Effect of OnabotulinumtoxinA on Intramural Parasympathetic Ganglia: An Experimental Study in the Guinea Pig Bladder

2012 ◽  
Vol 187 (3) ◽  
pp. 1121-1126 ◽  
Author(s):  
Ana Coelho ◽  
Francisco Cruz ◽  
Célia D. Cruz ◽  
António Avelino
Keyword(s):  
Experimental Study ◽  
Guinea Pig ◽  
Parasympathetic Ganglia

Electrophysiological properties of neurons in guinea pig bronchial parasympathetic ganglia

1990 ◽  
Vol 259 (6) ◽  
pp. L403-L409 ◽  
Author(s):  
A. C. Myers ◽  
B. J. Undem ◽  
D. Weinreich
Keyword(s):  
Guinea Pig ◽  
Vagus Nerve ◽  
Action Potentials ◽  
Receptor Activation ◽  
Membrane Properties ◽  
Constant Current ◽  
Parasympathetic Ganglia ◽  
Stimulation Of ◽  
Passive Membrane

Active and passive membrane membrane properties of parasympathetic neurons were examined in vitro in a newly localized ganglion on the right bronchus of the guinea pig. Neurons could be classified as “tonic” or “phasic” based on their action potential discharge response to suprathreshold depolarizing constant current steps. Tonic neurons (39%) responded with repetitive action potentials sustained throughout the current step, whereas phasic neurons (61%) responded with an initial burst of action potentials at the onset of the step but then accommodated. Tonic and phasic neurons could not be differentiated by other active or passive membrane properties. Electrical stimulation of the vagus nerve elicited one to three temporally distinct fast nicotinic excitatory potentials, and tetanic stimulation of the vagus nerve evoked slow depolarizing (10% of neurons) and hyperpolarizing (25% of neurons) potentials; the latter was mimicked by muscarinic receptor activation. Similar slow and fast postsynaptic potentials were observed in both tonic and phasic neurons. We suggest neurons within the bronchial ganglion possess membrane and synaptic properties capable of integrating presynaptic stimuli.

EXPERIMENTAL STUDY OF DIPHTHERITIC POLYNEURITIS IN THE RABBIT AND GUINEA PIG

1960 ◽  
Vol 19 (1) ◽  
pp. 7-24 ◽  
Author(s):  
GUIDO MAJNO ◽  
BYRON H. WAKSMAN ◽  
MANFRED L. KARNOVSKY
Keyword(s):  
Experimental Study ◽  
Guinea Pig
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