Analysis of Beam Delivery Times and Dose Rates for the Treatment of Mobile Tumors Using Real Time Image Gated Spot-Scanning Proton Beam Therapy

2018 ◽  
Vol 102 (3) ◽  
pp. S182-S183
Author(s):  
S. Shimizu ◽  
T. Yoshimura ◽  
N. Katoh ◽  
T. Inoue ◽  
T. Hashimoto ◽  
...  
2019 ◽  
Vol 21 (2) ◽  
pp. 38-49 ◽  
Author(s):  
Takaaki Yoshimura ◽  
Shinichi Shimizu ◽  
Takayuki Hashimoto ◽  
Kentaro Nishioka ◽  
Norio Katoh ◽  
...  

2020 ◽  
Vol 21 (12) ◽  
pp. 10-19
Author(s):  
Takaaki Yoshimura ◽  
Shinichi Shimizu ◽  
Takayuki Hashimoto ◽  
Kentaro Nishioka ◽  
Norio Katoh ◽  
...  

2017 ◽  
Vol 58 (4) ◽  
pp. 591-597 ◽  
Author(s):  
Yusuke Fujii ◽  
Taeko Matsuura ◽  
Seishin Takao ◽  
Yuka Matsuzaki ◽  
Takaaki Fujii ◽  
...  

Abstract For proton spot scanning, use of a real-time-image gating technique incorporating an implanted marker and dual fluoroscopy facilitates mitigation of the dose distribution deterioration caused by interplay effects. This study explored the advantages of using a real-time-image gating technique, with a focus on prostate cancer. Two patient-positioning methods using fiducial markers were compared: (i) patient positioning only before beam delivery, and (ii) patient positioning both before and during beam delivery using a real-time-gating technique. For each scenario, dose distributions were simulated using the CT images of nine prostate cancer patients. Treatment plans were generated using a single-field proton beam with 3-mm and 6-mm lateral margins. During beam delivery, the prostate was assumed to move by 5 mm in four directions that were perpendicular to the beam direction at one of three separate timings (i.e. after the completion of the first, second and third quartiles of the total delivery of spot irradiation). Using a 3-mm margin and second quartile motion timing, the averaged values for ΔD99, ΔD95, ΔD5 and D5–95 were 5.1%, 3.3%, 3.6% and 9.0%, respectively, for Scenario (i) and 2.1%, 1.5%, 0.5% and 4.1%, respectively, for Scenario (ii). The margin expansion from 3 mm to 6 mm reduced the size of ΔD99, ΔD95, ΔD5 and D5–95 only with Scenario (i). These results indicate that patient positioning during beam delivery is an effective way to obtain better target coverage and uniformity while reducing the target margin when the prostate moves during irradiation.


PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e94971 ◽  
Author(s):  
Shinichi Shimizu ◽  
Naoki Miyamoto ◽  
Taeko Matsuura ◽  
Yusuke Fujii ◽  
Masumi Umezawa ◽  
...  

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