Low HDL Cholesterol Situations is Characterised by Elevated Oxidative Stress

Background: Telomerase Activator 65 (TA-65), a compound extracted from Astragalus membranaceus has been used in Chinese traditional medicine for extending lifespan. Scarce information exists on the effects of TA-65 on parameters of metabolic syndrome (MetS). Methods: We recruited 40 patients with MetS to determine the effects of TA-65 on dyslipidemias, hypertension, and oxidative stress in this at-risk population. The study was a double-blind, randomized crossover design in which patients were allocated to consume either 16 mg daily of a TA-65 supplement or a placebo for 12 weeks. Following a 3-week washout, participants were allocated to the alternate treatment for an additional 12 weeks. Anthropometric and biological markers were measured at the end of each treatment. Plasma lipids, glucose, CReactive Protein (CRP), liver enzymes, and glycosylated hemoglobin were measured using a Cobas c-111. Inflammatory cytokines were measured by Luminex technology and markers of oxidative stress by the use of spectroscopy. Results: Compared to the placebo period, HDL cholesterol (HDL-C) was higher while body mass index, waist circumference, and the LDL/HDL ratio were lower (p < 0.05) during TA-65 treatment. In addition, plasma tumor necrosis factor-α (TNF-α) was lower during the TA-65 period (p< 0.05). Positive correlations were observed in changes between the placebo and the TA-65 periods in HDL-C and CRP (r = -0.511, p < 0.01), alanine aminotransferase (r = -0.61, p < 0.001) and TNF-α (r = -0.550, p < 0.001) suggesting that the favorable changes observed in HDL were associated with decreases in inflammation. Conclusion: TA-65 improved key markers of cardiovascular disease risk, which were also associated with reductions in inflammation.

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Association between the Mediterranean lifestyle, metabolic syndrome and mortality: a whole-country cohort in Spain

Cardiovascular Diabetology ◽

10.1186/s12933-020-01195-1 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Mercedes Sotos-Prieto ◽

Rosario Ortolá ◽

Miguel Ruiz-Canela ◽

Esther Garcia-Esquinas ◽

David Martínez-Gómez ◽

...

Keyword(s):

Metabolic Syndrome ◽

Cardiovascular Mortality ◽

Cardiovascular Health ◽

Total Mortality ◽

Hdl Cholesterol ◽

Cardiometabolic Health ◽

The Metabolic Syndrome ◽

Mediterranean Countries ◽

Low Hdl ◽

The Mediterranean

Abstract Background Evidence is limited about the joint health effects of the Mediterranean lifestyle on cardiometabolic health and mortality. The aim of this study was to evaluate the association of the Mediterranean lifestyle with the frequency of the metabolic syndrome (MS) and the risk of all-cause and cardiovascular mortality in Spain. Methods Data were taken from ENRICA study, a prospective cohort of 11,090 individuals aged 18+ years, representative of the population of Spain, who were free of cardiovascular disease (CVD) and diabetes at 2008–2010 and were followed-up to 2017. The Mediterranean lifestyle was assessed at baseline with the 27-item MEDLIFE index (with higher score representing better adherence). Results Compared to participants in the lowest quartile of MEDLIFE, those in the highest quartile had a multivariable-adjusted odds ratio 0.73 (95% confidence interval (CI) 0.5, 0.93) for MS, 0.63. (0.51, 0.80) for abdominal obesity, and 0.76 (0.63, 0.90) for low HDL-cholesterol. Similarly, a higher MELDIFE score was associated with lower HOMA-IR and highly-sensitivity C-reactive protein (P-trend < 0.001). During a mean follow-up of 8.7 years, 330 total deaths (74 CVD deaths) were ascertained. When comparing those in highest vs. lowest quartile of MEDLIFE, the multivariable-adjusted hazard ratio (95% CI) was 0.58 (0.37, 0.90) for total mortality and 0.33 (0.11, 1.02) for cardiovascular mortality. Conclusions The Mediterranean lifestyle was associated with lower frequency of MS and reduced all-cause mortality in Spain. Future studies should determine if this also applies to other Mediterranean countries, and also improve cardiovascular health outside the Mediterranean basin.

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High prevalence of low HDL cholesterol concentrations and mixed hyperlipidemia in a Mexican nationwide survey

The Journal of Lipid Research ◽

10.1016/s0022-2275(20)31581-9 ◽

2001 ◽

Vol 42 (8) ◽

pp. 1298-1307 ◽

Cited By ~ 8

Author(s):

Carlos A. Aguilar-Salinas ◽

Gustavo Olaiz ◽

Victoria Valles ◽

Juan Manuel Ríos Torres ◽

Francisco J. Gómez Pérez ◽

...

Keyword(s):

Hdl Cholesterol ◽

Nationwide Survey ◽

High Prevalence ◽

Low Hdl ◽

Mixed Hyperlipidemia

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Heritability of the metabolic syndrome and its components in the Tehran Lipid and Glucose Study (TLGS)

Genetics Research ◽

10.1017/s001667231200050x ◽

2012 ◽

Vol 94 (6) ◽

pp. 331-337 ◽

Cited By ~ 30

Author(s):

MARYAM ZARKESH ◽

MARYAM SADAT DANESHPOUR ◽

BITA FAAM ◽

MOHAMMAD SADEGH FALLAH ◽

NIMA HOSSEINZADEH ◽

...

