Polymeric coatings for a multiple-unit pulsatile delivery system: Preliminary study on free and applied films

2013 ◽  
Vol 440 (2) ◽  
pp. 256-263 ◽  
Author(s):  
Alessandra Maroni ◽  
Maria Dorly Del Curto ◽  
Matteo Cerea ◽  
Lucia Zema ◽  
Anastasia Foppoli ◽  
...  
Keyword(s):  
Delivery System ◽  
Polymeric Coatings ◽  
Multiple Unit ◽  
Preliminary Study ◽  
Pulsatile Delivery

A Concise Insight on Pulsatile Drug Delivery System: An Outlook towards its Development

2021 ◽  
Vol 14 (5) ◽  
pp. 5577-5587
Author(s):  
Om M Bagade ◽  
Snehal S Sutar ◽  
Priyanka E Doke
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Patient Compliance ◽  
Delivery System ◽  
The Body ◽  
Multiple Unit ◽  
Pulsatile Drug Delivery ◽  
Pulsatile Delivery ◽  
Time Specific ◽  
The Right

In pharmaceutical science, the pulsatile drug delivery system gains more attraction because of their number of benefits over the other dosage forms. In these systems, the drug is released at right time at the right site of action, and in the right amount, it is the most beneficial and important characteristic of the PDDS system due to that the patient compliance is increased, and the drug release is after a well-defined lag time.  Moreover, this system is designed according to the circadian rhythm of the body. Because the disease has a predictable cyclic rhythm, such as Arthritis, diabetes mellitus, asthma, peptic ulcer, hypertension, cardiovascular disease the PDDS is more effective than other dosage forms.This system is a more time-specific and site-specific drug delivery system. In this system the drug is released as a pulse. The mechanism of PDDS is first diffusion then erosion and then osmosis. For the drug having a high first-pass effect and having a high risk of toxicity and side effects, these systems can be very useful. And to reduce dosing frequency and improve patient compliance this system is very helpful. There are various methods present like, single-unit systems and multiple-unit systems – which included capsular system, pulsatile delivery by osmosis, pulsatile delivery by erosion of membrane, delivery by rupture of membrane, etc.  

Preparation and Evaluation of a Gas Formation-based Multiple-Unit Gastro-Retentive Floating Delivery System of Dipyridamole

2012 ◽  
Vol 5 (1) ◽  
pp. 1607-1616
Author(s):  
Y. Madhusudan Rao ◽  
Katakam V V ◽  
S Reddy ◽  
J M Somagoni ◽  
P K Panakanti ◽  
...  
Keyword(s):  
Drug Release ◽  
Delivery System ◽  
Polymeric Membrane ◽  
Wet Granulation ◽  
Physical Parameters ◽  
Gastric Residence Time ◽  
Gas Formation ◽  
Multiple Unit ◽  
Model Drug

The aim of this study was to prepare mini tablets to be filled into a capsule that is designed to float on the gastric contents based on gas formation technique. The drug-containing core mini-tablets were prepared by wet granulation method followed by a coating of the core units with seal coating, an effervescent layer and a gas-entrapping polymeric membrane (Eudragit RS30D, RL30D). Dipyridamole, which is predominantly absorbed in the upper part of GI tract and unabsorbed/insoluble at the lower intestine, was used as a model drug. The effect of the preparative parameters like amount of the effervescent agent layered onto the seal coated units, type and coating level of the gas-entrapping polymeric membrane, floating ability and drug release properties of the multiple-unit FDDS were evaluated. The formulations were evaluated for pharmacopoeial quality control tests. Physical parameters were found to be within the acceptable limits. The system using Eudragit® RL30D as a gas-entrapping polymeric membrane exhibited floating properties. The time to float decreased as amount of the effervescent agent increased and coating level of gas-entrapping polymeric membrane decreased. The optimum system exhibited complete floating within 3 minutes and maintained that buoyancy over a period of 8 hours. The drug release was sustained and linear with the square root of time. Increasing the coating level of the gas-entrapping polymeric membrane decreased drug release. Both the rapid-floating and sustained-release properties were achieved in the multiple-unit floating delivery system developed in this study. The in vivo gastric residence time was examined by radiograms and it was found that the units remained in the stomach for about 6 hours. The analysis of the dissolution data after storage at 40°C and 75% RH for 6 months showed no significant change indicating good stability.

Dissolution and Pharmacokinetic Properties of Alkaloids and Flavonoids in a Xiexin Multiple-unit Drug Delivery System

Drug Research ◽  
2013 ◽  
Vol 63 (10) ◽  
pp. 501-509 ◽  
Author(s):  
Y. Xie ◽  
Y. Hu ◽  
M. Shen ◽  
Y. Ma ◽  
J. Zhong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Pharmacokinetic Properties ◽  
Multiple Unit

scholarly journals Preliminary Study for a Newly Designed Silicone Stent and Delivery System for Canine Obstructive Tracheal Disease

2012 ◽  
Vol 74 (10) ◽  
pp. 1323-1326 ◽  
Author(s):  
Dae-Hyun KIM ◽  
Chi-Bong CHOI ◽  
Wook-Hun CHUNG ◽  
Sung-Ho LEE ◽  
A-Jin LEE ◽  
...  
Keyword(s):  
Delivery System ◽  
Silicone Stent ◽  
Tracheal Disease ◽  
Preliminary Study

A Preliminary Study of Crosslinked Alginate-Chitosan Microspheres for Delivery System

2014 ◽  
Vol 887-888 ◽  
pp. 520-523 ◽  
Author(s):  
Jie Zhou ◽  
Yuan Lu Cui ◽  
Yun Qi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Loading ◽  
Site Specificity ◽  
Colonic Drug Delivery ◽  
Bonding Interaction ◽  
Preliminary Study ◽  
Potential Use

Glutaraldehyde cross-linked chitosan coated-alginate microspheres were prepared to improve site specificity in colonic drug delivery system. Microspheres were characterized by microscopic image analysis, DSC and IR to study the formation of microspheres structure as well as the chemical interactions between drug and polymer. Microscope observation showed good spherical and homogeneous of microspheres. The glutaraldehyde cross-linked microspheres could produce Schiff base reaction and decrease chitosan hydrogen bonding interaction with mucous membrane. The drug loading of chitosan coated-alginate microspheres reached 43% and in vitro release properties of microspheres without cecal contents reached 20.96% after 12 h. The release profiles indicated that microsphere has a satisfactory sustained release behavior. Glutaraldehyde cross-linked chitosan coated-alginate microspheres have a great potential use in drug delivery system.

Sign in / Sign up

Export Citation Format

Share Document