Management of facial erythema of rosacea: What is the role of topical α-adrenergic receptor agonist therapy?

2013 ◽  
Vol 69 (6) ◽  
pp. S44-S56 ◽  
Author(s):  
James Q. Del Rosso
Keyword(s):  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
Agonist Therapy ◽  
Facial Erythema ◽  
Adrenergic Receptor Agonist

Endolymphatic sac is involved in the regulation of hydrostatic pressure of cochlear endolymph

2009 ◽  
Vol 297 (5) ◽  
pp. R1610-R1614 ◽  
Author(s):  
Ryuhei Inamoto ◽  
Takenori Miyashita ◽  
Kosuke Akiyama ◽  
Terushige Mori ◽  
Nozomu Mori
Keyword(s):  
Hydrostatic Pressure ◽  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
Marked Change ◽  
Endocochlear Potential ◽  
Endolymphatic Sac ◽  
Endolymphatic Pressure ◽  
Adrenergic Receptor Agonist ◽  
Current Potential

To clarify the role of the endolymphatic sac (ES) in the regulation of endolymphatic pressure, the effects of isoproterenol, a β-adrenergic receptor agonist, and acetazolamide, a potent carbonic anhydrase inhibitor, both of which decrease ES direct current potential on cochlear hydrostatic pressure, were examined in guinea pigs. When isoproterenol was applied intravenously, hydrostatic pressures of cochlear endolymph and perilymph were significantly increased with no change in endocochlear potential or the hydrostatic pressure of cerebrospinal fluid. Acetazolamide produced no marked change in the hydrostatic pressure of cochlear endolymph. In ears with an obstructed ES, the action of isoproterenol on the hydrostatic pressure of cochlear endolymph and perilymph was suppressed. These results suggest that the ES may regulate the hydrostatic pressure of the endolymphatic system via the action of the agents such as catecholamines on the ES.

β-Adrenergic regulation of Na+ uptake by larval zebrafish Danio rerio in acidic and ion-poor environments

2012 ◽  
Vol 303 (10) ◽  
pp. R1031-R1041 ◽  
Author(s):  
Yusuke Kumai ◽  
Mellissa A. R. Ward ◽  
Steve F. Perry
Keyword(s):  
Danio Rerio ◽  
Adrenergic Receptors ◽  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
Acidic Water ◽  
Adrenergic Systems ◽  
Β Receptor ◽  
Β Adrenergic Receptors ◽  
Adrenergic Receptor Agonist

The potential role of adrenergic systems in regulating Na+ uptake in zebrafish ( Danio rerio) larvae was investigated. Treatment with isoproterenol (a generic β-adrenergic receptor agonist) stimulated Na+ uptake, whereas treatment with phenylephrine (an α1-adrenergic receptor agonist) as well as clonidine (an α2-adrenergic receptor agonist) significantly reduced Na+ uptake, suggesting opposing roles of α- and β-adrenergic receptors in Na+ uptake regulation. The increase in Na+ uptake associated with exposure to acidic water (pH = 4.0) was attenuated in the presence of the nonselective β-receptor antagonist propranolol or the β1-receptor blocker atenolol; the β2-receptor antagonist ICI-118551 was without effect. The stimulation of Na+ uptake associated with ion-poor water (32-fold dilution of Ottawa tapwater) was unaffected by β-receptor blockade. Translational gene knockdown of β-receptors using antisense oligonucleotide morpholinos was used as a second method to assess the role of adrenergic systems in the regulation of Na+ uptake. Whereas β1- or β2B-receptor knockdown led to significant decreases in Na+ uptake during exposure to acidic water, only β2A-receptor morphants failed to increase Na+ uptake in response to ion-poor water. In support of the pharmacology and knockdown experiments that demonstrated an involvement of β-adrenergic systems in the control of Na+ uptake, we showed that the H+-ATPase-rich (HR) cell, a subtype of ionocyte known to be a site of Na+ uptake, is innervated and appears to express β-adrenergic receptors (propranolol binding sites) at 4 days postfertilization. These data indicate an important role of adrenergic systems in regulating Na+ uptake in developing zebrafish.

