Low vitamin D levels are related to left ventricular concentric remodelling in men of different ethnic groups with varying cardiovascular risk

Aim. To assess vitamin D level in patients with acute coronary syndrome and to determine the relationships of vitamin D level with specific patterns of cardiovascular disease in this group of patients.Methods. 50 patients (35 (70%) males and 15 (30%) females) urgently admitted to the emergency cardiology department of Kaliningrad Regional Hospital were enrolled in the cross-sectional observational study. Patients with diabetes mellitus, autoimmune diseases and cancer were excluded from the study. The mean age of patients was 60 (55; 66) years. Cardiovascular risk factors (obesity, smoking, physical activity, alcohol consumption, genetic predisposition) were assessed in all patients. Total serum cholesterol levels, GFR (CKD-EPI) and troponin levels were measured in all participants. Echocardiography included the measurement of the left ventricular mass index. Coronary angiography with omnipaque contrast was performed in all cases. 25-OH vitamin D was measured with enzyme-linked immunosorbent assay (ELISA).Results. The majority of patients with acute coronary syndrome had vitamin D deficiency. 3 (6%) patients had severe vitamin D deficiency. The subgroup of patients with marked vitamin D deficiency (n = 39) more often had elevated blood pressure probably related to the left ventricular hypertrophy and left atrial enlargement. Left ventricular systolic dysfunction and occlusive coronary artery disease were more common in patients with lower vitamin D levels. Statistically significant correlations had not been found between vitamin D levels and cardiovascular risk factors as well as laboratory data.Conclusion. Vitamin D level below normal range was detected in the vast majority of patients with acute coronary syndrome, of them 6 % of patients had critically low vitamin D levels.

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Self medication in transpeople is not associated with deterioration in cardiovascular risk factors but is associated with reduced vitamin D levels and antidepressant use

Endocrine Abstracts ◽

10.1530/endoabs.38.p380 ◽

2015 ◽

Author(s):

Leighton Seal ◽

Fahmin Khaleque ◽

James Barrett

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Self Medication ◽

Vitamin D Levels ◽

Antidepressant Use

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Vitamin D levels in two ethnic groups of patients with diabetes

Endocrine Abstracts ◽

10.1530/endoabs.56.p202 ◽

2018 ◽

Author(s):

Georgios Papadakis ◽

Thomas Zambelis ◽

Kostas Konstantopoulos ◽

Stylianos Chatzipanagiotou

Keyword(s):

Vitamin D ◽

Ethnic Groups ◽

Vitamin D Levels ◽

Patients With Diabetes

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Are soluble ST2 levels influenced by vitamin D and/or the seasons?

Endocrine Connections ◽

10.1530/ec-19-0090 ◽

2019 ◽

Vol 8 (6) ◽

pp. 691-700

Author(s):

Vito Francic ◽

Martin Keppel ◽

Verena Schwetz ◽

Christian Trummer ◽

Marlene Pandis ◽

...

Keyword(s):

Vitamin D ◽

Cardiovascular Risk ◽

Cardiovascular Health ◽

Health Study ◽

Cardiovascular Health Study ◽

Disease Manifestation ◽

Cross Sectional ◽

Soluble St2 ◽

Vitamin D Levels ◽

Cardiovascular Biomarker

Objective Cardiovascular disease manifestation and several associated surrogate markers, such as vitamin D, have shown substantial seasonal variation. A promising cardiovascular biomarker, soluble ST2 (sST2), has not been investigated in this regard – we therefore determined if systemic levels of sST2 are affected by seasonality and/or vitamin D in order to investigate their clinical interrelation and usability. Design sST2 levels were measured in two cohorts involving hypertensive patients at cardiovascular risk, the Styrian Vitamin D Hypertension Trial (study A; RCT design, 8 weeks 2800 IU cholecalciferol daily) and the Ludwigshafen Risk and Cardiovascular Health Study (LURIC; study B; cross-sectional design). Methods The effects of a vitamin D intervention on sST2 levels were determined in study A using ANCOVA, while seasonality of sST2 levels was determined in study B using ANOVA. Results The concentrations of sST2 remained unchanged by a vitamin D intervention in study A, with a mean treatment effect (95% confidence interval) of 0.1 (−0.6 to 0.8) ng/mL; P = 0.761), despite a rise in 25(OH)D (11.3 (9.2–13.5) ng/mL; P < 0.001) compared to placebo. In study B, seasonal variations were present in 25(OH)D levels in men and women with or without heart failure (P < 0.001 for all subgroups), while sST2 levels remained unaffected by the seasons in all subgroups. Conclusions Our study provides the first evidence that systemic sST2 levels are not interrelated with vitamin D levels or influenced by the seasons in subjects at cardiovascular risk.

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Association of Serum Parathyroid Hormone and Vitamin D Levels with Cardiovascular Risk Factors

Korean Journal of Family Practice ◽

10.21215/kjfp.2017.7.1.55 ◽

2017 ◽

Vol 7 (1) ◽

pp. 55-59

Author(s):

Seong-Gun Shin ◽

Seon-Ki Park ◽

Kyung-Min Kim ◽

Dong-Hui Kim

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Cardiovascular Risk ◽

Parathyroid Hormone ◽

Cardiovascular Risk Factors ◽

Serum Parathyroid Hormone ◽

Vitamin D Levels

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Vitamin D and Cardiovascular Risk: Which Implications in Children?

International Journal of Molecular Sciences ◽

10.3390/ijms21103536 ◽

2020 ◽

Vol 21 (10) ◽

pp. 3536 ◽

Cited By ~ 3

Author(s):

Silvia Savastio ◽

Erica Pozzi ◽

Francesco Tagliaferri ◽

Roberta Degrandi ◽

Roberta Cinquatti ◽

...

Keyword(s):

Vitamin D ◽

Cardiovascular Risk ◽

Pediatric Patients ◽

Cardiovascular Effects ◽

Vitamin D Supplementation ◽

Risk Markers ◽

Randomized Controlled ◽

Increased Risk ◽

Vitamin D Levels ◽

Lipid Parameters

Vitamin D (25OHD) pleiotropic effects are widely recognized and studied. Recently, vitamin D cardiovascular effects are gaining interest, especially in children, although the studies present conflicting data. Some randomized controlled trials (RCTs) have demonstrated that cardiovascular risk markers, such as lipid parameters, inflammation markers, blood pressure, and arterial stiffness, are unaffected by vitamin D supplementation. By contrast, other studies show that low vitamin D levels are associated with higher risk of cardiovascular disease (CVD) and mortality, and support that increased risk of these diseases occurs primarily in people with vitamin D deficiency. An update on these points in pediatric patients is certainly of interest to focus on possible benefits of its supplementation.

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