Synthesis, crystal structure and photo-induced DNA cleavage activity of ternary copper(II)-thiosemicarbazone complexes having heterocyclic bases

2004 ◽  
Vol 357 (8) ◽  
pp. 2315-2323 ◽  
Author(s):  
Anitha M. Thomas ◽  
Anil D. Naik ◽  
Munirathinam Nethaji ◽  
Akhil R. Chakravarty
Keyword(s):  
Crystal Structure ◽  
Dna Cleavage ◽  
Cleavage Activity ◽  
Dna Cleavage Activity ◽  
Thiosemicarbazone Complexes ◽  
Heterocyclic Bases

Cytotoxic copper (II) mixed ligand complexes: Crystal structure and DNA cleavage activity

2011 ◽  
Vol 46 (9) ◽  
pp. 4537-4547 ◽  
Author(s):  
Verasuntharam M. Manikandamathavan ◽  
Royapuram P. Parameswari ◽  
Thomas Weyhermüller ◽  
Hannah R. Vasanthi ◽  
Balachandran Unni Nair
Keyword(s):  
Crystal Structure ◽  
Dna Cleavage ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Cleavage Activity ◽  
Dna Cleavage Activity

scholarly journals Organoruthenium(II) thiosemicarbazone complexes: synthesis, spectral characterization, DNA binding and DNA cleavage studies

2013 ◽  
Vol 11 (6) ◽  
pp. 1010-1018 ◽  
Author(s):  
Gunasekaran Raja ◽  
Chinnasamy Jayabalakrishnan
Keyword(s):  
Elemental Analysis ◽  
13C Nmr ◽  
Dna Cleavage ◽  
Spectroscopic Studies ◽  
Spectral Studies ◽  
Mass Spectral ◽  
Cleavage Activity ◽  
Dna Cleavage Activity ◽  
Thiosemicarbazone Complexes ◽  
Ct Dna

AbstractA series of new ruthenium(II) complexes were synthesized with Schiff bases derived from salicylaldehyde / o-hydroxyacetophenone/ o-vanillin / 2-hydroxy-1-naphthaldehyde with thiosemicarbazide and acetyl furan. They are characterized by elemental analysis, IR, electronic, 1H NMR, 13C NMR and mass spectral studies. The elemental analysis suggests the stoichiometry to be 1:1 (metal:ligand). Four of these complexes were tested for its binding with CT-DNA using absorption spectroscopic studies and two of these complexes exhibit efficient DNA cleavage activity.

Synthesis, crystal structure, magnetic property and DNA cleavage activity of a new terephthalate-bridged tetranuclear copper(II) complex

Polyhedron ◽  
2007 ◽  
Vol 26 (15) ◽  
pp. 4509-4517 ◽  
Author(s):  
Koushik Dhara ◽  
Partha Roy ◽  
Jagnyeswar Ratha ◽  
Mario Manassero ◽  
Pradyot Banerjee
Keyword(s):  
Crystal Structure ◽  
Magnetic Property ◽  
Dna Cleavage ◽  
Cleavage Activity ◽  
Dna Cleavage Activity

Synthesis, crystal structure and DNA cleavage activity of a novel Ni(II)–Cd(II) coordination polymer

2009 ◽  
Vol 362 (4) ◽  
pp. 1109-1114 ◽  
Author(s):  
De-Ming Kong ◽  
Li-Na Zhu ◽  
Jiao Wang ◽  
Ya-Wei Jin ◽  
Xiao-Zeng Li ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Coordination Polymer ◽  
Dna Cleavage ◽  
Cleavage Activity ◽  
Dna Cleavage Activity

scholarly journals Synthesis, characterization and DNA cleavage activity of nickel(II) adducts with aromatic heterocyclic bases

2010 ◽  
Vol 75 (1) ◽  
pp. 61-74 ◽  
Author(s):  
Surendra Babu ◽  
Pitchika Krishna ◽  
Hussain Reddy ◽  
G.H. Philip
Keyword(s):  
Dna Cleavage ◽  
Magnetic Moments ◽  
Nuclease Activity ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Cleavage Activity ◽  
Redox Couples ◽  
Dna Cleavage Activity ◽  
Calf Thymus ◽  
Heterocyclic Bases

Mixed ligand complexes of nickel(II) with 2,4-dihydroxyacetophenone oxime (DAPO) and 2,4-dihydroxybenzophenone oxime (DBPO) as primary ligands, and pyridine (Py) and imidazole (Im) as secondary ligands were synthesized and characterized by molar conductivity, magnetic moments measurements, as well as by electronic, IR, and 1H-NMR spectroscopy. Electrochemical studies were performed by cyclic voltammetry. The active signals are assignable to the NiIII/II and NiII/I redox couples. The binding interactions between the metal complexes and calf thymus DNA were investigated by absorption and thermal denaturation. The cleavage activity of the complexes was determined using double-stranded pBR322 circular plasmid DNA by gel electrophoresis. All complexes showed increased nuclease activity in the presence of the oxidant H2O2. The nuclease activities of mixed ligand complexes were compared with those of the parent copper(II) complexes.

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