Critical-size defect augmentation using sintered and non-sintered bovine bone matrix – an experimental controlled study in minipigs

2021 ◽  
Author(s):  
Dr. med. Dr. med. dent. Lara Schorn ◽  
Tim Fienitz ◽  
Francesco De Donno ◽  
Anja Sterner-Kock ◽  
Alexandra C. Maul ◽  
...  
Keyword(s):  
Critical Size ◽  
Bone Matrix ◽  
Controlled Study ◽  
Bovine Bone ◽  
Critical Size Defect

scholarly journals The use of solvent-preserved human and bovine cancellous bone blocks for lateral defect augmentation - an experimental controlled study in vivo

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Lara Schorn ◽  
Tim Fienitz ◽  
Kathrin Berndsen ◽  
Norbert R. Kübler ◽  
Henrik Holtmann ◽  
...  
Keyword(s):  
Bone Formation ◽  
Cancellous Bone ◽  
Bone Substitute ◽  
Bone Matrix ◽  
Human Bone ◽  
Controlled Study ◽  
Bovine Bone ◽  
New Bone Formation ◽  
Bone Substitute Material ◽  
Substitute Material

Abstract Background The aim of this study was to compare new bone formation, resorbed bone matrix, and fibrous enclosed residual bone substitute material in laterally augmented alveolar bone defects using allogeneic, pre-treated and cleaned human bone blocks (tested in dogs, therefore considered to be xenogeneic), and pre-treated and cleaned bovine cancellous bone blocks, both with and without a collagen membrane in order to evaluate their augmentative potential. Methods Thirty-two critical size horizontal defects were prepared in the mandible of 4 adult foxhound dogs (8 per dog, 4 on each side). After 3 months of healing, the defects were laterally augmented in a split-mouth-design with either human (HXB) or bovine solvent-preserved bone blocks (BXB). Afterwards, defects were randomly covered with a bovine collagenous membrane (HXB + M, BXB + M). After a healing interval of 6 months, percentages of new bone formation, resorbed bone matrix, and fibrous enclosed residual bone substitute material were compared. Results Results showed little new bone formation of up to 3.7 % in human bone blocks (HXB 3.7 % ± 10.2, HXB + M 0.3 %± 0.4, BXB, 0.1 % ± 0.8, BXB + M 2.6 % ± 3.2, p = > 0.05). Percentages of fibrous encapsulation were higher in human bone blocks than in bovine bone blocks (HXB 71.2 % ± 8.6, HXB + M 73.71 % ± 10.6, BXB, 60.5 % ± 27.4, BXB + M 52.5 % ± 28.4, p = > 0.05). Resorption rates differed from 44.8 % in bovine bone blocks covered with a membrane to 17.4 % in human bone blocks (HXB 17.4 % ± 7.4, HXB + M 25.9 % ± 10.7, BXB, 38.4 % ± 27.2, BXB + M 44.8 % ± 29.6, p = > 0.05). The use of additional membranes did not significantly affect results. Conclusions Within its limitations, results of this study suggest that solvent-preserved xenogenic human and bovine bone blocks are not suitable for lateral bone augmentation in dogs. Furthermore, defect coverage with a membrane does not positively affect the outcome.

scholarly journals Freeze Dried Bone Matrix on Rat Critical Size Defect Regeneration

2014 ◽  
Vol 23 (2) ◽  
pp. 233-238
Author(s):  
María V. Jammal ◽  
Liliana R. Missana ◽  
Kiyofumi Takabatake ◽  
Shin Takagi ◽  
Hitoshi Nagatsuka
Keyword(s):  
Critical Size ◽  
Bone Matrix ◽  
Critical Size Defect ◽  
Freeze Dried

scholarly journals Osteoformation potential of an allogenic partially demineralized bone matrix in critical-size defects in the rat calvarium

2021 ◽  
pp. 112207
Author(s):  
Ahmad Moustapha Diallo ◽  
Solène Rota ◽  
Michel Boissière ◽  
Raphaël Bardonnet ◽  
Emmanuel Pauthe ◽  
...  
Keyword(s):  
Critical Size ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Critical Size Defects ◽  
Demineralized Bone

PTH1-34 improves devitalized allogenic bone graft healing in a murine femoral critical size defect

Injury ◽  
2021 ◽  
Author(s):  
Tito Rocha ◽  
Amanda S. Cavalcanti ◽  
Ana Carolina Leal ◽  
Rhayra B. Dias ◽  
Rafaela Sartore da Costa ◽  
...  
Keyword(s):  
Bone Graft ◽  
Critical Size ◽  
Critical Size Defect ◽  
Allogenic Bone ◽  
Graft Healing ◽  
Allogenic Bone Graft
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