Different clinical and vascular risk factors of mild cognitive impairment, and dementia in Parkinson’s disease

2017 ◽  
Vol 381 ◽  
pp. 1036
Author(s):  
R. Tanaka ◽  
K. Yamashiro ◽  
G. Oyama ◽  
K. Nishioka ◽  
A. Umemura ◽  
...  
Keyword(s):  
Risk Factors ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Vascular Risk Factors ◽  
Vascular Risk

Vascular risk factors do not contribute to motor and cognitive impairment in Parkinson's disease

2010 ◽  
Vol 16 (1) ◽  
pp. 73-74 ◽  
Author(s):  
J. Sławek ◽  
D. Wieczorek ◽  
M. Derejko ◽  
M. Dubaniewicz ◽  
B. Brockhuis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Vascular Risk Factors ◽  
Vascular Risk

Analyses of Visuospatial and Visuoperceptual Errors as Predictors of Dementia in Parkinson’s Disease Patients with Subjective Cognitive Decline and Mild Cognitive Impairment

2020 ◽  
pp. 1-11
Author(s):  
Iván Galtier ◽  
Antonieta Nieto ◽  
María Mata ◽  
Jesús N. Lorenzo ◽  
José Barroso
Keyword(s):  
Risk Factors ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Decline ◽  
Poor Performance ◽  
Subjective Cognitive Decline ◽  
Independent Risk Factors

ABSTRACT Objective: Subjective cognitive decline (SCD) and mild cognitive impairment (MCI) in Parkinson’s disease (PD) are considered as the risk factors for dementia (PDD). Posterior cortically based functions, such as visuospatial and visuoperceptual (VS-VP) processing, have been described as predictors of PDD. However, no investigations have focused on the qualitative analysis of the Judgment of Line Orientation Test (JLOT) and the Facial Recognition Test (FRT) in PD-SCD and PD-MCI. The aim of this work was to study the VS-VP errors in JLOT and FRT. Moreover, these variables are considered as predictors of PDD. Method: Forty-two PD patients and 19 controls were evaluated with a neuropsychological protocol. Patients were classified as PD-SCD and PD-MCI. Analyses of errors were conducted following the procedure described by Ska, Poissant, and Joanette (1990). Follow-up assessment was conducted to a mean of 7.5 years after the baseline. Results: PD-MCI patients showed a poor performance in JLOT and FRT total score and made a greater proportion of severe intraquadrant (QO2) and interquadrant errors (IQO). PD-SCD showed a poor performance in FRT and made mild errors in JLOT. PD-MCI and QO2/IQO errors were independent risk factors for PDD during the follow-up. Moreover, the combination of both PD-MCI diagnosis and QO2/IQO errors was associated with a greater risk. Conclusions: PD-MCI patients presented a greater alteration in VS-VP processing observable by the presence of severe misjudgments. PD-SCD patients also showed mild difficulties in VS-SP functions. Finally, QO2/IQO errors in PD-MCI are a useful predictor of PDD, more than PD-MCI diagnosis alone.

scholarly journals Mild cognitive impairment: Incidence and vascular risk factors in a population-based cohort

Neurology ◽  
2013 ◽  
Vol 80 (23) ◽  
pp. 2112-2120 ◽  
Author(s):  
M. Ganguli ◽  
B. Fu ◽  
B. E. Snitz ◽  
T. F. Hughes ◽  
C.-C. H. Chang
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Population Based ◽  
Vascular Risk Factors ◽  
Vascular Risk

scholarly journals Aggregation of Vascular Risk Factors Modulates the Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment Patients

2020 ◽  
Vol 12 ◽  
Author(s):  
Liying Zhuang ◽  
Huafu Ni ◽  
Junyang Wang ◽  
Xiaoyan Liu ◽  
Yajie Lin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Brain Activity ◽  
Low Frequency ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Cvd Risk ◽  
Spontaneous Brain Activity ◽  
Main Effect

Background: Several vascular risk factors, including hypertension, diabetes, body mass index, and smoking status are found to be associated with cognitive decline and the risk of Alzheimer's disease (AD). We aimed to investigate whether an aggregation of vascular risk factors modulates the amplitude of low-frequency fluctuation (ALFF) in patients with mild cognitive impairment (MCI).Methods: Forty-three MCI patients and twenty-nine healthy controls (HCs) underwent resting-state functional MRI scans, and spontaneous brain activity was measured by the ALFF technique. The vascular risk profile was represented with the Framingham Heart Study general cardiovascular disease (FHS-CVD) risk score, and each group was further divided into high and low risk subgroups. Two-way ANOVA was performed to explore the main effects of diagnosis and vascular risk and their interaction on ALFF.Results: The main effect of diagnosis on ALFF was found in left middle temporal gyrus (LMTG) and left superior parietal gyrus (LSPG), and the main effect of risk on ALFF was detected in left fusiform gyrus (LFFG), left precuneus (LPCUN), and left cerebellum posterior lobe (LCPL). Patients with MCI exhibited increased ALFF in the LMTG and LSPG than HCs, and participants with high vascular risk showed increased ALFF in the LFFG and LCPL, while decreased ALFF in the LPCUN. An interaction between diagnosis (MCI vs. HC) and FHS-CVD risk (high vs. low) regarding ALFF was observed in the left hippocampus (LHIP). HCs with high vascular risk showed significantly increased ALFF in the LHIP than those with low vascular risk, while MCI patients with high vascular risk showed decreased ALFF in the LHIP than HCs with high vascular risk. Interestingly, the mean ALFF of LHIP positively correlated with word recall test in HCs with high vascular risk (rho = 0.630, P = 0.016), while negatively correlated with the same test in MCI patients with high vascular risk (rho = −0.607, P = 0.001).Conclusions: This study provides preliminary evidence highlighting that the aggregation of vascular risk factors modulates the spontaneous brain activity in MCI patients, and this may serve as a potential imaging mechanism underlying vascular contribution to AD.

scholarly journals Mild cognitive impairment in Parkinson's disease and vascular risk factors among Indian patients

2015 ◽  
Vol 27 (12) ◽  
pp. 2098-2099
Author(s):  
Vikas Dhikav ◽  
Mansi Sethi ◽  
Kuljeet Singh Anand
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Daily Living ◽  
Activity Of Daily Living ◽  
Vascular Risk ◽  
Subjective Memory Complaints ◽  
Subjective Memory ◽  
Indian Patients

Mild cognitive impairment (MCI) is often defined as subjective memory complaints with intact activity of daily living without dementia. Its association as a precursor to Alzheimer's disease is well known. However, MCI in Parkinson's disease (PD) is poorly understood. The present small study aimed to measure the frequency of MCI and vascular factors in Indian patients with PD.

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