scholarly journals Epidemiology of Enterobacteriaceae with reduced susceptibility to third-generation cephalosporins isolated from stool screening at entry to a tertiary care hospital

2008 ◽  
Vol 12 ◽  
pp. e358
Author(s):  
J. Chan ◽  
D. Lye ◽  
Y.S. Leo ◽  
T.H. Koh ◽  
W.Y. Tang ◽  
...  
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Third Generation ◽  
Third Generation Cephalosporins

Epidemiology of nosocomial infections in medicine intensive care unit at a tertiary care hospital in northern India

2008 ◽  
Vol 38 (4) ◽  
pp. 233-235 ◽  
Author(s):  
Shabina Habibi ◽  
Naveet Wig ◽  
Sunil Agarwal ◽  
Surendra K Sharma ◽  
Rakesh Lodha ◽  
...  
Keyword(s):  
Intensive Care ◽  
Nosocomial Infections ◽  
Prospective Observational Study ◽  
Tertiary Care Hospital ◽  
Blood Stream Infection ◽  
Tertiary Care ◽  
Blood Stream ◽  
Care Hospital ◽  
Northern India ◽  
Third Generation Cephalosporins

This prospective observational study describes the rates of nosocomial infections (NI), the sites of infection, the pathogens involved, their antibiogram and the risk factors at a tertiary care hospital in northern India. In 62 of the 182 enrolled patients 95 episodes of NI were recorded (incidence rate 28.6/1000 person days): pneumonia (77%); urinary tract infection (24%) and blood stream infection (24%). All isolates of Acinetobacter, Pseudomonas and Klebsiella and 83.3% of Escherichia coli were resistant to the third generation cephalosporins. An increased duration of the time spent in intensive care units and days of intervention were associated with incident NI.

scholarly journals Third-Generation Cephalosporin-Resistant Spontaneous Bacterial Peritonitis: A single-Centre Experience and Summary of Existing Studies

2014 ◽  
Vol 28 (2) ◽  
pp. 83-88 ◽  
Author(s):  
Jennifer Chaulk ◽  
Michelle Carbonneau ◽  
Hina Qamar ◽  
Adam Keough ◽  
Hsiu-Ju Chang ◽  
...  
Keyword(s):  
Spontaneous Bacterial Peritonitis ◽  
Tertiary Care ◽  
Generation Cephalosporin ◽  
Care Hospital ◽  
Third Generation ◽  
Bacterial Peritonitis ◽  
Common Diagnosis ◽  
Cephalosporin Resistance ◽  
Third Generation Cephalosporins ◽  
Culture Positive

BACKGROUND: Spontaneous bacterial peritonitis (SBP) is the most prevalent bacterial infection in patients with cirrhosis. Although studies from Europe have reported significant rates of resistance to third-generation cephalosporins, there are limited SBP-specific data from centres in North America.OBJECTIVE: To evaluate the prevalence of, predictors for and clinical impact of third-generation cephalosporin-resistant SBP at a Canadian tertiary care centre, and to summarize the data in the context of the existing literature.METHODS: SBP patients treated with both antibiotics and albumin therapy at a Canadian tertiary care hospital between 2003 and 2011 were retrospectively identified. Multivariate logistic regression was used to determine independent predictors of third-generation cephalosporin resistance and mortality.RESULTS: In 192 patients, 25% of infections were nosocomial. Forty per cent (77 of 192) of infections were culture positive; of these, 19% (15 of 77) were resistant to third-generation cephalosporins. The prevalence of cephalosporin resistance was 8% with community-acquired infections, 17% with health care-associated infections and 41% with nosocomial acquisition. Nosocomial acquisition of infection was the only predictor of resistance to third-generation cephalosporins (OR 4.0 [95% CI 1.04 to 15.2]). Thirty-day mortality censored for liver transplantation was 27% (50 of 184). In the 77 culture-positive patients, resistance to third-generation cephalosporins (OR 5.3 [1.3 to 22]) and the Model for End-stage Live Disease score (OR 1.14 [1.04 to 1.24]) were independent predictors of 30-day mortality.CONCLUSIONS: Third-generation cephalosporin-resistant SBP is a common diagnosis and has an effect on clinical outcomes. In an attempt to reduce the mortality associated with resistance to empirical therapy, high-risk subgroups should receive broader empirical antibiotic coverage.

