Genetic variants in TNFα and the one-year cardiovascular outcome in patients with coronary heart disease

2013 ◽  
Vol 168 (2) ◽  
pp. 1688-1690 ◽  
Author(s):  
Susanne Schulz ◽  
Axel Schlitt ◽  
Andrea Lutze ◽  
Sandra Lischewski ◽  
Tim Seifert ◽  
...  
2015 ◽  
Vol 372 (3) ◽  
pp. 295-296 ◽  
Author(s):  
Linda M. Polfus ◽  
Richard A. Gibbs ◽  
Eric Boerwinkle

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e27481 ◽  
Author(s):  
Li Zhou ◽  
Hu Ding ◽  
Xiaomin Zhang ◽  
Meian He ◽  
Suli Huang ◽  
...  

Data in Brief ◽  
2016 ◽  
Vol 8 ◽  
pp. 1295-1299
Author(s):  
Stefan Reichert ◽  
Axel Schlitt ◽  
Ann-Christin Benten ◽  
Britt Hofmann ◽  
Hans-Günter Schaller ◽  
...  

1991 ◽  
Vol 68 (3_suppl) ◽  
pp. 1059-1066 ◽  
Author(s):  
Esther R. Greenglass ◽  
Juhani Julkunen

According to research, hostility is a reliable predictor of coronary heart disease. Cook-Medley-defined hostility in particular has been seen as a significant precursor of coronary disease. It is important to specify the kind of hostility measured by the Cook-Medley scale. The present study examined the construct validity of the Cook-Medley scale for a sample of 219 university students in Finland, a country with a high incidence of coronary heart disease. The results supported the interpretation of the Cook-Medley scale primarily as a measure of cynicism and distrust. On the basis of our previous research, a subscale of the Cook-Medley scale was formed. This 9-item scale, a measure of Cynical Distrust, correlated positively with cynicism and negatively with trust. Moreover, the over-all pattern of correlations between the new 9-item factor, cynical distrust, and other variables assessing hostility, anger, and trust, was similar to the one obtained for our previous sample of students. It is suggested that this new 9-item scale is a shorter and more specific alternative to the longer Cook-Medley scale as a measure of cynical distrust.


2019 ◽  
Author(s):  
Anita Kärner Köhler ◽  
Tiny Jaarsma ◽  
Pia Tingström ◽  
Staffan Nilsson

Abstract Background The hypothesis tested was that one year of problem-based learning (PBL) improves patients’ self-efficacy, and empowerment to change self-care significantly compared to one year of standardised home-sent patient information after an event of coronary heart disease (CHD). Methods We randomly assigned 157 patients (78% male; age 68±8.5 years) with CHD verified by percutaneous coronary intervention (PCI) (70.1%) or coronary artery by-pass surgery (CABG) and CABG+PCI or myocardial infarction (29.9%) to either PBL (experimental group; n = 79) or home-sent patient information group (controls; n = 78). The PBL intervention consisted of a patient education in primary health care by trained district nurses who tutored groups of 6-9 patients on 13 occasions over one year. Controls received home- sent patient information on 11 occasions during the study year. Results At the one-year follow-up, the primary outcome, patient empowerment, did not significantly differ between the experimental group and controls. We found no significant differences between the groups regarding the secondary outcomes e.g. self-efficacy, although we found significant differences for body mass index (BMI) [-0.17 (SD 1.5) vs. 0.50 (SD 1.6), P=0.033 ], body weight [-0.83 (SD 4.45 vs. 1.14 kg (SD 4.85), P=0.026 ] and HDL cholesterol [0.1 (SD 0.7) vs. 0.0 mmol/L (SD 0.3), P=0.038 ] for the experimental group compared to controls. Conclusions The PBL and the home-sent patient information interventions had similar results regarding patient empowerment. However, PBL exhibited significant effects on weight loss, BMI, and HDL cholesterol levels, indicating that the PBL intervention positively affected risk factors compared to the home-sent patient information intervention. Trial registration : NCT01462799 (August 2019, date last accessed) Keywords: Problem-based learning, Coronary Heart Disease, Primary Health Care, Patient empowerment, Risk factors, Self-care


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