Mesenchymal stem cells (MSCs) from adipose tissue in the repair of acute renal failure (ARF) induced by hyperuricemia

Cytotherapy ◽  
2018 ◽  
Vol 20 (5) ◽  
pp. S51
Author(s):  
R. Frezzatti ◽  
P.L. Alves ◽  
R.F. Alponti ◽  
P.F. Silveira
Keyword(s):  
Stem Cells ◽  
Renal Failure ◽  
Mesenchymal Stem Cells ◽  
Acute Renal Failure ◽  
Adipose Tissue

Mesenchymal stem cells derived from human umbilical cord ameliorate ischemia/reperfusion-induced acute renal failure in rats

2010 ◽  
Vol 32 (5) ◽  
pp. 725-732 ◽  
Author(s):  
Huiling Cao ◽  
Hui Qian ◽  
Wenrong Xu ◽  
Wei Zhu ◽  
Xu Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Renal Failure ◽  
Mesenchymal Stem Cells ◽  
Acute Renal Failure ◽  
Umbilical Cord ◽  
Ischemia Reperfusion ◽  
Human Umbilical Cord

MR Tracking of Magnetically Labeled Mesenchymal Stem Cells in Rat Kidneys with Acute Renal Failure

2008 ◽  
Vol 17 (3) ◽  
pp. 279-290 ◽  
Author(s):  
Jun-Hui Sun ◽  
Gao-Jun Teng ◽  
Sheng-Hong Ju ◽  
Zhan-Long Ma ◽  
Xiao-Li Mai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Renal Failure ◽  
Mesenchymal Stem Cells ◽  
Acute Renal Failure ◽  
Rat Kidneys

scholarly journals Administered mesenchymal stem cells enhance recovery from ischemia/reperfusion-induced acute renal failure in rats

2005 ◽  
Vol 68 (4) ◽  
pp. 1613-1617 ◽  
Author(s):  
Claudia Lange ◽  
Florian Tögel ◽  
Harald Ittrich ◽  
Frederic Clayton ◽  
Claus Nolte-Ernsting ◽  
...  
Keyword(s):  
Stem Cells ◽  
Renal Failure ◽  
Mesenchymal Stem Cells ◽  
Acute Renal Failure ◽  
Ischemia Reperfusion

Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms

2005 ◽  
Vol 289 (1) ◽  
pp. F31-F42 ◽  
Author(s):  
Florian Tögel ◽  
Zhuma Hu ◽  
Kathleen Weiss ◽  
Jorge Isaac ◽  
Claudia Lange ◽  
...  
Keyword(s):  
Stem Cells ◽  
Renal Failure ◽  
Mesenchymal Stem Cells ◽  
Acute Renal Failure ◽  
Ischemia Reperfusion ◽  
Kidney Injury ◽  
Clinical Problem ◽  
Cell Phenotype ◽  
Target Cells

Severe acute renal failure (ARF) remains a common, largely treatment-resistant clinical problem with disturbingly high mortality rates. Therefore, we tested whether administration of multipotent mesenchymal stem cells (MSC) to anesthetized rats with ischemia-reperfusion-induced ARF (40-min bilateral renal pedicle clamping) could improve the outcome through amelioration of inflammatory, vascular, and apoptotic/necrotic manifestations of ischemic kidney injury. Accordingly, intracarotid administration of MSC (∼ 106/animal) either immediately or 24 h after renal ischemia resulted in significantly improved renal function, higher proliferative and lower apoptotic indexes, as well as lower renal injury and unchanged leukocyte infiltration scores. Such renoprotection was not obtained with syngeneic fibroblasts. Using in vivo two-photon laser confocal microscopy, fluorescence-labeled MSC were detected early after injection in glomeruli, and low numbers attached at microvasculature sites. However, within 3 days of administration, none of the administered MSC had differentiated into a tubular or endothelial cell phenotype. At 24 h after injury, expression of proinflammatory cytokines IL-1β, TNF-α, IFN-γ, and inducible nitric oxide synthase was significantly reduced and that of anti-inflammatory IL-10 and bFGF, TGF-α, and Bcl-2 was highly upregulated in treated kidneys. We conclude that the early, highly significant renoprotection obtained with MSC is of considerable therapeutic promise for the cell-based management of clinical ARF. The beneficial effects of MSC are primarily mediated via complex paracrine actions and not by their differentiation into target cells, which, as such, appears to be a more protracted response that may become important in late-stage organ repair.

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