Tannate complexes of antihistaminic drug: Sustained release and taste masking approaches

2012 ◽  
Vol 422 (1-2) ◽  
pp. 91-100 ◽  
Author(s):  
Ziyaur Rahman ◽  
Ahmed S. Zidan ◽  
Robert T. Berendt ◽  
Mansoor A. Khan
Keyword(s):  
Sustained Release ◽  
Taste Masking ◽  
Drug Sustained Release ◽  
Tannate Complexes ◽  
Antihistaminic Drug

Formulation and Evaluation of Mefloquine Hydrochloride Nanoparticles

2014 ◽  
Vol 7 (1) ◽  
pp. 2377-2386
Author(s):  
Dilip Kumar Gupta ◽  
B K Razdan ◽  
Meenakshi Bajpai
Keyword(s):  
Particle Size ◽  
Sustained Release ◽  
In Vitro Release ◽  
Entrapment Efficiency ◽  
Taste Masking ◽  
Diffusion Method ◽  
Drug Entrapment Efficiency ◽  
Resistant Strains ◽  
Vitro Release

The present study deals with the formulation and evaluation of mefloquine hydrochloride nanoparticles. Mefloquine is a blood schizonticidal quinoline compound, which is indicated for the treatment of mild-to-moderate acute malarial infections caused by mefloquine-susceptible multi-resistant strains of P. falciparum and P. vivax. The purpose of the present work is to minimize the dosing frequency, taste masking toxicity and to improve the therapeutic efficacy by formulating mefloquine HCl nanoparticles. Mefloquine nanoparticles were formulated by emulsion diffusion method using polymer poly(ε-caprolactone) with six different formulations. Nanoparticles were characterized by determining its particle size, polydispersity index, drug entrapment efficiency, drug content, particle morphological character and drug release. The particle size ranged between 100 nm to 240 nm. Drug entrapment efficacy was >95%. The in-vitro release of nanoparticles were carried out which exhibited a sustained release of mefloquine HCl from nanoparticles up to 24 hrs. The results showed that nanoparticles can be a promising drug delivery system for sustained release of mefloquine HCl.

Cholorpheniramine tannate complexes: Physicochemical, chemometric, and taste masking evaluation

2012 ◽  
Vol 436 (1-2) ◽  
pp. 582-592 ◽  
Author(s):  
Ziyaur Rahman ◽  
Ahmed S. Zidan ◽  
Saeed R. Khan ◽  
Indra K. Reddy ◽  
Mansoor A. Khan
Keyword(s):  
Taste Masking ◽  
Tannate Complexes

Electrospun progesterone‐loaded cellulose acetate nanofibers and their drug sustained‐release profiles

2020 ◽  
Vol 60 (12) ◽  
pp. 3231-3243
Author(s):  
Gabriella Onila do Nascimento Soares ◽  
Raíssa Ribeiro Lima Machado ◽  
Mariana Mendonça Diniz ◽  
Aline Bruna da Silva
Keyword(s):  
Sustained Release ◽  
Cellulose Acetate ◽  
Drug Sustained Release ◽  
Release Profiles

Polydiacetylene vesicles as a novel drug sustained-release system

2010 ◽  
Vol 76 (1) ◽  
pp. 362-365 ◽  
Author(s):  
Caixin Guo ◽  
Shaoqin Liu ◽  
Zhifei Dai ◽  
Chang Jiang ◽  
Wenyuan Li
Keyword(s):  
Sustained Release ◽  
Release System ◽  
Drug Sustained Release ◽  
Novel Drug

Preparation, Characterization and In Vitro Evaluation of IVM Loaded Poly(lactic-Co-Glycolic Acid) (PLGA) Microspheres

2011 ◽  
Vol 311-313 ◽  
pp. 1751-1754
Author(s):  
Gui Yu Li ◽  
Xi Hong Lu ◽  
Xue Hu Li ◽  
Lei Tao ◽  
Jian Ping Liang
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
High Performance ◽  
Glycolic Acid ◽  
Drug Release Profile ◽  
Release Formulation ◽  
Sustained Release Formulation ◽  
Drug Delivery Carrier ◽  
Drug Sustained Release

Drug was encapsulated in a novel copolymers of poly(lactic-co-glycolic acid) (PLGA) to investigate the sustained-release formulation of drug loaded polymer microspheres delivery system. Used a modified solid-in-oil-in-water (S/O/W) emulsion solvent evaporation method to prepare microspheres, its morphology and particle size distribution were estimated by scanning electron microscopy (SEM), the profile of in vitro drug release were assessed by High performance liquid chromatography (HPLC). Finally, an stable release buffer was utilized to obtain a detailed drug release profile, which was analyzed by HPLC also. Results showed that the microspheres morphology, encapsulation efficiency and the cumulative drug release efficiency were appropriate for veterinary medicine using. The modified preparation method was simple and optimized, PLGA microspheres with excellent controlled-release characteristics may serve as drug delivery carrier and may prolong the drug sustained-release effect.

scholarly journals Ion-exchange complex of famotidine: sustained release and taste masking approach of stable liquid dosage form

2014 ◽  
Vol 8 (6) ◽  
pp. 268-275 ◽  
Author(s):  
Reham Mokhtar Aman ◽  
Mahasen Mohamed Meshali ◽  
Galal Mahmoud Abdelghani
Keyword(s):  
Ion Exchange ◽  
Sustained Release ◽  
Dosage Form ◽  
Taste Masking ◽  
Exchange Complex ◽  
Liquid Dosage Form
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