Final Results of a Prospective Study Comparing the Local Control of Short-Course and Long-Course Radiotherapy for Metastatic Spinal Cord Compression

Author(s):  
Dirk Rades ◽  
Marisa Lange ◽  
Theo Veninga ◽  
Lukas J.A. Stalpers ◽  
Amira Bajrovic ◽  
...  
2010 ◽  
Vol 06 (01) ◽  
pp. 24
Author(s):  
Dirk Rades ◽  
Steven E Schild ◽  
◽  

Radiotherapy (RT) alone is the most frequently applied treatment modality for metastatic spinal cord compression (MSCC). Short-course RT (overall treatment time one week or less) provides a similar functional outcome to longer programmes. Therefore, short-course RT should be seriously considered for many MSCC patients, especially for those with a poor survival prognosis. By contrast, a considerable proportion of MSCC patients live long enough to experience a local recurrence of MSCC in the previously irradiated area of the spinal cord. Long-course RT (30–40Gy in two to four weeks) results in significantly better local control than short-course RT and should therefore be administered to patients with a more favourable survival prognosis. Survival can be estimated with a newly developed scoring system. If re-irradiation is required, a second course of RT can be safely administered in most cases after primary short-course RT. After primary long-course RT, re-irradiation should optimally be performed with high-precision techniques in order to reduce the risk of radiation-related myelopathy.


Medicine ◽  
2015 ◽  
Vol 94 (43) ◽  
pp. e1843 ◽  
Author(s):  
Song Qu ◽  
Hui-Ling Meng ◽  
Zhong-Guo Liang ◽  
Xiao-Dong Zhu ◽  
Ling Li ◽  
...  

1997 ◽  
Vol 38 (5) ◽  
pp. 1037-1044 ◽  
Author(s):  
Ernesto Maranzano ◽  
Paolo Latini ◽  
Elisabetta Perrucci ◽  
Sara Beneventi ◽  
Marco Lupattelli ◽  
...  

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