Cyclotriphosphazene-BODIPY Dyads: Synthesis, halogen atom effect on the photophysical and singlet oxygen generation properties

2020 ◽  
Vol 502 ◽  
pp. 119342 ◽  
Author(s):  
Elif Şenkuytu ◽  
Elif Okutan ◽  
Esra Tanrıverdi Eçik
Keyword(s):  
Singlet Oxygen ◽  
Halogen Atom ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Atom Effect

Achieving high singlet-oxygen generation by applying the heavy-atom effect to thermally activated delayed fluorescent materials

2021 ◽  
Author(s):  
Ya-Fang Xiao ◽  
Jia-Xiong Chen ◽  
Wen-Cheng Chen ◽  
Xiuli Zheng ◽  
Chen Cao ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Heavy Atom ◽  
Synergetic Effect ◽  
Heavy Atom Effect ◽  
Oxygen Generation ◽  
Thermally Activated ◽  
Singlet Oxygen Generation ◽  
Fluorescent Materials ◽  
Atom Effect

Applying the heavy-atom effect to TADF photosensitizers achieves ultra-high 1O2 generation (ФΔ = 0.91) by the synergetic effect of small ΔEST and considerable SOC.

Modulation of singlet oxygen generation and amphiphilic properties of trihydroxylated monohalogenated porphyrins

2015 ◽  
Vol 19 (10) ◽  
pp. 1081-1087 ◽  
Author(s):  
Derya Topkaya ◽  
Philippe Arnoux ◽  
Fabienne Dumoulin
Keyword(s):  
Singlet Oxygen ◽  
Biomedical Applications ◽  
Heavy Atom ◽  
Cell Uptake ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Halogen Atoms ◽  
Porphyrin Core ◽  
Halogen Free ◽  
Atom Effect

Two of the properties important for photodynamic therapy applications are systematically investigated on a trihydroxylated monohalogenated porphyrin core. Singlet oxygen generation can be increased thanks to the heavy atom effect, frequently provided by the introduction of halogen atoms on the photosensitizer. We compare the effect of the presence of the four halogen atoms with the analogous halogen-free porphyrin. Cell uptake is crucial as well for successful photodynamic outcome and is directly related to the amphiphilicity of the molecule. The five derivatives bearing H, F, Cl, Br or I atoms are compared in this regard. The presence of iodine atom induces a sharp difference in singlet oxygen generation compared to all the other derivatives investigated, but increases its lipophilicity, still in the limits suitable for biomedical applications.

Design of Novel Photosensitizers and Controlled Singlet Oxygen Generation for Photodynamic Therapy

2021 ◽  
Author(s):  
Esra Tanrıverdi Eçik ◽  
Onur BULUT ◽  
Hasan Hüseyin Kazan ◽  
Elif Şenkuytu ◽  
Bunyemin Cosut
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Side Effect ◽  
Side Effect Profile ◽  
High Ability ◽  
Lower Side ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Promising Strategy

Photodynamic therapy (PDT) is a promising strategy in cancer treatment with its relatively lower side effect profile. Undoubtedly, the key component of PDT is the photosensitizers with a high ability...

Biodegradable Nano-photosensitizer with Photoactivatable Singlet Oxygen Generation for Synergistic Phototherapy

2021 ◽  
Author(s):  
Jiaxin Shen ◽  
Dandan Chen ◽  
Ye Liu ◽  
Guoyang Gao ◽  
Zhihe Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Promising Method ◽  
Normal Cells ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Nir Light

Photodynamic therapy (PDT) is a promising method for cancer therapy and also may initiate unexpected damages to normal cells and tissues. Herein, we developed a near-infrared (NIR) light-activatable nanophotosensitizer, which...

Sign in / Sign up

Export Citation Format

Share Document