Endoscopic finding of a lace pattern in a case of Epstein-Barr virus–associated early gastric carcinoma

2020 ◽  
Author(s):  
Yu Kobayashi ◽  
Hiroki Tanabe ◽  
Katsuyoshi Ando ◽  
Mikihiro Fujiya ◽  
Toshikatsu Okumura
Keyword(s):  
Gastric Carcinoma ◽  
Epstein Barr Virus ◽  
Endoscopic Finding ◽  
Early Gastric Carcinoma ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Very Low Risk of Lymph Node Metastasis in Epstein-Barr Virus-associated Early Gastric Carcinoma With Lymphoid Stroma

2020 ◽  
Author(s):  
Yuqing Cheng ◽  
Xiaoli Zhou ◽  
Kequn Xu ◽  
Jin Huang ◽  
Qin Huang
Keyword(s):  
Gastric Carcinoma ◽  
Epstein Barr Virus ◽  
Early Gastric Carcinoma ◽  
Invasion Depth ◽  
Gastric Carcinomas ◽  
Barr Virus ◽  
Node Metastasis ◽  
Lymphoid Stroma ◽  
Poor Differentiation ◽  
Epstein Barr

Abstract Epstein-Barr virus-associated early gastric carcinoma with lymphoid stroma (EBV-GCLS) is a rare variant of early gastric carcinomas. Clinicopathological features of this variant remain obscure, especially in Chinese patients. By a retrospective review of 595 consecutive radical gastrectomies for early gastric carcinoma from 2006 to 2018, we identified 8 (1.3%, 8/595) EBV-GCLS cases. Clinicopathologic characteristics were compared between EBV-GCLSs and 109 conventional early gastric carcinomas, which were divided into 3 subgroups, according to the invasion depth. All 8 EBV-GCLSs occurred in male patients and invaded deep submucosa (SM2) without lymph node metastasis (LNM), four (50%) of which had synchronous non-gastric malignant tumors (3 gastric gastrointestinal stromal tumors and 1 primary clear cell renal cell carcinoma), and four (50%) arose in the proximal stomach. Compared to conventional early gastric carcinomas, EBV-GCLS was more frequent with SM2 invasion, poor differentiation, and synchronous non-gastric carcinoma tumor, but not in age, gender, macroscopic type, location, size, perineural invasion, lymphovascular invasion, and pathologic stage. In invasion-depth stratified comparisons with the SM2 subgroup, the frequency of LNM in EBV-GCLS was significantly lower than that of conventional early gastric carcinomas ( p < 0.05) and the 5-year survival rate of patients with EBV-GCLS was better than that of conventional early gastric carcinomas in 3 subgroups (100% vs 91.5%, 85.7%, 83.9%, respectively), although the differences did not reach a statistically significant level due to the small sample size. In conclusion, Even with poor differentiation and SM2 invasion, EBV-GCLS showed very low risk of LNM and may be a candidate for endoscopic therapy.

scholarly journals Epstein-Barr virus-associated gastric carcinoma in Brazil: comparison between in situ hybridization and polymerase chain reaction detection

2012 ◽  
Vol 43 (1) ◽  
pp. 393-404 ◽  
Author(s):  
Marcos Antonio Pereira de Lima ◽  
Márcia Valéria Pitombeira Ferreira ◽  
Marcos Aurélio Pessoa Barros ◽  
Maria Inês de Moura Campos Pardini ◽  
Adriana Camargo Ferrasi ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
In Situ Hybridization ◽  
Gastric Carcinoma ◽  
Epstein Barr Virus ◽  
Polymerase Chain Reaction Detection ◽  
Chain Reaction ◽  
Barr Virus ◽  
Polymerase Chain ◽  
Epstein Barr

Phenotype analysis by MUC2, MUC5AC, MUC6, and CD10 expression in Epstein-Barr virus-associated gastric carcinoma

2006 ◽  
Vol 41 (8) ◽  
pp. 733-739 ◽  
Author(s):  
Rita Rani Barua ◽  
Hiroshi Uozaki ◽  
Ja-Mun Chong ◽  
Tetsuo Ushiku ◽  
Rumi Hino ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Phenotype Analysis ◽  
Cd10 Expression ◽  
Epstein Barr
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