The impact of general intellectual ability and white matter volume on the functional outcome of patients with Bipolar Disorder and their relatives

2011 ◽  
Vol 130 (3) ◽  
pp. 413-420 ◽  
Author(s):  
Irene Forcada ◽  
Efstathios Papachristou ◽  
Maria Mur ◽  
Tessa Christodoulou ◽  
Jigar Jogia ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
White Matter ◽  
Functional Outcome ◽  
Intellectual Ability ◽  
White Matter Volume ◽  
Matter Volume ◽  
General Intellectual Ability ◽  
The Impact

26.1 GRAY AND WHITE MATTER VOLUME ALTERATIONS IN YOUTH OFFSPRING OF PARENTS WITH BIPOLAR DISORDER

2016 ◽  
Vol 55 (10) ◽  
pp. S298
Author(s):  
Melissa P. DelBello ◽  
Fabiano Nery ◽  
Wade Weber ◽  
Thomas J. Blom ◽  
Jeffrey A. Welge ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
White Matter ◽  
White Matter Volume ◽  
Matter Volume

scholarly journals Meta-analysis of regional white matter volume in bipolar disorder with replication in an independent sample using coordinates, T-maps, and individual MRI data

2018 ◽  
Vol 84 ◽  
pp. 162-170 ◽  
Author(s):  
Stefania Pezzoli ◽  
Louise Emsell ◽  
Sarah W. Yip ◽  
Danai Dima ◽  
Panteleimon Giannakopoulos ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
White Matter ◽  
Meta Analysis ◽  
White Matter Volume ◽  
Matter Volume

scholarly journals White matter volume is decreased in bipolar disorder at early and late stages

2018 ◽  
Vol 40 (4) ◽  
pp. 277-284 ◽  
Author(s):  
Juliana A. Duarte ◽  
Raffael Massuda ◽  
Pedro D. Goi ◽  
Mireia Vianna-Sulzbach ◽  
Rafael Colombo ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
White Matter ◽  
Late Stage ◽  
Early Stage ◽  
Type I ◽  
White Matter Volume ◽  
Matter Volume ◽  
Early Biomarkers ◽  
Late Stages ◽  
Mood Condition

Abstract Introduction: Bipolar disorder (BD) is a debilitating mood condition that affects approximately 1.3% of people worldwide, although some studies report up to 3.9% lifetime prevalence and 4-6% in adults when broad diagnostic criteria are applied. Objective: To compare differences in total white matter (WM), corpus callosum (CC) and total gray matter (GM) volumes in patients with type I BD at early and late stages compared with controls. Methods: Fifty-five subjects were enrolled in this study protocol. The double case-control design included 14 patients with BD at early stage; 15 patients at late stage; and their respective matched controls (14 and 12 subjects). Results: CC and total WM volumes were significantly smaller in patients with BD at early and late stages vs. controls. There was no difference for total GM volume in the early stage group, but in patients at late stage total GM volume was significantly smaller than in controls. The total GM volume reduction in patients at late stage is in agreement with the neuroprogression theory of BD. The reduction of WM volumes in total WM and in the CC at early and late stages supports the possibility that an early demyelination process could occur underlying the clinical manifestation of BD. Conclusion: Our findings may direct to the investigation of WM abnormalities in populations at high risk to develop BD, perhaps as early biomarkers before the overt syndrome.

scholarly journals Differential Impact of Cognitive Impairment in MCI Patients: A Case-Based Report

2020 ◽  
Vol 12 (2) ◽  
pp. 222-231
Author(s):  
Valentina Pergher ◽  
Birgitte Schoenmakers ◽  
Philippe Demaerel ◽  
Jos Tournoy ◽  
Marc M. Van Hulle
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
Test Performance ◽  
Intermediate Stage ◽  
Cognitive Test ◽  
White Matter Volume ◽  
Matter Volume ◽  
Mri Scans ◽  
Cognitive Test Performance ◽  
The Impact

Mild cognitive impairment (MCI) traditionally refers to an intermediate stage between healthy individuals and early Alzheimer disease. Evidence shows grey and white matter volume changes and decrease in several executive functions, albeit the relation between cognitive performance and brain volume remains unclear. Here, we discuss 3 individual cases of MCI by investigating their MRI scans and cognitive test performance. We also recruited age-matched healthy older adults serving as gold standard for both grey and white matter volume and cognitive test outcomes. Our results show the impact of cognitive impairment on cognitive test performance and grey and white matter volumes, and the role played by cognitive and brain reserve on mitigating cognitive decline. Furthermore, we add evidence to previous studies by showing an increase in white matter volume compared to healthy controls, in all 3 patients. This pattern of increased white matter volume might help us to better understand the pathological mechanisms underlying MCI which in turn could contribute to future investigations.

scholarly journals Preliminary Evidence for a Relationship between Elevated Plasma TNFα and Smaller Subcortical White Matter Volume in HCV Infection Irrespective of HIV or AUD Comorbidity

2021 ◽  
Vol 22 (9) ◽  
pp. 4953
Author(s):  
Natalie M. Zahr ◽  
Kilian M. Pohl ◽  
Allison J. Kwong ◽  
Edith V. Sullivan ◽  
Adolf Pfefferbaum
Keyword(s):  
White Matter ◽  
Proinflammatory Cytokines ◽  
Soluble Protein ◽  
Subcortical White Matter ◽  
Control Group ◽  
White Matter Volume ◽  
Brain Volumes ◽  
Protein Levels ◽  
Matter Volume ◽  
Patient Groups

Classical inflammation in response to bacterial, parasitic, or viral infections such as HIV includes local recruitment of neutrophils and macrophages and the production of proinflammatory cytokines and chemokines. Proposed biomarkers of organ integrity in Alcohol Use Disorders (AUD) include elevations in peripheral plasma levels of proinflammatory proteins. In testing this proposal, previous work included a group of human immunodeficiency virus (HIV)-infected individuals as positive controls and identified elevations in the soluble proteins TNFα and IP10; these cytokines were only elevated in AUD individuals seropositive for hepatitis C infection (HCV). The current observational, cross-sectional study evaluated whether higher levels of these proinflammatory cytokines would be associated with compromised brain integrity. Soluble protein levels were quantified in 86 healthy controls, 132 individuals with AUD, 54 individuals seropositive for HIV, and 49 individuals with AUD and HIV. Among the patient groups, HCV was present in 24 of the individuals with AUD, 13 individuals with HIV, and 20 of the individuals in the comorbid AUD and HIV group. Soluble protein levels were correlated to regional brain volumes as quantified with structural magnetic resonance imaging (MRI). In addition to higher levels of TNFα and IP10 in the 2 HIV groups and the HCV-seropositive AUD group, this study identified lower levels of IL1β in the 3 patient groups relative to the control group. Only TNFα, however, showed a relationship with brain integrity: in HCV or HIV infection, higher peripheral levels of TNFα correlated with smaller subcortical white matter volume. These preliminary results highlight the privileged status of TNFα on brain integrity in the context of infection.

Gray and white matter volume abnormalities in monozygotic and same-sex dizygotic twins discordant for schizophrenia

2003 ◽  
Vol 60 (1) ◽  
pp. 198
Author(s):  
H. Hulshoff Pol ◽  
R. Brans ◽  
N. Haren ◽  
M. Langen ◽  
H.G. Schnack ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Volume ◽  
Same Sex ◽  
Matter Volume ◽  
Dizygotic Twins
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