Microsatellite instability and retrieval of lymph nodes in stage III colon cancer: harbinger or hermit?

2012 ◽  
Vol 43 (10) ◽  
pp. 1785-1786 ◽  
Author(s):  
Kjetil Søreide ◽  
Shuji Ogino
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Microsatellite Instability ◽  
Stage Iii ◽  
Stage Iii Colon Cancer

Microsatellite instability and retrieval of lymph nodes in stage III colon cancer: harbinger or hermit?—reply

2012 ◽  
Vol 43 (10) ◽  
pp. 1786
Author(s):  
Erin MacQuarrie ◽  
Thomas Arnason ◽  
Jennette Gruchy ◽  
Sen Yan ◽  
Arik Drucker ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Microsatellite Instability ◽  
Stage Iii ◽  
Stage Iii Colon Cancer

Should Total Number of Lymph Nodes be Used as a Quality of Care Measure for Stage III Colon Cancer?

2010 ◽  
Vol 251 (1) ◽  
pp. 184-185
Author(s):  
Jiping Wang ◽  
Mahmoud Kulaylat ◽  
James Hassett ◽  
Kelli Bullard Dunn ◽  
Merril Dayton ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Quality Of Care ◽  
Lymph Nodes ◽  
Stage Iii ◽  
Stage Iii Colon Cancer ◽  
Care Measure

Microsatellite instability status does not predict total lymph node or negative lymph node retrieval in stage III colon cancer

2012 ◽  
Vol 43 (8) ◽  
pp. 1258-1264 ◽  
Author(s):  
Erin MacQuarrie ◽  
Thomas Arnason ◽  
Jennette Gruchy ◽  
Sen Yan ◽  
Arik Drucker ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Microsatellite Instability ◽  
Stage Iii ◽  
Stage Iii Colon Cancer ◽  
Negative Lymph Node ◽  
Lymph Node Retrieval ◽  
Total Lymph Node

The role of early postoperative PET-CT in patients with pathological stage III colon cancer: Results from a large single institution study.

2017 ◽  
Vol 35 (4_suppl) ◽  
pp. 562-562
Author(s):  
Assaf Moore ◽  
Irit Ben-Aharon ◽  
Ofer Purim ◽  
Gali Perl ◽  
Olga Ulitsky ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Metastatic Disease ◽  
Stage Iii ◽  
Individual Risk ◽  
Pathological Stage ◽  
Stage Iii Colon Cancer ◽  
Pet Ct

562 Background: Current staging of patients (pts) with pathological stage III colon cancer is suboptimal; many pts still recur despite unremarkable preoperative staging work-up. We previously reported that early postoperative PET-CT can alter the stage and management of pts with high risk stage III colon cancer in up to 19% of patients. The aim of the current study was to expand the previous one to a larger cohort and to determine the role of early postoperative PET-CT in the general population of stage III colon cancer pts, regardless of their individual risk. Methods: A retrospective chart review of all consecutive pts with stage III colon cancer who underwent early postoperative PET-CT between 2007 and 2016. Demographic and clinicopathological data were collected. Results: 247 pts, 124 (50%) males, with a median age of 66 years (range, 30-92), were included. Pathological stage was IIIA, IIIB and IIIC in 18 (7.3%), 161 (65.1%) and 72 (29.1%) pts, respectively. The median number of lymph nodes retrieved was 15 (range, 6-64) and that of positive lymph nodes was 2 (range, 0-21). High FDG-uptake was observed in 52 (21.0%) pts, including 6 (2.4%) who had clear postoperative changes, 10 (4.0%) who had a false positive abnormal uptake of whom 6 underwent invasive diagnostic procedures. The PET-CT results modified the management of 36 pts (14.5%) who were found to have true positive findings: 30 (12.1%) were proven to have overt metastatic disease and in 6 (2.4%) a second primary was discovered. With the median follow-up of 39.0 months (range 7.2-98.4 months), of the 30 pts found to be metastatic, 10 (33.3%) underwent curative treatments and are currently with no evidence of disease (NED). Updated data, on more patients and a longer follow-up, will be presented at the meeting. Conclusions: Early postoperative PET-CT changed the staging and treatment of 14.5% of resected stage III pts, and has the potential for early detection of curable metastatic disease. We currently evaluate this strategy and its actual impact in a prospective trial.

Microsatellite instability as a predictor of lower relapse frequency in adjuvant chemotherapy treated stage III colon cancer patients

2004 ◽  
Vol 200 (4) ◽  
pp. 258
Author(s):  
W. Dietmaier ◽  
M. Woenckhaus ◽  
P. Ruemmele ◽  
M. Bettstetter ◽  
S. Schilling ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Adjuvant Chemotherapy ◽  
Microsatellite Instability ◽  
Cancer Patients ◽  
Stage Iii ◽  
Stage Iii Colon Cancer

Microsatellite Instability andBRAFandKRASMutations in Stage III Colon Cancer

JAMA Oncology ◽  
2016 ◽  
Vol 2 (5) ◽  
pp. 653 ◽  
Author(s):  
Dirk Klingbiel ◽  
Sabine Tejpar
Keyword(s):  
Colon Cancer ◽  
Microsatellite Instability ◽  
Stage Iii ◽  
Stage Iii Colon Cancer

Should Total Number of Lymph Nodes be Used as a Quality of Care Measure for Stage III Colon Cancer?

2009 ◽  
Vol 249 (4) ◽  
pp. 559-563 ◽  
Author(s):  
Jiping Wang ◽  
Mahmoud Kulaylat ◽  
Howard Rockette ◽  
James Hassett ◽  
Ashwani Rajput ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Quality Of Care ◽  
Lymph Nodes ◽  
Stage Iii ◽  
Stage Iii Colon Cancer ◽  
Care Measure
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