IC-P-010: Diagnostic utility of platelet amyloid precursor protein ratio, red blood cells and plasma beta amyloid (Aβ 1-42) levels in late-onset Alzheimer's disease

2009 ◽  
Vol 5 (4S_Part_1) ◽  
pp. P9-P10
Author(s):  
Ben Ashok ◽  
B'joe Baben ◽  
Vasudevan Devanathan ◽  
Senthil Kumar ◽  
Jeyakumar Rajadhas
Keyword(s):  
Alzheimer’S Disease ◽  
Amyloid Precursor Protein ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Late Onset ◽  
Beta Amyloid ◽  
Precursor Protein ◽  
Diagnostic Utility ◽  
Protein Ratio ◽  
Amyloid Aβ

Exploring the Role of Aggregated Proteomes in the Pathogenesis of Alzheimer’s Disease

2020 ◽  
Vol 21 (12) ◽  
pp. 1164-1173
Author(s):  
Siju Ellickal Narayanan ◽  
Nikhila Sekhar ◽  
Rajalakshmi Ganesan Rajamma ◽  
Akash Marathakam ◽  
Abdullah Al Mamun ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Precursor Protein ◽  
Early Onset ◽  
Late Onset ◽  
Precursor Protein ◽  
Brain Disorder ◽  
Amyloid Aβ ◽  
T Tau

: Alzheimer’s disease (AD) is a progressive brain disorder and one of the most common causes of dementia and death. AD can be of two types; early-onset and late-onset, where late-onset AD occurs sporadically while early-onset AD results from a mutation in any of the three genes that include amyloid precursor protein (APP), presenilin 1 (PSEN 1) and presenilin 2 (PSEN 2). Biologically, AD is defined by the presence of the distinct neuropathological profile that consists of the extracellular β-amyloid (Aβ) deposition in the form of diffuse neuritic plaques, intraneuronal neurofibrillary tangles (NFTs) and neuropil threads; in dystrophic neuritis, consisting of aggregated hyperphosphorylated tau protein. Elevated levels of (Aβ), total tau (t-tau) and phosphorylated tau (ptau) in cerebrospinal fluid (CSF) have become an important biomarker for the identification of this neurodegenerative disease. The aggregation of Aβ peptide derived from amyloid precursor protein initiates a series of events that involve inflammation, tau hyperphosphorylation and its deposition, in addition to synaptic dysfunction and neurodegeneration, ultimately resulting in dementia. The current review focuses on the role of proteomes in the pathogenesis of AD.

Understanding the structural requirements of cyclic sulfone hydroxyethylamines as hBACE1 inhibitors against Aβ plaques in Alzheimer's disease: a predictive QSAR approach

RSC Advances ◽  
2016 ◽  
Vol 6 (34) ◽  
pp. 28171-28186 ◽  
Author(s):  
Pravin Ambure ◽  
Kunal Roy
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Precursor Protein ◽  
Beta Amyloid ◽  
Precursor Protein ◽  
Structural Requirements ◽  
Amyloid Aβ

Beta (β)-site amyloid precursor protein cleaving enzyme 1 (BACE1) is one of the most important targets in Alzheimer's disease (AD), which is responsible for production and accumulation of beta amyloid (Aβ).

scholarly journals Amyloid precursor protein (APP) knock‐in mouse model recapitulates transciptomic signature in human late‐onset Alzheimer’s disease

2020 ◽  
Vol 16 (S2) ◽  
Author(s):  
Marco Antônio De Bastiani ◽  
Eduardo R. Zimmer ◽  
Stefania Forner ◽  
Alessandra Cadete Martini
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Amyloid Precursor Protein ◽  
Late Onset ◽  
Precursor Protein

scholarly journals Beta-Amyloid Precursor Protein (βAPP) Processing in Alzheimer’s Disease (AD) and Age-Related Macular Degeneration (AMD)

2014 ◽  
Vol 52 (1) ◽  
pp. 533-544 ◽  
Author(s):  
Yuhai Zhao ◽  
Surjyadipta Bhattacharjee ◽  
Brandon M. Jones ◽  
James M. Hill ◽  
Christian Clement ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Precursor Protein ◽  
Macular Degeneration ◽  
Beta Amyloid ◽  
Precursor Protein ◽  
Age Related Macular Degeneration ◽  
Age Related

scholarly journals Investigation of an amyloid precursor protein protective mutation (A673T) in a North American case-control sample of late-onset Alzheimer's disease

2014 ◽  
Vol 35 (7) ◽  
pp. 1779.e15-1779.e16 ◽  
Author(s):  
Mikhil N. Bamne ◽  
F. Yesim Demirci ◽  
Sarah Berman ◽  
Beth E. Snitz ◽  
Samantha L. Rosenthal ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Precursor Protein ◽  
North American ◽  
Late Onset ◽  
Control Sample ◽  
Case Control ◽  
Precursor Protein ◽  
American Case
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