scholarly journals Innovative HIV-1-specific CD8+ T-cell epitopes revealed in human recipients of conserved-proteome T-cell vaccine

2019 ◽  
Vol 12 (1) ◽  
pp. 148
Author(s):  
Y. Mohamed ◽  
T. Hanke
Keyword(s):  
T Cell ◽  
Cd8 T Cell ◽  
Cell Vaccine ◽  
T Cell Epitopes ◽  
T Cell Vaccine ◽  
Hiv 1

scholarly journals Sampling SARS-CoV-2 Proteomes for Predicted CD8 T-Cell Epitopes as a Tool for Understanding Immunogenic Breadth and Rational Vaccine Design

2021 ◽  
Vol 1 ◽  
Author(s):  
Jonathan Hare ◽  
David Morrison ◽  
Morten Nielsen
Keyword(s):  
T Cell ◽  
Therapeutic Vaccine ◽  
Vaccine Design ◽  
Cd8 T Cell ◽  
Cell Vaccine ◽  
T Cell Epitopes ◽  
Global Pandemic ◽  
T Cell Vaccine ◽  
Rational Vaccine Design ◽  
Global And Local

Predictive models for vaccine design have become a powerful and necessary resource for the expeditiousness design of vaccines to combat the ongoing SARS-CoV-2 global pandemic. Here we use the power of these predicted models to assess the sequence diversity of circulating SARS-CoV-2 proteomes in the context of an individual’s CD8 T-cell immune repertoire to identify potential. defined regions of immunogenicity. Using this approach of expedited and rational CD8 T-cell vaccine design, it may be possible to develop a therapeutic vaccine candidate with the potential for both global and local coverage.

Phase I Clinical Trial HIV-CORE002 of a Universal T-cell Vaccine: Mapping of CD8+ T Cell Epitopes

2014 ◽  
Vol 30 (S1) ◽  
pp. A187-A187 ◽  
Author(s):  
Nicola J. Borthwick ◽  
Tina Ahmed ◽  
Lucy Dorrell ◽  
Andy Van Hateren ◽  
Tim Elliot ◽  
...  
Keyword(s):  
Clinical Trial ◽  
T Cell ◽  
Phase I ◽  
Cd8 T Cell ◽  
Phase I Clinical Trial ◽  
Cell Vaccine ◽  
T Cell Epitopes ◽  
T Cell Vaccine

scholarly journals Sampling SARS-CoV-2 proteomes for predicted CD8 T-cell epitopes as a tool for understanding immunogenic breadth and rational vaccine design

2020 ◽  
Author(s):  
Jonathan Hare ◽  
David Morrison ◽  
Morten Nielsen
Keyword(s):  
T Cell ◽  
Therapeutic Vaccine ◽  
Vaccine Design ◽  
Cd8 T Cell ◽  
Cell Vaccine ◽  
T Cell Epitopes ◽  
Global Pandemic ◽  
T Cell Vaccine ◽  
Rational Vaccine Design ◽  
Global And Local

AbstractPredictive models for vaccine design have become a powerful and necessary resource for the expeditiousness design of vaccines to combat the ongoing SARS-CoV-2 global pandemic. Here we use the power of these predicted models to assess the sequence diversity of circulating SARS-CoV-2 proteomes in the context of an individual’s CD8 T-cell immune repertoire to identify potential. defined regions of immunogenicity. Using this approach of expedited and rational CD8 T-cell vaccine design, it may be possible to develop a therapeutic vaccine candidate with the potential for both global and local coverage.

scholarly journals Potent HIV-1-Specific CD8 T Cell Responses Induced in Mice after Priming with a Multiepitopic DNA-TMEP and Boosting with the HIV Vaccine MVA-B

Viruses ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 424 ◽  
Author(s):  
Beatriz Perdiguero ◽  
Suresh C. Raman ◽  
Cristina Sánchez-Corzo ◽  
Carlos Oscar S. Sorzano ◽  
José Ramón Valverde ◽  
...  
Keyword(s):  
T Cell ◽  
Immune Responses ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Effective Vaccine ◽  
T Cell Epitopes ◽  
Cell Responses ◽  
Modified Vaccinia Virus Ankara ◽  
Hiv 1

