Heat shock protein 72 inhibits c-Jun N-terminal kinase 3 signaling pathway via Akt1 during cerebral ischemia

2012 ◽  
Vol 317 (1-2) ◽  
pp. 123-129 ◽  
Author(s):  
Dashi Qi ◽  
Hongzhi Liu ◽  
Jian Niu ◽  
Xing Fan ◽  
Xiangru Wen ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Signaling Pathway ◽  
Heat Shock Protein 72

scholarly journals Heat shock protein 72 (Hsp72) improves long term recovery after focal cerebral ischemia in mice

2011 ◽  
Vol 488 (3) ◽  
pp. 279-282 ◽  
Author(s):  
Lijun Xu ◽  
Xiaoxing Xiong ◽  
Yibing Ouyang ◽  
George Barreto ◽  
Rona Giffard
Keyword(s):  
Cerebral Ischemia ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Focal Cerebral Ischemia ◽  
Heat Shock Protein 72

Abstract WMP77: Combination of Metabolic and Transcriptional Profiling Identifies Pentose Phosphate Pathway Activation by Heat Shock Protein 27 Phosphorylation During Cerebral Ischemia

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Yusuke Yamamoto ◽  
Kohkichi Hosoda ◽  
Taichiro Imahori ◽  
Yasuhiro Irino ◽  
Masakazu Shinohara ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Signaling Pathway ◽  
Pentose Phosphate Pathway ◽  
Transcriptional Profiling ◽  
Mapk Signaling ◽  
Pentose Phosphate ◽  
Rt Pcr ◽  
Hsp27 Phosphorylation

Objectives: The metabolic pathophysiology of ischemic stroke remains poorly understood. We performed a comparative omics analysis to identify the effects of cerebral ischemia on metabolism of cerebral cortex in the rat model with middle cerebral artery occlusion (MCAO). Methods: MCAO was induced with suture occlusion technique. After the desired period of MCAO (30, 60, 120min), the rats were sacrificed. Tissue samples from the ischemic lesion were collected. Sham operated rats were treated in the same way except MCAO. Water-soluble metabolites were extracted and measured by gas-chromatography/mass-spectrometry (GC/MS). The obtained data were analyzed using multivariate statistics to explore metabolic pathways involved in ischemia. The associated metabolic enzymes were investigated with real-time polymerase chain reaction (RT-PCR) and Immunoblot analysis. Results: Metabolic profiling by GC/MS analysis showed clear separation between the ischemia and control group (Figure A, B). The decrease of fructose 6-phosphate and ribulose 5-phosphate suggested enhancement of the pentose phosphate pathway (PPP) during cerebral ischemia. Transcriptional profiling by microarray hybridization indicated that Toll-like receptor and mitogen-activated protein kinase (MAPK) signaling pathway were upregulated during cerebral ischemia. In relation to PPP, upregulation of heat shock protein 27 (HSP27) was observed in the MAPK signaling pathway and was confirmed through RT-PCR. Immunoblotting showed a slight increase in HSP27 protein expression and a marked increase in HSP27 phosphorylation (FigureC). Corresponding upregulation of glucose 6-phosphate dehydrogenase (G6PD) activity and an increase in the NADPH/NAD+ ratio were also observed (Figure D, E). Conclusions: G6PD activation via ischemia-induced HSP27 phosphorylation may be part of an endogenous antioxidant neuroprotection mechanism during the earliest stages of ischemia.

Selectively Sensitizing Malignant Cells to Photothermal Therapy Using a CD44-Targeting Heat Shock Protein 72 Depletion Nanosystem

ACS Nano ◽  
2016 ◽  
Vol 10 (9) ◽  
pp. 8578-8590 ◽  
Author(s):  
Shouju Wang ◽  
Ying Tian ◽  
Wei Tian ◽  
Jing Sun ◽  
Shuang Zhao ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Photothermal Therapy ◽  
Malignant Cells ◽  
Heat Shock Protein 72 ◽  
Cd44 Targeting

scholarly journals Hypertension, aging, and myocardial synthesis of heat-shock protein 72.

Hypertension ◽  
1994 ◽  
Vol 24 (5) ◽  
pp. 620-624 ◽  
Author(s):  
M Bongrazio ◽  
L Comini ◽  
G Gaia ◽  
T Bachetti ◽  
R Ferrari
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 72

scholarly journals L-NAME Treatment Enhances Exercise-induced Content of Myocardial Heat Shock Protein 72 (Hsp72) in Rats

2011 ◽  
Vol 27 (5) ◽  
pp. 479-486 ◽  
Author(s):  
Wellington Lunz ◽  
Luciano S.A. Capettini ◽  
Ana P.C. Davel ◽  
Carolina D. Munhoz ◽  
Josiane F. da Silva ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 72 ◽  
Exercise Induced

scholarly journals Heat Shock Protein 72 Is Associated with the Hepatitis C Virus Replicase Complex and Enhances Viral RNA Replication

2010 ◽  
Vol 285 (36) ◽  
pp. 28183-28190 ◽  
Author(s):  
Yin-Ju Chen ◽  
Yu-Hsuan Chen ◽  
Lu-Ping Chow ◽  
Ya-Hui Tsai ◽  
Pei-Hong Chen ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Rna Replication ◽  
Viral Rna ◽  
Heat Shock Protein 72 ◽  
Replicase Complex

scholarly journals Exercise induces hepatosplanchnic release of heat shock protein 72 in humans

2002 ◽  
Vol 544 (3) ◽  
pp. 957-962 ◽  
Author(s):  
Mark A. Febbraio ◽  
Peter Ott ◽  
Henning Bay Nielsen ◽  
Adam Steensberg ◽  
Charlotte Keller ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 72
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