Vasomotor reactivity in mild cognitive impairment—A study with transcranial Doppler sonography

ZusammenfassungBei 29 Patienten (3 Kontrollpersonen, 26 Patienten mit zerebrovaskulärer Erkrankung) wurde prospektiv die Hirn-SPECT mit 99mTC-HMPAO und bei 20 Patienten (3 Kontrollpersonen, 17 Patienten mit ZVK) die transkranielle Dopplersonographie (TCD) vor und nach i. v. Gabe von Azetazolamid durchgeführt. Die Sensitivität der Hirn-SPECT erhöhte sich mit Azetazolamid von 62% auf 77%. Bei Patienten mit reversiblem neurologischem Defizit wurde eine Verbesserung von 50% auf 71 %, bei Patienten mit persistierendem Defizit von 75% auf 83% beobachtet. Die Ergebnisse der Hirn-SPECT und der TCD stimmten in der Beurteilung der zerebro-vaskulären Reservekapazität in 91% der Hemisphären überein. Die Korrelation zwischen den beiden Methoden war statistisch signifikant.

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Investigating multidimensionality of language lateralisation in left and right handed adults: an update on Woodhead et al. 2019

10.31234/osf.io/mrkgf ◽

2020 ◽

Author(s):

Zoe Victoria Joan Woodhead ◽

Paul Andrew Thompson ◽

Emma Karlsson ◽

Dorothy Vera Margaret Bishop

Keyword(s):

Transcranial Doppler ◽

Structural Equation Modelling ◽

Structural Equation ◽

Doppler Sonography ◽

Factor Model ◽

Transcranial Doppler Sonography ◽

Group Level ◽

Equation Modelling ◽

Left And Right ◽

Functional Transcranial Doppler Sonography

A previous study we reported in this journal suggested that left and right handers may differ in their patterns of lateralisation for different language tasks. However, it had too few left handers (N=7) to reach any conclusions. For this update paper, further participants were added to the sample to create separate groups of left (N=31) and right handers (N=43). Two hypotheses were tested: 1) that lateralisation would be weaker at the group level in left than right handers; and 2) that left handers would show weaker covariance in lateralisation between tasks, supporting a two factor model.All participants performed the same protocol as in our previous paper: lateralisation was measured using functional transcranial Doppler sonography during six different language tasks, on two separate testing sessions. The results supported hypothesis 1, with significant differences in laterality between groups for four out of six tasks. For hypothesis 2, structural equation modelling showed that there was stronger evidence for a two factor model in left than right handers; furthermore, examination of the factor loadings suggested that the pattern of laterality across tasks may also differ between handedness groups. These results expand on what is known about the differences in laterality between left and right handers.

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Faculty Opinions recommendation of Accuracy of cerebral monitoring in detecting cerebral ischemia during carotid endarterectomy: a comparison of transcranial Doppler sonography, near-infrared spectroscopy, stump pressure, and somatosensory evoked potentials.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1092305.554096 ◽

2007 ◽

Author(s):

Luzius A Steiner

Keyword(s):

Infrared Spectroscopy ◽

Cerebral Ischemia ◽

Near Infrared Spectroscopy ◽

Somatosensory Evoked Potentials ◽

Transcranial Doppler ◽

Near Infrared ◽

Doppler Sonography ◽

Transcranial Doppler Sonography ◽

Stump Pressure ◽

Cerebral Monitoring

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Ubiquinol Supplementation Improves Gender-Dependent Cerebral Vasoreactivity and Ameliorates Chronic Inflammation and Endothelial Dysfunction in Patients with Mild Cognitive Impairment

Antioxidants ◽

10.3390/antiox10020143 ◽

2021 ◽

Vol 10 (2) ◽

pp. 143

Author(s):

Sonia García-Carpintero ◽

Javier Domínguez-Bértalo ◽

Cristina Pedrero-Prieto ◽

Javier Frontiñán-Rubio ◽

Mariano Amo-Salas ◽

...

Keyword(s):

Endothelial Cells ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Vascular Dysfunction ◽

Transcranial Doppler Sonography ◽

Endothelial Damage ◽

Microvascular Endothelial Cell ◽

Neurological Improvement ◽

Male Patients ◽

Cerebral Vasoreactivity

Ubiquinol can protect endothelial cells from multiple mechanisms that cause endothelial damage and vascular dysfunction, thus contributing to dementia. A total of 69 participants diagnosed with mild cognitive impairment (MCI) received either 200 mg/day ubiquinol (Ub) or placebo for 1 year. Cognitive assessment of patients was performed at baseline and after 1 year of follow-up. Patients’ cerebral vasoreactivity was examined using transcranial Doppler sonography, and levels of Ub and lipopolysaccharide (LPS) in plasma samples were quantified. Cell viability and necrotic cell death were determined using the microvascular endothelial cell line bEnd3. Coenzyme Q10 (CoQ) levels increased in patients supplemented for 1 year with ubiquinol versus baseline and the placebo group, although higher levels were observed in male patients. The higher cCoQ concentration in male patients improved cerebral vasoreactivity CRV and reduced inflammation, although the effect of Ub supplementation on neurological improvement was negligible in this study. Furthermore, plasma from Ub-supplemented patients improved the viability of endothelial cells, although only in T2DM and hypertensive patients. This suggests that ubiquinol supplementation could be recommended to reach a concentration of 5 μg/mL in plasma in MCI patients as a complement to conventional treatment.

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