scholarly journals Cyclophilin B is really a major growth factor in breast milk

2022 ◽  
Vol 298 (1) ◽  
pp. 101481
Author(s):  
Olivier Delmas
Keyword(s):  
Growth Factor ◽  
Breast Milk ◽  
Cyclophilin B

scholarly journals Differentiation of Human Breast-Milk Stem Cells to Neural Stem Cells and Neurons

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Seyed Mojtaba Hosseini ◽  
Tahere Talaei-khozani ◽  
Mahsa Sani ◽  
Bahareh Owrangi
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Growth Factor ◽  
Breast Milk ◽  
Neural Stem Cells ◽  
Human Breast Milk ◽  
Stem Cell Markers ◽  
Human Breast ◽  
Fetal Bovine ◽  
Endothelial Growth Factor

Objectives.Human breast milk contains a heterogeneous population of cells that have the potential to provide a noninvasive source of cells for cell therapy in many neurodegenerative diseases without any ethical concern. The objectives of this study were to differentiate the breast milk-derived stem cells (BMDSC) toward neural stem cells and then into the neurons and neuroglia.Materials and Methods.To do this, the BMDSC were isolated from human breast milk and cultured in Dulbecco’s modified Eagle medium/F12 (DMEM/F12) containing fibroblast growth factor (bFGF). The cells were then characterized by evaluation of the embryonic and stem cell markers. Then, the cells were exposed to culture medium containing 1% B27 and 2% N2 for 7–10 days followed by medium supplemented with B27, N2, bFGF 10 µg/mL, and endothelial growth factor (EGF) 20 µg/mL. Then, the sphere-forming assay was performed. The spheres were then differentiated into three neural lineages by withdrawing growth factor in the presence of 5% FBS (fetal bovine serum). The immunofluorescence was done forβ-tubulin III, O4, and GFAP (glial fibrillary acidic protein).Results.The results indicated that the cells expressed both embryonic and mesenchymal stem cell (MSC) markers. They also showed neurospheres formation that was nestin-positive. The cells were also differentiated into all three neural lineages.Conclusion.The BMDSC can behave in the same way with neural stem cells. They were differentiated into oligodendrocytes, and astrocytes as well as neurons.

Hepatocyte Growth Factor in Human Breast Milk Acts as a Trophic Factor

2002 ◽  
Vol 34 (1) ◽  
pp. 16-20 ◽  
Author(s):  
H. Itoh ◽  
A. Itakura ◽  
O. Kurauchi ◽  
M. Okamura ◽  
H. Nakamura ◽  
...  
Keyword(s):  
Growth Factor ◽  
Breast Milk ◽  
Hepatocyte Growth Factor ◽  
Trophic Factor ◽  
Human Breast Milk ◽  
Human Breast ◽  
Hepatocyte Growth

scholarly journals Investigating the Relationship between Insulin-like Growth Factor-1 (IGF-1) in diabetic mother’s breast milk and the blood serum of their babies

10.19082/2546 ◽  
2016 ◽  
Vol 8 (6) ◽  
pp. 2546-2550 ◽  
Author(s):  
Abdel Hakeem Abdel Mohsen ◽  
Salem Sallam ◽  
Maggie M. Ramzy ◽  
Eman Kamel Hamed
Keyword(s):  
Growth Factor ◽  
Breast Milk ◽  
Blood Serum ◽  
Insulin Like Growth Factor ◽  
The Relationship

scholarly journals Serum Transforming Growth Factor Beta2 and Feeding Intolerance in Premature Formula -Fed versus Breast Milk-fed Neonates

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
R I H Ismail ◽  
W O A Othman ◽  
M A Abouwarda
Keyword(s):  
Growth Factor ◽  
Breast Milk ◽  
Serum Level ◽  
Transforming Growth Factor ◽  
Secondary Outcome ◽  
Preterm Neonates ◽  
Specific Marker ◽  
Feeding Intolerance ◽  
Preterm Formula ◽  
Elisa Technique

Abstract Serum Transforming Growth Factor Beta2 and Feeding Intolerance in Premature Formula -Fed versus Breast Milk-fed Neonates Objectives to assess occurance of feeding intolerance and NEC in relation to serum level of TGF-β2 in breast milk versus preterm formula fed neonates. Subjects and Methods a prospective observational study on 80 preterm neonates(≤36weeks gestational age). They were divided to two groups; breast milk fed group(n = 40) and preterm formula fed group(n = 40). They were assessed clinically for feeding intolerance and NEC and laboratory by measurement of TGF-β2 using ELISA technique. Results TGF-β2 serum level was significantly lower in preterm formula fed group than breast fed group;median(interquartile) 500(250-3000) pg/ml vs 7750(6500-11250) pg/ml (p < 0.0001). Both primary outcome(feeding intolerance and NEC) and secondary outcome(respiratory support and sepsis) were negatively correlated to TGF-β2 serum level. TGF-β2 serum level below 1250 pg/ml was found to be a good diagnostic test for feeding intolerance with sensitivity of 75.86% and specificity of 96.08%. Conclusion low serumTGF-β2 level is a specific marker for feeding intolerance in preterm neonate. Using premature formula in premature neonates is not recommended as it is associated with lower serum TGF-β2 and higher incidence of feeding intolerance compared to breast feeding.

scholarly journals Breast Milk Transforming Growth Factor β Is Associated With Neonatal Gut Microbial Composition

2017 ◽  
Vol 65 (3) ◽  
pp. e60-e67 ◽  
Author(s):  
Alexandra R. Sitarik ◽  
Kevin R. Bobbitt ◽  
Suzanne L. Havstad ◽  
Kei E. Fujimura ◽  
Albert M. Levin ◽  
...  
Keyword(s):  
Growth Factor ◽  
Breast Milk ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Microbial Composition
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