Further evidence of a dissociation between decision-making under ambiguity and decision-making under risk in obsessive–compulsive disorder

2015 ◽  
Vol 176 ◽  
pp. 118-124 ◽  
Author(s):  
Hae Won Kim ◽  
Jee In Kang ◽  
Kee Namkoong ◽  
Kyungun Jhung ◽  
Ra Yeon Ha ◽  
...  
Keyword(s):  
Decision Making ◽  
Obsessive Compulsive Disorder ◽  
Decision Making Under Risk ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals Decision-making under uncertainty in obsessive–compulsive disorder

2015 ◽  
Vol 69 ◽  
pp. 166-173 ◽  
Author(s):  
Helen Pushkarskaya ◽  
David Tolin ◽  
Lital Ruderman ◽  
Ariel Kirshenbaum ◽  
J. MacLaren Kelly ◽  
...  
Keyword(s):  
Decision Making ◽  
Obsessive Compulsive Disorder ◽  
Decision Making Under Uncertainty ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

Inhibition of Habitual Decision-Making Circuitry in Obsessive-Compulsive Disorder

2021 ◽  
Vol 89 (9) ◽  
pp. S359
Author(s):  
Darsol Seok ◽  
Reza Tadayon-Nejad ◽  
Wan-wa Wong ◽  
Joseph O'Neill ◽  
Jamie Feusner
Keyword(s):  
Decision Making ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals Increased fronto-striatal reward prediction errors moderate decision making in obsessive–compulsive disorder

2017 ◽  
Vol 47 (7) ◽  
pp. 1246-1258 ◽  
Author(s):  
T. U. Hauser ◽  
R. Iannaccone ◽  
R. J. Dolan ◽  
J. Ball ◽  
J. Hättenschwiler ◽  
...  
Keyword(s):  
Decision Making ◽  
Obsessive Compulsive Disorder ◽  
Late Onset ◽  
Anterior Cingulate ◽  
Prediction Errors ◽  
Learning Mechanisms ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Reward Prediction ◽  
Reinforcement Learning Models

BackgroundObsessive–compulsive disorder (OCD) has been linked to functional abnormalities in fronto-striatal networks as well as impairments in decision making and learning. Little is known about the neurocognitive mechanisms causing these decision-making and learning deficits in OCD, and how they relate to dysfunction in fronto-striatal networks.MethodWe investigated neural mechanisms of decision making in OCD patients, including early and late onset of disorder, in terms of reward prediction errors (RPEs) using functional magnetic resonance imaging. RPEs index a mismatch between expected and received outcomes, encoded by the dopaminergic system, and are known to drive learning and decision making in humans and animals. We used reinforcement learning models and RPE signals to infer the learning mechanisms and to compare behavioural parameters and neural RPE responses of the OCD patients with those of healthy matched controls.ResultsPatients with OCD showed significantly increased RPE responses in the anterior cingulate cortex (ACC) and the putamen compared with controls. OCD patients also had a significantly lower perseveration parameter than controls.ConclusionsEnhanced RPE signals in the ACC and putamen extend previous findings of fronto-striatal deficits in OCD. These abnormally strong RPEs suggest a hyper-responsive learning network in patients with OCD, which might explain their indecisiveness and intolerance of uncertainty.

scholarly journals Think twice: Impulsivity and decision making in obsessive–compulsive disorder

2015 ◽  
Vol 4 (4) ◽  
pp. 263-272 ◽  
Author(s):  
Giacomo Grassi ◽  
Stefano Pallanti ◽  
Lorenzo Righi ◽  
Martijn Figee ◽  
Mariska Mantione ◽  
...  
Keyword(s):  
Decision Making ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Compulsive Disorder
Sign in / Sign up

Export Citation Format

Share Document