Coexisting pulmonary nodules in operable lung cancer: Prevalence and probability of malignancy

IntroductionThe utilisation of chest CT for the evaluation of pulmonary disorders, including low-dose CT for lung cancer screening, is increasing in the USA. As a result, the discovery of both screening-detected and incidental pulmonary nodules has become more frequent. Despite an overall low risk of malignancy, pulmonary nodules are a common cause of emotional distress among adult patients.MethodsWe conducted a multi-institutional quality improvement (QI) initiative involving 101 participants to determine the effect of a pulmonary nodule fact sheet on patient knowledge and anxiety. Males and females aged 35 years or older, who had a history of either screening-detected or incidental solid pulmonary nodule(s) sized 3–8 mm, were included. Prior to an internal medicine or pulmonary medicine clinic visit, participants were given a packet containing a pre-fact sheet survey, a pulmonary nodule fact sheet and a post-fact sheet survey.ResultsOf 101 patients, 61 (60.4%) worried about their pulmonary nodule at least once per month with 18 (17.8%) worrying daily. The majority 67/101 (66.3%) selected chemotherapy, chemotherapy and radiation, or radiation as the best method to cure early-stage lung cancer. Despite ongoing radiographic surveillance, 16/101 (15.8%) stated they would not be interested in an intervention if lung cancer was diagnosed. Following review of the pulmonary nodule fact sheet, 84/101 (83.2%) reported improved anxiety and 96/101 (95.0%) reported an improved understanding of their health situation. Patient understanding significantly improved from 4.2/10.0 to 8.1/10.0 (p<0.01).ConclusionThe incorporation of a standardised fact sheet for subcentimeter solid pulmonary nodules improves patient understanding and alleviates anxiety. We plan to implement pulmonary nodule fact sheets into the care of our patients with low-risk subcentimeter pulmonary nodules.

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Plasma secretory phospholipase A2-IIa as a potential biomarker for lung cancer in patients with solitary pulmonary nodules

BMC Cancer ◽

10.1186/1471-2407-11-513 ◽

2011 ◽

Vol 11 (1) ◽

Cited By ~ 25

Author(s):

Elena Kupert ◽

Marshall Anderson ◽

Yin Liu ◽

Paul Succop ◽

Linda Levin ◽

...

Keyword(s):

Lung Cancer ◽

Phospholipase A2 ◽

Pulmonary Nodules ◽

Secretory Phospholipase A2 ◽

Solitary Pulmonary Nodules ◽

Secretory Phospholipase ◽

Potential Biomarker

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Effect of Nodule Characteristics on Variability of Semiautomated Volume Measurements in Pulmonary Nodules Detected in a Lung Cancer Screening Program

Radiology ◽

10.1148/radiol.2482070957 ◽

2008 ◽

Vol 248 (2) ◽

pp. 625-631 ◽

Cited By ~ 53

Author(s):

Ying Wang ◽

Rob J. van Klaveren ◽

Hester J. van der Zaag–Loonen ◽

Geertruida H. de Bock ◽

Hester A. Gietema ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Screening ◽

Screening Program ◽

Pulmonary Nodules ◽

Lung Cancer Screening ◽

Cancer Screening Program ◽

Volume Measurements ◽

Lung Cancer Screening Program

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Malignant melanoma without primary, presenting as solitary pulmonary nodule: a case report

Journal of Medical Case Reports ◽

10.1186/s13256-021-02933-z ◽

2021 ◽

Vol 15 (1) ◽

Author(s):

George Tsaknis ◽

Muhammad Naeem ◽

Advitya Singh ◽

Siddharth Vijayakumar

Keyword(s):

Lung Cancer ◽

Malignant Melanoma ◽

Pulmonary Nodule ◽

Solitary Pulmonary Nodule ◽

Past History ◽

White Male ◽

Pulmonary Nodules ◽

Metastatic Malignant Melanoma ◽

Unknown Primary ◽

Solitary Pulmonary Nodules

Abstract Background Solitary pulmonary nodules are the most common incidental finding on chest imaging. Their management is very well defined by several guidelines, with risk calculators for lung cancer being the gold standard. Solitary intramuscular metastasis combined with a solitary pulmonary nodule from malignant melanoma without a primary site is rare. Case presentation A 57-year-old white male was referred to our lung cancer service with solitary pulmonary nodule. After positron-emission tomography, we performed an ultrasound-guided core needle biopsy of an intramuscular solitary lesion, not identified on computed tomography scan, and diagnosed metastatic malignant melanoma. The solitary pulmonary nodule was resected and also confirmed metastatic melanoma. There was no primary skin lesion. The patient received oral targeted therapy and is disease-free 5 years later. Conclusions Clinicians dealing with solitary pulmonary nodules must remain vigilant for other extrathoracic malignancies even in the absence of obvious past history. Lung metastasectomy may have a role in metastatic malignant melanoma with unknown primary.

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Lung adenocarcinoma and sequential antineutrophil cytoplasmic antibody-associated vasculitis: a case report

Journal of International Medical Research ◽

10.1177/0300060521993319 ◽

2021 ◽

Vol 49 (2) ◽

pp. 030006052199331

Author(s):

Chun-Yang Zhang ◽

Ran Miao ◽

Wei Li ◽

Hao-Yong Ning ◽

Xiang-En Meng ◽

...

