Re-experiencing phenomena following a disaster: The long-term predictive role of intrusion symptoms in the development of post-trauma depression and anxiety

2016 ◽  
Vol 190 ◽  
pp. 278-281 ◽  
Author(s):  
Ellie Lawrence-Wood ◽  
Miranda Van Hooff ◽  
Jenelle Baur ◽  
Alexander C. McFarlane
Keyword(s):  
Depression And Anxiety ◽  
Predictive Role

KIDNEY TRANSPLANTATION FROM MARGINAL DONORS. PREDICTIVE ROLE OF BIOPSY SCORE FOR LONG TERM GRAFT SURVIVAL AND TRANSPLANT OUTCOME

2008 ◽  
Vol 86 (Supplement) ◽  
pp. 582
Author(s):  
S Cristino ◽  
M P. Scolari ◽  
G La Manna ◽  
A Faenza ◽  
G Mosconi ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Graft Survival ◽  
Transplant Outcome ◽  
Predictive Role ◽  
Marginal Donors ◽  
Biopsy Score

scholarly journals The Developmental Role of Serotonin: A Comparison of Short- and Long-term Blockade of the Serotonin Transporter on Behavioural Outcomes in Adulthood

2021 ◽  
Author(s):  
◽  
Amy O'Connell
Keyword(s):  
Animal Model ◽  
Serotonin Transporter ◽  
Anxiety And Depression ◽  
Depression And Anxiety ◽  
Critical Periods ◽  
Significant Group ◽  
Fluoxetine Treatment ◽  
Short And Long Term

<p>Serotonin is an important neurotransmitter that regulates a range of processes within the brain and is implicated in several psychiatric disorders. In addition, serotonin acts as a developmental signal during critical periods of prenatal development, influencing processes such as neuronal proliferation, migration, and synaptogenesis (Gaspar et al., 2003). The serotonin transporter (5- HTT) plays a key role in regulating extracellular serotonin levels and is the main target of selective-serotonin reuptake inhibitors (SSRIs), a class of drugs that have anti-anxiety and anti- depressive activity. SSRIs cause an acute increase in extracellular serotonin and are commonly prescribed as a treatment for depression and anxiety during pregnancy (Tran & Robb, 2015). Given that these drugs alter serotonin transmission and can pass to the developing fetus via the placenta, it is vital that the outcomes of prenatal SSRI exposure are investigated. In humans, a genetic variant of the gene that codes for the 5-HTT (SLC6A4) has been linked to increased risk for developing depression and anxiety (Caspi et al., 2003). The functional consequences of this genetic polymorphism are life-long alterations in 5-HTT activity, resulting in increased extracellular levels of serotonin (Nakamura et al., 2000). Given prenatal SSRI exposure results in a time-locked blockade of 5-HTT during critical periods of development, it follows that alterations in serotonin during development might similarly result in enhanced risk for depression and anxiety later in life. Outcomes in children prenatally exposed to SSRIs are difficult to study due to confounds of pre- existing maternal depression. Therefore, the current thesis presents two experiments that aimed to further investigate the role of altered extracellular serotonin levels during development in an animal model. Experiment one aimed to develop a method of voluntary oral administration of the SSRI fluoxetine to pregnant rat dams. This method was then applied in experiment two to create a time-locked blockade of 5-HTT during critical periods of development in an animal model of life-long 5-HTT blockade. The aim of experiment two was to directly assess the contribution of short- and long-term 5-HTT blockade on anxiety and depression phenotypes in adult male offspring. In addition, maternal behaviour was assessed to determine whether fluoxetine treatment had an influence on mother-pup interactions that could confound results. To test for anxiety and depression phenotypes, the novel affective disorder test (ADT) was used to assess anxiety behaviour and the deficits in anticipatory pleasure indicative of anhedonia. In the current study, fluoxetine treatment did not have an effect on litter outcomes or mother-pup interactions. Crucially, no significant group differences were found indicating that neither short- nor long- term blockade of 5-HTT resulted in increased anxiety- or depressive-like behaviours in the current experiment. However, limitations with methodological design limit the translatability of these results to the broader literature, and validation of the ADT is required before these results can be generalised beyond this thesis.</p>

scholarly journals Corona Anxiety in Nurses: The Predictive Role of Perceived Social Support and Sense of Coherence

2020 ◽  
Vol 26 (3 Special Issue on COVID-19) ◽  
pp. 320-331
Author(s):  
Sanaz Eyni ◽  
◽  
Matineh Ebadi ◽  
Zohreh Hashemi ◽  
◽  
...  
Keyword(s):  
Social Support ◽  
Sense Of Coherence ◽  
Perceived Social Support ◽  
Pearson Correlation ◽  
Depression And Anxiety ◽  
Statistical Population ◽  
Pearson Correlation Test ◽  
Predictive Role ◽  
Educating Nurses

Objectives: Healthcare workers involved in the fight against corona are at high risk for depression and anxiety; therefore, this study aimed to predict Corona anxiety in nurses based on perceived social support and a sense of coherence. Methods: The research method was descriptive and correlational. The present study’s statistical population consisted of all nurses working in hospitals and clinics in Rasht, employed in 2020, and 200 people participated in the survey online and through virtual networks. Data collection tools included the Corona anxiety Scale, Multidimensional Scale of Perceived Social Support, and Sense of Coherence Inventory-(SOC)13 Scale. Data were analyzed using the Pearson correlation test and simultaneous regression analysis using SPSS V. 23 software. Results: Corona anxiety in nurses had a negative and significant relationship with perceived social support (β=-0.581; P<0.03) and sense of coherence(β=-0.672; P<0.001). Perceived social support and a sense of coherence of 42% of variance predicted Corona anxiety scores in nurses (P<0.01). Conclusion: Therefore, perceived social support and a sense of coherence play an essential role in nurses’ Corona anxiety. Therefore, educating nurses to increase the understanding of cohesion to empower and implement understandable support programs is recommended.