An effective vaccine against Human Immunodeficiency Virus (HIV) still remains the best solution to provide a sustainable control and/or eradication of the virus. We have previously generated the HIV-1 vaccine modified vaccinia virus Ankara (MVA)-B, which exhibited good immunogenicity profile in phase I prophylactic and therapeutic clinical trials, but was unable to prevent viral rebound after antiretroviral (ART) removal. To potentiate the immunogenicity of MVA-B, here we described the design and immune responses elicited in mice by a new T cell multi-epitopic B (TMEP-B) immunogen, vectored by DNA, when administered in homologous or heterologous prime/boost regimens in combination with MVA-B. The TMEP-B protein contained conserved regions from Gag, Pol, and Nef proteins including multiple CD4 and CD8 T cell epitopes functionally associated with HIV control. Heterologous DNA-TMEP/MVA-B regimen induced higher HIV-1-specific CD8 T cell responses with broader epitope recognition and higher polyfunctional profile than the homologous DNA-TMEP/DNA-TMEP or the heterologous DNA-GPN/MVA-B combinations. Moreover, higher HIV-1-specific CD4 and Tfh immune responses were also detected using this regimen. After MVA-B boost, the magnitude of the anti-VACV CD8 T cell response was significantly compromised in DNA-TMEP-primed animals. Our results revealed the immunological potential of DNA-TMEP prime/MVA-B boost regimen and supported the application of these combined vectors in HIV-1 prevention and/or therapy.

scholarly journals A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape

Retrovirology ◽  
2015 ◽  
Vol 12 (1) ◽  
Author(s):  
Henrik N Kløverpris ◽  
David K Cole ◽  
Anna Fuller ◽  
Jonathan Carlson ◽  
Konrad Beck ◽  
...  
Keyword(s):  
T Cell ◽  
Cd8 T Cell ◽  
Molecular Switch ◽  
T Cell Epitopes ◽  
Hiv 1

scholarly journals Immune hierarchy among HIV-1 CD8+T cell epitopes delivered by dendritic cells depends on MHC-I binding irrespective of mode of loading and immunization in HLA-A*0201 mice

Apmis ◽  
2009 ◽  
Vol 117 (11) ◽  
pp. 849-855 ◽  
Author(s):  
HENRIK N. KLOVERPRIS ◽  
INGRID KARLSSON ◽  
METTE THORN ◽  
SØREN BUUS ◽  
ANDERS FOMSGAARD
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cd8 T Cell ◽  
T Cell Epitopes ◽  
Mhc I ◽  
Hiv 1

Novel approaches in polyepitope T-cell vaccine development against HIV-1

2013 ◽  
Vol 13 (1) ◽  
pp. 155-173 ◽  
Author(s):  
Larisa I Karpenko ◽  
Sergei I Bazhan ◽  
Denis V Antonets ◽  
Igor M Belyakov
Keyword(s):  
T Cell ◽  
Vaccine Development ◽  
Cell Vaccine ◽  
T Cell Vaccine ◽  
Novel Approaches ◽  
Hiv 1

scholarly journals Is a Human CD8 T-Cell Vaccine Possible, and if So, What Would It Take?

2017 ◽  
Vol 10 (9) ◽  
pp. a028910 ◽  
Author(s):  
Lalit K. Beura ◽  
Stephen C. Jameson ◽  
David Masopust
Keyword(s):  
T Cell ◽  
Cd8 T Cell ◽  
Cell Vaccine ◽  
T Cell Vaccine

scholarly journals Biopolymer encapsulated live influenza virus as a universal CD8+ T cell vaccine against influenza virus

Vaccine ◽  
2010 ◽  
Vol 29 (2) ◽  
pp. 314-322 ◽  
Author(s):  
Alina C. Boesteanu ◽  
Nadarajan S. Babu ◽  
Margaret Wheatley ◽  
Elisabeth S. Papazoglou ◽  
Peter D. Katsikis
Keyword(s):  
Influenza Virus ◽  
T Cell ◽  
Cd8 T Cell ◽  
Cell Vaccine ◽  
T Cell Vaccine

scholarly journals Utilizing Computational Machine Learning Tools to Understand Immunogenic Breadth in the Context of a CD8 T-Cell Mediated HIV Response

2020 ◽  
Author(s):  
Ed McGowan ◽  
Rachel Rosenthal ◽  
Andrew Fiore-Gartland ◽  
Gladys Macharia ◽  
Sheila Balinda ◽  
...  
Keyword(s):  
T Cell ◽  
Vaccine Design ◽  
Cd8 T Cell ◽  
Cell Vaccine ◽  
Learning Tools ◽  
T Cell Vaccine ◽  
Novel Approach ◽  
Low Prevalence ◽  
Global And Local

ABSTRACTPredictive models are becoming more and more commonplace as tools for candidate antigen discovery to meet the challenges of enabling epitope mapping of cohorts with diverse HLA properties. Here we build on the concept of using two key parameters, diversity metric of the HLA profile of individuals within a population and consideration of sequence diversity in the context of an individual’s CD8 T-cell immune repertoire to assess the HIV proteome for defined regions of immunogenicity. Using this approach, Analysis of HLA adaptation and functional immunogenicity data enabled the identification of regions within the proteome that offer significant conservation, HLA recognition within a population, low prevalence of HLA adaptation and demonstrated immunogenicity. We believe this unique and novel approach to vaccine design that, in combination with in vitro functional assays, offers a bespoke pipeline for expedited and rational CD8 T-cell vaccine design for HIV and potentially other pathogens with the potential for both global and local coverage.

Sign in / Sign up

Export Citation Format

Share Document