Keyword(s):

Lung Cancer ◽

Histological Examination ◽

Crescentic Glomerulonephritis ◽

Elevated Serum ◽

Pulmonary Nodules ◽

Antineutrophil Cytoplasmic Antibody ◽

Necrotizing Crescentic Glomerulonephritis ◽

Transthoracic Biopsy ◽

Nasal Inflammation ◽

The Relationship

The relationship between antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and lung cancer remains unclear. A 66-year-old man presented with pulmonary nodules. Histological examination of a specimen from computed tomography-guided percutaneous transthoracic biopsy revealed adenocarcinoma. The patient was treated using cryoablation and systemic chemotherapy. Sixteen months later, the patient presented with fever, nasal inflammation, recurrent lung lesions, elevated serum creatinine levels, and high levels of ANCA. Histological examination of a specimen from ultrasound-guided percutaneous renal biopsy revealed pauci-immune necrotizing crescentic glomerulonephritis. The patient responded to treatment, but granulomatosis with polyangiitis recurred and he later died. This case highlights the possibility of sequential AAV with lung cancer. Although this is relatively rare, further research is needed to better understand the association or pathophysiological link between lung cancer and AAV.

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Cost-Effectiveness of Treatment Thresholds for Subsolid Pulmonary Nodules in CT Lung Cancer Screening

Radiology ◽

10.1148/radiol.2021204418 ◽

2021 ◽

pp. 204418

Author(s):

Mark M. Hammer ◽

Andrew L. Eckel ◽

Lauren L. Palazzo ◽

Chung Yin Kong

Keyword(s):

Lung Cancer ◽

Cost Effectiveness ◽

Cancer Screening ◽

Pulmonary Nodules ◽

Lung Cancer Screening ◽

Treatment Thresholds

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After All, It was Not Lung Cancer: When The Evidence is Misleading

European Journal of Case Reports in Internal Medicine ◽

10.12890/2020_002422 ◽

2021 ◽

Author(s):

Joana Braga ◽

Francesca Pereira ◽

Cristiana Fernandes ◽

Marinha Silva ◽

Cristina Marques ◽

...

Keyword(s):

Lung Cancer ◽

Clinical Presentation ◽

Pulmonary Nodules ◽

Rapid Diagnosis ◽

Emission Tomography ◽

Pleuritic Chest Pain ◽

Surgical Specimen ◽

Positron Emission ◽

Malignant Lesions ◽

Serious Disease

The aetiology of pulmonary nodules is varied, with malignant lesions being the most important and requiring rapid diagnosis and treatment. However, although clinical presentation and imaging may suggest a specific diagnosis, it should be kept in mind that some benign pathologies mimic more serious disease. A 50-year-old man presented with left pleuritic chest pain. A CT scan showed an ipsilateral pulmonary spiculated nodule. Pneumonia was assumed and the patient was started on antibiotic therapy. In the absence of improvement, positron emission tomography and a transthoracic aspiration biopsy were performed. Lung cancer was diagnosed and the patient underwent an upper lobectomy. However, examination of the surgical specimen showed no malignancy.

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Meta-analysis of associations between cooking oil fumes exposure and lung cancer risk

Indoor and Built Environment ◽

10.1177/1420326x211030678 ◽

2021 ◽

pp. 1420326X2110306

Author(s):

Xiaofang Zhang ◽

Lei Rao ◽

Qinghong Liu ◽

Qin Yang

Keyword(s):

Lung Cancer ◽

Lung Cancer Risk ◽

Meta Analysis ◽

Cooking Methods ◽

Contributing Factors ◽

Cancer Prevalence ◽

Cooking Oil ◽

Cooking Oil Fumes ◽

The Times ◽

Pan Frying

Lung cancer is one of the most common cancers and cooking oil fumes (COF) are considered as the potential dangerous contributing factors. This study, a meta-analysis was conducted to analyse the correlation between exposure to COF and risk of lung cancer. Literature from 1980 to 2020 were searched and 29 studies were selected for analysis. Results showed that population exposed to COF had significant differences in lung cancer prevalence (P < 0.05). The odds ratio (OR) values of different periods (before 2000, 2000–2010 and 2010–2020) were significantly different. Using ventilation equipment had the OR of 0.54. Liao cuisine, Fujian cuisine, Shanghai cuisine, Jingdong cuisine and Shaanxi cuisine had the ORs (95% confidence interval) of 1.91 (1.62, 2.25), 2.38 (1.80, 3.16), 1.56 (1.29, 1.89), 2.58 (1.63, 4.09) and 1.57 (1.16, 2.11), respectively. These results revealed that exposure to COF could increase the risk of lung cancer, but the risk was gradually reduced with the changes of the times and the use of ventilation equipment. Different cooking methods in different regions caused different risks of lung cancer. The risk of lung cancer caused by COF mainly produced by deep-frying, quick-frying, stir-frying and pan-frying is higher than in other methods.

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