Tailored Trojan horse nanocarriers for enhanced redox-responsive drug delivery

2022 ◽  
Author(s):  
Yaru Li ◽  
Simin Feng ◽  
Peipei Dai ◽  
Fang Liu ◽  
Yaqi Shang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Trojan Horse ◽  
Redox Responsive

Redox-Responsive Drug Delivery

2014 ◽  
Vol 21 (5) ◽  
pp. 705-706 ◽  
Author(s):  
Marc A. Gauthier
Keyword(s):  
Drug Delivery ◽  
Redox Responsive

scholarly journals Trojan-Horse Nanotube On-Command Intracellular Drug Delivery

Nano Letters ◽  
2012 ◽  
Vol 12 (11) ◽  
pp. 5475-5480 ◽  
Author(s):  
Chia-Hsuan Wu ◽  
Cong Cao ◽  
Jin Ho Kim ◽  
Chih-Hsun Hsu ◽  
Harold J. Wanebo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Trojan Horse ◽  
Intracellular Drug Delivery

scholarly journals Redox‐Responsive Resilin‐Like Hydrogels for Tissue Engineering and Drug Delivery Applications

2019 ◽  
Vol 19 (8) ◽  
pp. 1900122 ◽  
Author(s):  
Renay S.‐C. Su ◽  
Richard J. Galas ◽  
Charng‐Yu Lin ◽  
Julie C. Liu
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Redox Responsive ◽  
Drug Delivery Applications

Redox Sensitive Polysaccharide Based Nanoparticles for Improved Cancer Treatment: A Comprehensive Review

2018 ◽  
Vol 24 (28) ◽  
pp. 3303-3319 ◽  
Author(s):  
Erfaneh Ghassami ◽  
Jaleh Varshosaz ◽  
Somayeh Taymouri
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Chemical Properties ◽  
Delivery Systems ◽  
Exchange Reactions ◽  
Triggered Release ◽  
Redox Responsive

Background: Among the numerous bio-responsive polymeric drug delivery systems developed recently, redox-triggered release of molecular payloads have gained great deal of attention, especially in the field of anticancer drug delivery. In most cases, these systems rely on disulfide bonds located either in the matrix crosslinks, or in auxiliary chains to achieve stimuli-responsive drug release. These bonds keep their stability in extracellular environments, yet, rapidly break by thiol–disulfide exchange reactions in the cytosol, due to the presence of greater levels of glutathione. Polysaccharides are macromolecules with low cost, natural abundance, biocompatibility, biodegradability, appropriate physical and chemical properties, and presence of numerous functional groups which facilitate chemical or physical cross-linking. Methods: With regards to the remarkable advantages of polysaccharides, in the current study, various polysaccharide-based redox-responsive drug delivery systems are reviewed. In most cases the in vitro/in vivo effects of the developed system were also evaluated. Results: Considering the hypoxic and reducing nature of the tumor microenvironment, with several folds higher glutathione levels than the systemic tissues, redox-sensitive polymeric systems could be implemented for tumorspecific drug delivery and the results of the previous researches in this field indicated satisfactory achievements. Conclusion: According to the reviewed papers, the efficiency of diverse redox-responsive polysaccharide-based nanoparticles with therapeutic payloads in cancer chemotherapy could be concluded. Nevertheless, more comprehensive studies are required to understand the exact intracellular and systemic fate of these nano-carriers, as well as their clinical efficacy for cancer treatment.

scholarly journals Doxorobicin as cargo in a redox-responsive drug delivery system capped with water dispersible ZnS nanoparticles

RSC Advances ◽  
2020 ◽  
Vol 10 (27) ◽  
pp. 15825-15835
Author(s):  
Lukáš Žid ◽  
Vladimír Zeleňák ◽  
Vladimír Girman ◽  
Jozef Bednarčík ◽  
Adriana Zeleňáková ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Delivery System ◽  
Capping Agent ◽  
Zns Nanoparticles ◽  
Water Dispersible ◽  
Redox Responsive ◽  
Premature Release

Redox-responsive drug delivery system was studied. ZnS nanoparticles served as pore capping agent to prevent premature release of anticancer drug. Such cargo can be monitored by magnetic field which opens possibilities its use in theranostics.

scholarly journals Advances in redox-responsive drug delivery systems of tumor microenvironment

2018 ◽  
Vol 16 (1) ◽  
Author(s):  
Xiaoshuang Guo ◽  
Yuan Cheng ◽  
Xiaotian Zhao ◽  
Yanli Luo ◽  
Jianjun Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Microenvironment ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Redox Responsive

A redox-responsive mesoporous silica nanoparticle capped with amphiphilic peptides by self-assembly for cancer targeting drug delivery

Nanoscale ◽  
2015 ◽  
Vol 7 (22) ◽  
pp. 10071-10077 ◽  
Author(s):  
Dong Xiao ◽  
Hui-Zhen Jia ◽  
Ning Ma ◽  
Ren-Xi Zhuo ◽  
Xian-Zheng Zhang
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Cancer Cells ◽  
Self Assembly ◽  
Silica Nanoparticle ◽  
Cancer Targeting ◽  
Mesoporous Silica Nanoparticle ◽  
Amphiphilic Peptides ◽  
Redox Responsive

A novel redox-responsive mesoporous silica nanoparticle (RRMSN/DOX) capped with amphiphilic peptides by self-assembly was demonstrated for targeting drug delivery in cancer cells.

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