Role of ventrolateral medulla in sympatholytic effect of 8-OHDPAT in rats

1991 ◽  
Vol 260 (3) ◽  
pp. R600-R609 ◽  
Author(s):  
A. Nosjean ◽  
P. G. Guyenet
Keyword(s):  
Adrenergic Receptors ◽  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
Discharge Rate ◽  
Ventrolateral Medulla ◽  
Adrenergic Antagonists ◽  
Raphe Pallidus ◽  
Adrenergic Receptor Agonist ◽  
Nerve Discharge

In halothane-anesthetized, paralyzed, and artificially ventilated rats, the putative 5-hydroxytryptamine1A receptor agonist 8-OHDPAT (13.1 micrograms/kg iv) produced hypotension (-14.6 +/- 1.3 mmHg, n = 35), reduced lumbar sympathetic nerve discharge (SND, -17.8%, n = 35), and slowed the discharge rate of sympathoexcitatory neurons recorded in the rostroventrolateral medulla (RVLM, -17.6%, n = 20). The gain of the baroreflex was unaffected by the drug, but SND and RVLM unit discharges were silenced at significantly reduced levels of mean arterial pressure (MAP; 153 vs. 171 mmHg for SND, 155 vs. 172 mmHg for RVLM cells). Subsequent intravenous administration of the alpha 2-adrenergic receptor agonist clonidine (5.3 micrograms/kg) produced an additional decrease in MAP (-21.2 +/- 1.9 mmHg, n = 24) and SND (-24%, n = 24), Bilateral microinjections of 8-OHDPAT into the RVLM (1 nmol/side, n = 9) or into the raphe pallidus-obscurus (2 injections of 1 nmol each, n = 7) also produced hypotension (-22.9 +/- 3.2 and -14.4 +/- 2.8 mmHg, respectively) and sympathoinhibition (-39.1 and -24.6%, respectively). Bilateral microinjection into RVLM of the alpha 2-adrenergic antagonists idazoxan (16 nmol/side, n = 6) or rauwolscine (2 nmol/side, n = 6) attenuated the sympatholytic effect of both 8-OHDPAT (13.1 micrograms/kg, iv) and clonidine (5.3 micrograms/kg iv). These results suggest that 8-OHDPAT may exert a portion of its central sympatholytic effect by activating alpha 2-adrenergic receptors in the rostroventral medulla.

scholarly journals Repeated β2-Adrenergic Receptor Agonist Therapy Attenuates the Response to Rescue Bronchodilation in a Hyperoxic Newborn Mouse Model

Neonatology ◽  
2014 ◽  
Vol 106 (2) ◽  
pp. 126-132 ◽  
Author(s):  
Thomas Raffay ◽  
Prabha Kc ◽  
James Reynolds ◽  
Juliann Di Fiore ◽  
Peter MacFarlane ◽  
...  
Keyword(s):  
Mouse Model ◽  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
Newborn Mouse ◽  
Agonist Therapy ◽  
Β2 Adrenergic Receptor ◽  
Adrenergic Receptor Agonist

Physiological Responses to Daily Use of Beta-Three Adrenergic Receptor Agonist, Mirabegron

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1146-P
Author(s):  
ALANA O'MARA ◽  
AARON CYPESS ◽  
CHERYL CERO ◽  
JAMES W. JOHNSON ◽  
JOYCE D. LINDERMAN ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
Physiological Responses ◽  
Adrenergic Receptor Agonist

scholarly journals Long-acting β2-adrenergic receptor agonist in pediatric asthma

2004 ◽  
Vol 53 (2) ◽  
pp. 69-75 ◽  
Author(s):  
Shigemi Yoshihara ◽  
Yumi Yamada ◽  
Toshio Abe ◽  
Osamu Arisaka
Keyword(s):  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
Pediatric Asthma ◽  
Β2 Adrenergic Receptor ◽  
Long Acting ◽  
Adrenergic Receptor Agonist
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