Polymeric-based drug delivery systems for veterinary use: State of the art

2021 ◽  
pp. 120756
Author(s):  
Suzana Gonçalves Carvalho ◽  
Amanda Letícia Polli Silvestre ◽  
Aline Martins dos Santos ◽  
Bruno Fonseca-Santos ◽  
Winner Duque Rodrigues ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
State Of The Art ◽  
Delivery Systems

Chitosan Nanoparticles: An Approbative System for the Delivery of Herbal Bioactives

2020 ◽  
Vol 10 ◽  
Author(s):  
Sapna Saini ◽  
Sanju Nanda ◽  
Anju Dhiman
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
State Of The Art ◽  
Chitosan Nanoparticles ◽  
Delivery Systems ◽  
Intrinsic Properties ◽  
Amino Groups ◽  
Suitable Candidate ◽  
Film Forming ◽  
Novel Drug

: Chitosan, a natural biodegradable polymer obtained from deacetylation of chitin, has been used as an approbative macromolecule for the development of various novel drug delivery systems. It is one of the most favorable biodegradable carriers for nanoparticulate drug delivery due to its intrinsic properties, such as biocompatibility, biodegradability, non-toxicity, availability of free reactive amino groups, and ease of chemical modification into different active derivatives. Furthermore, interesting physical properties (film-forming, gelling and thickening) make it a suitable candidate for formulations, such as films, microcapsules, beads, nanoparticles, nanofibres, nanogel and so on. Researchers have reported that chitosan nanoparticles act as a promising vehicle for herbal actives as they provide a superior alternative to traditional carriers and improve pharmaceutical efficiency. As no review of chitosan nanoparticles encapsulating herbal extracts and bioactives has been published till date, a maiden effort has been made to collate and review the use of chitosan nanoparticles for the entrapment of phytoconstituents to yield stable, efficient and safe drug delivery systems. Additionally, the paper presents a comprehensive account of the state-of the-art in fabricating herbal chitosan nanoparticles and their current pharmacological status. A list of patents on chitosan nanoparticles of herbal actives has also been included. This review is intended to serve as a didactic discourse for the formulation scientists endeavoring to develop advanced delivery systems for herbal actives.

Bioresponsive drug delivery systems in intestinal inflammation: State-of-the-art and future perspectives

2019 ◽  
Vol 146 ◽  
pp. 248-266 ◽  
Author(s):  
Niranjan G. Kotla ◽  
Shubhasmin Rana ◽  
Gandhi Sivaraman ◽  
Omprakash Sunnapu ◽  
Praveen K. Vemula ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Intestinal Inflammation ◽  
State Of The Art ◽  
Delivery Systems ◽  
Future Perspectives

scholarly journals Bio-Inspired Polymer-Polymer Hybrids for Medical Applications

2021 ◽  
Author(s):  
Gokhan Demirci ◽  
Malwina Niedzwiedz ◽  
Nina Kantor-Malujdy ◽  
Miroslawa El Fray
Keyword(s):  
Drug Delivery ◽  
Hybrid Systems ◽  
Drug Delivery Systems ◽  
State Of The Art ◽  
Antibacterial Properties ◽  
Delivery Systems ◽  
Medical Applications ◽  
Polymer Hybrid ◽  
Current State ◽  
Advanced Biomaterials

Novel bio-inspired materials have gained recently great attention, especially in medical applications. Applying sophisticated design and engineering methods, various polymer-polymer hybrid systems with outstanding performance have been developed in last decades. Hybrid systems composed of bioelastomers and hydrogels are very attractive due to their high biocompatibility and elastic nature for advanced biomaterials used in various medical applications such as drug delivery systems and scaffolds for tissue engineering. Herein, we describe the advances in current state-of-the-art design, properties and applications of polymer-polymer hybrid systems in medical applications. Bio-inspired functionalities, including bioadhesiveness, injectability, antibacterial properties and degradability applicable to advanced drug delivery systems and medical devices will be discussed in a context of future efforts towards development of bioinspired materials.

scholarly journals Mesoporous Silica Particles as Drug Delivery Systems—The State of the Art in Loading Methods and the Recent Progress in Analytical Techniques for Monitoring These Processes

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 950
Author(s):  
Katarzyna Trzeciak ◽  
Agata Chotera-Ouda ◽  
Irena I. Bak-Sypien ◽  
Marek J. Potrzebowski
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery Systems ◽  
Water Solubility ◽  
State Of The Art ◽  
Mesoporous Silica Nanoparticles ◽  
Analytical Techniques ◽  
Delivery Systems ◽  
Advantages And Disadvantages ◽  
Loading Methods

Conventional administration of drugs is limited by poor water solubility, low permeability, and mediocre targeting. Safe and effective delivery of drugs and therapeutic agents remains a challenge, especially for complex therapies, such as cancer treatment, pain management, heart failure medication, among several others. Thus, delivery systems designed to improve the pharmacokinetics of loaded molecules, and allowing controlled release and target specific delivery, have received considerable attention in recent years. The last two decades have seen a growing interest among scientists and the pharmaceutical industry in mesoporous silica nanoparticles (MSNs) as drug delivery systems (DDS). This interest is due to the unique physicochemical properties, including high loading capacity, excellent biocompatibility, and easy functionalization. In this review, we discuss the current state of the art related to the preparation of drug-loaded MSNs and their analysis, focusing on the newest advancements, and highlighting the advantages and disadvantages of different methods. Finally, we provide a concise outlook for the remaining challenges in the field.

Surface receptor‐mediated targeted drug delivery systems for enhanced cancer treatment: A state‐of‐the‐art review

2020 ◽  
Author(s):  
Selvaraj Kunjiappan ◽  
Parasuraman Pavadai ◽  
Sivakumar Vellaichamy ◽  
Sureshbabu Ram Kumar Pandian ◽  
Vigneshwaran Ravishankar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
State Of The Art ◽  
Delivery Systems ◽  
Surface Receptor ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems
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