scholarly journals The Developmental Role of Serotonin: A Comparison of Short- and Long-term Blockade of the Serotonin Transporter on Behavioural Outcomes in Adulthood

2021 ◽  
Author(s):  
◽  
Amy O'Connell
Keyword(s):  
Animal Model ◽  
Serotonin Transporter ◽  
Anxiety And Depression ◽  
Depression And Anxiety ◽  
Critical Periods ◽  
Significant Group ◽  
Fluoxetine Treatment ◽  
Short And Long Term

<p>Serotonin is an important neurotransmitter that regulates a range of processes within the brain and is implicated in several psychiatric disorders. In addition, serotonin acts as a developmental signal during critical periods of prenatal development, influencing processes such as neuronal proliferation, migration, and synaptogenesis (Gaspar et al., 2003). The serotonin transporter (5- HTT) plays a key role in regulating extracellular serotonin levels and is the main target of selective-serotonin reuptake inhibitors (SSRIs), a class of drugs that have anti-anxiety and anti- depressive activity. SSRIs cause an acute increase in extracellular serotonin and are commonly prescribed as a treatment for depression and anxiety during pregnancy (Tran & Robb, 2015). Given that these drugs alter serotonin transmission and can pass to the developing fetus via the placenta, it is vital that the outcomes of prenatal SSRI exposure are investigated. In humans, a genetic variant of the gene that codes for the 5-HTT (SLC6A4) has been linked to increased risk for developing depression and anxiety (Caspi et al., 2003). The functional consequences of this genetic polymorphism are life-long alterations in 5-HTT activity, resulting in increased extracellular levels of serotonin (Nakamura et al., 2000). Given prenatal SSRI exposure results in a time-locked blockade of 5-HTT during critical periods of development, it follows that alterations in serotonin during development might similarly result in enhanced risk for depression and anxiety later in life. Outcomes in children prenatally exposed to SSRIs are difficult to study due to confounds of pre- existing maternal depression. Therefore, the current thesis presents two experiments that aimed to further investigate the role of altered extracellular serotonin levels during development in an animal model. Experiment one aimed to develop a method of voluntary oral administration of the SSRI fluoxetine to pregnant rat dams. This method was then applied in experiment two to create a time-locked blockade of 5-HTT during critical periods of development in an animal model of life-long 5-HTT blockade. The aim of experiment two was to directly assess the contribution of short- and long-term 5-HTT blockade on anxiety and depression phenotypes in adult male offspring. In addition, maternal behaviour was assessed to determine whether fluoxetine treatment had an influence on mother-pup interactions that could confound results. To test for anxiety and depression phenotypes, the novel affective disorder test (ADT) was used to assess anxiety behaviour and the deficits in anticipatory pleasure indicative of anhedonia. In the current study, fluoxetine treatment did not have an effect on litter outcomes or mother-pup interactions. Crucially, no significant group differences were found indicating that neither short- nor long- term blockade of 5-HTT resulted in increased anxiety- or depressive-like behaviours in the current experiment. However, limitations with methodological design limit the translatability of these results to the broader literature, and validation of the ADT is required before these results can be generalised beyond this thesis.</p>

Predictive role of anti-gp210 and anticentromere antibodies in long-term outcome of primary biliary cirrhosis

2007 ◽  
Vol 37 (s3) ◽  
pp. S412-S419 ◽  
Author(s):  
Minoru Nakamura ◽  
Atsumasa Komori ◽  
Masahiro Ito ◽  
Hisayoshi Kondo ◽  
Yoshihiro Aiba ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Biliary Cirrhosis ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Predictive Role ◽  
Anticentromere Antibodies

scholarly journals The Predictive Role of ADRA2A rs1800544 and HTR3B rs3758987 Polymorphisms in Motion Sickness Susceptibility

2021 ◽  
Vol 18 (24) ◽  
pp. 13163
Author(s):  
Xinchen Zhang ◽  
Yeqing Sun
Keyword(s):  
Central Nervous System ◽  
Motion Sickness ◽  
Logistic Regression Model ◽  
System Response ◽  
Blood Samples ◽  
Time Points ◽  
Pcr Rflp ◽  
Predictive Role

Motion sickness is a common central nervous system response, the primary sign of which is vomiting. Its susceptibility varies between individuals. To find predictive factors, we investigated the association of ADRA2A rs1800544 and HTR3B rs3758987 with motion sickness susceptibility and examined their mRNA changes during actual voyages. A total of 315 healthy college students were enrolled for SNP genotyping by the PCR-RFLP method. Blood samples were collected from another 42 subjects during two separate voyages to detect their mRNA expression changes at three time points. The frequency of the rs1800544 GG genotype in the susceptibility group was significantly higher (52.26%), and allele G increased the risk of motion sickness (OR = 1.585, 95% CI = 1.136–2.208). In the logistic regression model, the rs3758987 CC+TC genotype and rs1800544 GG genotype increased the risk of motion sickness-induced vomiting (OR = 2.105, 95% CI = 1.112–3.984; OR = 1.992, 95% CI = 1.114–3.571). The ADRA2A mRNA baseline was lower in the GG carriers and the HTR3B mRNA baseline was lower in the TC/CC carriers before sailing, then increased significantly within 24 h and then decreased after a long-term voyage. People carrying the rs1800544 GG genotype seem more susceptible to motion sickness. In combination with the incidence of vomiting during the actual-voyage experiments, our results indicate the involvement of rs1800544 and rs3758987 in motion sickness-induced vomiting.

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