Emergence of Third generation Cephalosporin Resistant Escherichia coli in infants: Retrospective Study from a Tertiary Care Hospital in South India

2020 ◽  
Vol 18 ◽  
Author(s):  
Santhosh J. Thattil ◽  
Thekkuttuparambil A. Ajith
Keyword(s):  
Retrospective Study ◽  
Tertiary Care Hospital ◽  
Throat Swab ◽  
Tertiary Care ◽  
Generation Cephalosporin ◽  
Urine Samples ◽  
Care Hospital ◽  
Third Generation ◽  
E Coli ◽  
Sensitivity Pattern

Aim: This study was aimed to evaluate the emergence of third generation cephalosporin resistant Escherichiacoli isolated from the culture of various biological fluids of infants in a tertiary care hospital. Background: :Resistance to commonly used antibiotics is consistently increasing during the last decades and it was found varying with time and geographical location. Objectives: To determine the prevalence of third generation cephalosporin sensitivity pattern of E. coli isolated from urine, stool, and throat swab culture from laboratory records. Methods: Retrospective study included the laboratory report of antibiotic sensitivity conducted on infants specimens during the period of 2 years. Third generation cephalosporin sensitivity pattern of E. coli isolated from urine, stool, and throat swab culture were collected and data were statistically analyzed. Results: Reports of 351 samples with positive E. coli were included in the study. More samples were analyzed from infants above 6 months of age with female dominance (184/351). Among the specimens tested, urine samples were highest 128/351 (35.0%). Cephalosporin resistant strain was found in 243/351 samples (69.2%) (p=0.0463) with 218/243 (89.7%) isolated from infants above 6 months of age and 25/243 (10.2%) were from infants below 6 months of age (p=0.038). The frequency of cephalosporin resistant E.coli in urine specimens of male and female infants was significant (p=0.0001). Conclusion: Third generation cephalosporin resistant E. coli strain was found in 69.2% of isolates and more in urine samples from female infants above 6 months of age. The clinicians should consider the emergence of cephalosporin resistantE. coli while selecting antibiotics as the empirical treatment.

Necrotising otitis externa: clinical profile and management protocol

2013 ◽  
Vol 127 (11) ◽  
pp. 1071-1077 ◽  
Author(s):  
D V Lambor ◽  
C P Das ◽  
H C Goel ◽  
M Tiwari ◽  
S D Lambor ◽  
...  
Keyword(s):  
Otitis Externa ◽  
Tertiary Care ◽  
Management Policy ◽  
Treatment Modalities ◽  
Care Hospital ◽  
Third Generation ◽  
Hospital Data ◽  
Management Protocol ◽  
High Index Of Suspicion ◽  
Third Generation Cephalosporins

AbstractBackground:Necrotising otitis externa, which is typically seen in elderly diabetics, is a severe infective disorder caused byPseudomonas aeruginosa. There is lack of standard management policy for necrotising otitis externa, hence this study attempted to frame a protocol for management based on clinical parameters.Method:A retrospective study of 27 patients with necrotising otitis externa was conducted over 6 years in a tertiary care hospital. Data were analysed with regards to demographic characteristics, clinical features, investigations, staging and treatment modalities.Results:Out of 27 patients, 26 were diabetics. The commonest organism isolated wasP aeruginosa, which was sensitive to third generation cephalosporins and fluoroquinolones. Nine patients had cranial nerve involvement. Twelve of 15 patients treated with medical therapy recovered, as did 11 of 12 patients that underwent surgery.Conclusion:A high index of suspicion, early diagnosis and prompt intervention are key factors to decrease morbidity and mortality. Fluoroquinolones, third generation cephalosporins and surgical debridement are the mainstay of treatment.

Confidence toward vaccination as reported by parents of children admitted to a tertiary care hospital in Riyadh, Saudi Arabia: A cross sectional study

Vacunas ◽  
2020 ◽  
Vol 21 (2) ◽  
pp. 95-104 ◽  
Author(s):  
Y.M. AlGoraini ◽  
N.N. AlDujayn ◽  
M.A. AlRasheed ◽  
Y.E. Bashawri ◽  
S.S. Alsubaie ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional
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