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Hdl Cholesterol ◽

Age And Gender ◽

The Metabolic Syndrome ◽

Biological Parents ◽

Heritability Estimation ◽

Low Hdl ◽

And Gender ◽

Continuous Traits

SummaryGrowing evidence suggests that metabolic syndrome (MetS) has both genetic and environmental bases. We estimated the heritability of the MetS and its components in the families from the Tehran Lipid and Glucose Study (TLGS). We investigated 904 nuclear families in TLGS with two biological parents and at least one offspring (1565 parents and 2448 children), aged 3–90 years, for whom MetS information was available and had at least two members of family with MetS. Variance component methods were used to estimate age and sex adjusted heritability of metabolic syndrome score (MSS) and MetS components using SOLAR software. The heritability of waist circumference (WC), HDL-cholesterol (HDL-C), triglycerides (TGs), fasting blood sugar (FBS), systolic blood pressure (SBP) and diastolic blood pressure (DBP) as continuous traits after adjusting for age and gender were 27, 46, 36, 29, 25, 26 and 15%, respectively, and MSS had a heritability of 15%. When MetS components were analysed as discrete traits, the estimates of age and gender adjusted heritability for MetS, abdominal obesity, low HDL-C, high TG, high FBS and high blood pressure (BP) were 22, 40, 34, 38 and 23%, respectively (P < 0·05). Three factors were extracted from the six continuous traits of the MetS including factor I (BP), factor II (lipids) and factor III (obesity and FBS). Heritability estimation for these three factors were 7, 13 (P < 0·05) and 2%, respectively. The highest heritability was for HDL-C and TG. The results strongly encourage efforts to identify the underlying susceptibility genes.

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THE EFFECTS OF NICOTINIC ACID ON BLOOD LIPIDS IN PATIENTS WITH LOW HDL-CHOLESTEROL AND NORMAL TOTAL CHOLESTEROL LEVELS

Journal of Cardiopulmonary Rehabilitation ◽

10.1097/00008483-198910200-00047 ◽

1989 ◽

Vol 9 (10) ◽

pp. 414 ◽

Cited By ~ 2

Author(s):

R. W. Squire ◽

G. T. Gau ◽

B. A. Kottke ◽

T. D. Miller ◽

T. G. Allison ◽

...

Keyword(s):

Nicotinic Acid ◽

Total Cholesterol ◽

Blood Lipids ◽

Hdl Cholesterol ◽

Cholesterol Levels ◽

Low Hdl

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A Novel Mutant, ApoA-I Nichinan (Glu235→0), Is Associated With Low HDL Cholesterol Levels and Decreased Cholesterol Efflux From Cells

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/01.atv.19.6.1447 ◽

1999 ◽

Vol 19 (6) ◽

pp. 1447-1455 ◽

Cited By ~ 25

Author(s):

Hua Han ◽

Jun Sasaki ◽

Akira Matsunaga ◽

Hideki Hakamata ◽

Wei Huang ◽

...

Keyword(s):

Cholesterol Efflux ◽

Hdl Cholesterol ◽

Cholesterol Levels ◽

Low Hdl

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Reduced risk of dyslipidaemia with oolong tea consumption: a population-based study in southern China

British Journal Of Nutrition ◽

10.1017/s0007114513003644 ◽

2013 ◽

Vol 111 (8) ◽

pp. 1421-1429 ◽

Cited By ~ 9

Author(s):

Deqing Yi ◽

Xuerui Tan ◽

Zhiguo Zhao ◽

Yingmu Cai ◽

Yiming Li ◽

...

Keyword(s):

Southern China ◽

Experimental Studies ◽

Hdl Cholesterol ◽

Black Tea ◽

Population Based ◽

Tea Consumption ◽

Oolong Tea ◽

Cholesterol Levels ◽

Low Hdl ◽

Biochemical Indices

Experimental studies have suggested that tea consumption could lower the risk of dyslipidaemia. However, epidemiological evidence is limited, especially in southern China, where oolong tea is the most widely consumed beverage. We conducted a population-based case–control study to evaluate the association between consumption of tea, especially oolong tea, and risk of dyslipidaemia in Shantou, southern China, from 2010 to 2011. Information on tea consumption, lifestyle characteristics and food consumption frequency of 1651 patients with newly diagnosed dyslipidaemia and 1390 controls was obtained using a semi-quantitative questionnaire. Anthropometric variables and serum biochemical indices were determined. Drinking more than 600 ml (2 paos) of green, oolong or black tea daily was found to be associated with the lowest odds of dyslipidaemia risk (P< 0·001) when compared with non-consumption, but only oolong tea consumption was found to be associated with low HDL-cholesterol levels. A dose–response relationship between duration of tea consumption and risk of dyslipidaemia (OR 0·10, 95 % CI 0·06, 0·16), as well as that between amount of dried tea leaves brewed and risk of dyslipidaemia (OR 0·34, 95 % CI 0·24, 0·48), was found. Moreover, consumption of oolong tea for the longest duration was found to be associated with 3·22, 11·99 and 6·69 % lower blood total cholesterol, TAG and LDL-cholesterol levels, respectively. In conclusion, the present study indicates that long-term oolong tea consumption may be associated with a lower risk of dyslipidaemia in the population of Shantou in southern China.

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