Association of polymorphisms of the tryptophan hydroxylase 2 gene with risk for bipolar disorder or suicidal behavior

2010 ◽  
Vol 44 (5) ◽  
pp. 271-274 ◽  
Author(s):  
Simone Becho Campos ◽  
Débora Marques Miranda ◽  
Bruno Rezende Souza ◽  
Patricia Araújo Pereira ◽  
Fernando Silva Neves ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Suicidal Behavior ◽  
Tryptophan Hydroxylase ◽  
Tryptophan Hydroxylase 2

Tryptophan hydroxylase 2 gene expression and promoter polymorphisms in bipolar disorder and schizophrenia

2005 ◽  
Vol 183 (3) ◽  
pp. 378-382 ◽  
Author(s):  
Vincenzo De Luca ◽  
Olga Likhodi ◽  
Hubert H. M. Van Tol ◽  
James L. Kennedy ◽  
Albert H. C. Wong
Keyword(s):  
Gene Expression ◽  
Bipolar Disorder ◽  
Tryptophan Hydroxylase ◽  
Promoter Polymorphisms ◽  
Tryptophan Hydroxylase 2

scholarly journals Association of Functional Polymorphisms of the Human Tryptophan Hydroxylase 2 Gene With Risk for Bipolar Disorder in Han Chinese

2007 ◽  
Vol 64 (9) ◽  
pp. 1015 ◽  
Author(s):  
Yi-Mei J. Lin ◽  
Shin-Chih Chao ◽  
Tsung-Ming Chen ◽  
Te-Jen Lai ◽  
Jia-Shing Chen ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Tryptophan Hydroxylase ◽  
Han Chinese ◽  
Tryptophan Hydroxylase 2 ◽  
Functional Polymorphisms

Association study of tryptophan hydroxylase 2 gene polymorphisms in bipolar disorder patients with panic disorder comorbidity

2011 ◽  
Vol 21 (2) ◽  
pp. 106-111 ◽  
Author(s):  
Simone Becho Campos ◽  
Débora M. Miranda ◽  
Bruno R. Souza ◽  
Patricia A. Pereira ◽  
Fernando S. Neves ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Panic Disorder ◽  
Association Study ◽  
Gene Polymorphisms ◽  
Tryptophan Hydroxylase ◽  
Tryptophan Hydroxylase 2

Serotonergic Genes and Suicidality

Crisis ◽  
2001 ◽  
Vol 22 (2) ◽  
pp. 54-60 ◽  
Author(s):  
Lisheng Du ◽  
Gabor Faludi ◽  
Miklos Palkovits ◽  
David Bakish ◽  
Pavel D. Hrdina
Keyword(s):  
Suicidal Ideation ◽  
Suicidal Behavior ◽  
Tryptophan Hydroxylase ◽  
Association Studies ◽  
Receptor Gene ◽  
Brain Regions ◽  
Depressive Illness ◽  
Control Group ◽  
Serotonergic Activity ◽  
Completed Suicide

Summary: Several lines of evidence indicate that abnormalities in the functioning of the central serotonergic system are involved in the pathogenesis of depressive illness and suicidal behavior. Studies have shown that the number of brain and platelet serotonin transporter binding sites are reduced in patients with depression and in suicide victims, and that the density of 5-HT2A receptors is increased in brain regions of depressed in suicide victims and in platelets of depressed suicidal patients. Genes that code for proteins, such as tryptophan hydroxylase, 5-HT transporter, and 5-HT2A receptor, involved in regulating serotonergic neurotransmission, have thus been major candidate genes for association studies of suicide and suicidal behavior. Recent studies by our group and by others have shown that genetic variations in the serotonin-system-related genes might be associated with suicidal ideation and completed suicide. We have shown that the 102 C allele in 5-HT2A receptor gene was significantly associated with suicidal ideation (χ2 = 8.5, p < .005) in depressed patients. Patients with a 102 C/C genotype had a significantly higher mean HAMD item #3 score (indication of suicidal ideation) than T/C or T/T genotype patients. Our results suggest that the 102T/C polymorphism in 5-HT2A receptor gene is primarily associated with suicidal ideation in patients with major depression and not with depression itself. We also found that the 5-HT transporter gene S/L polymorphism was significantly associated with completed suicide. The frequency of the L/L genotype in depressed suicide victims was almost double of that found in control group (48.6% vs. 26.2%). The odds ratio for the L allele was 2.1 (95% CI 1.2-3.7). The association between polymorphism in serotonergic genes and suicidality supports the hypothesis that genetic factors can modulate suicide risk by influencing serotonergic activity.

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