need. Conclusions CLE can accurately assess MH based on the newly developed and statistically validated eMHs in UC, and it is superior in predicting the long-lasting clinical outcome based on both descriptive and functional barrier imaging (NCT01417728).

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