scholarly journals Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function

2021 ◽  
Author(s):  
Vaishali N. Patel ◽  
Dallas L. Pineda ◽  
Elsa Berenstein ◽  
Belinda R. Hauser ◽  
Sophie Choi ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Heparan Sulfate ◽  
Epithelial Morphogenesis ◽  
Salivary Gland Function ◽  
Gland Function

scholarly journals Disease-Induced Changes in Salivary Gland Function and the Composition of Saliva

2021 ◽  
pp. 002203452110048
Author(s):  
G.B. Proctor ◽  
A.M. Shaalan
Keyword(s):  
Salivary Gland ◽  
Sjögren Syndrome ◽  
Healthy Population ◽  
Sjogren Syndrome ◽  
Salivary Gland Function ◽  
Salivary Gland Dysfunction ◽  
Gland Function ◽  
And Function ◽  
The Impact ◽  
Saliva Composition

Although the physiological control of salivary secretion has been well studied, the impact of disease on salivary gland function and how this changes the composition and function of saliva is less well understood and is considered in this review. Secretion of saliva is dependent upon nerve-mediated stimuli, which activate glandular fluid and protein secretory mechanisms. The volume of saliva secreted by salivary glands depends upon the frequency and intensity of nerve-mediated stimuli, which increase dramatically with food intake and are subject to facilitatory or inhibitory influences within the central nervous system. Longer-term changes in saliva secretion have been found to occur in response to dietary change and aging, and these physiological influences can alter the composition and function of saliva in the mouth. Salivary gland dysfunction is associated with different diseases, including Sjögren syndrome, sialadenitis, and iatrogenic disease, due to radiotherapy and medications and is usually reported as a loss of secretory volume, which can range in severity. Defining salivary gland dysfunction by measuring salivary flow rates can be difficult since these vary widely in the healthy population. However, saliva can be sampled noninvasively and repeatedly, which facilitates longitudinal studies of subjects, providing a clearer picture of altered function. The application of omics technologies has revealed changes in saliva composition in many systemic diseases, offering disease biomarkers, but these compositional changes may not be related to salivary gland dysfunction. In Sjögren syndrome, there appears to be a change in the rheology of saliva due to altered mucin glycosylation. Analysis of glandular saliva in diseases or therapeutic interventions causing salivary gland inflammation frequently shows increased electrolyte concentrations and increased presence of innate immune proteins, most notably lactoferrin. Altering nerve-mediated signaling of salivary gland secretion contributes to medication-induced dysfunction and may also contribute to altered saliva composition in neurodegenerative disease.

Neurobiology and Hormonal Control of Lacrimal and Salivary Gland Function

2011 ◽  
pp. 151-175 ◽  
Author(s):  
Yrjö T. Konttinen ◽  
Alberto Vivó Porcar ◽  
Pauliina Porola ◽  
Katja Koskenpato ◽  
María Lorés Rodriguez ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Hormonal Control ◽  
Salivary Gland Function ◽  
Gland Function

Effects of surgical ovariectomy on rat salivary gland function

1993 ◽  
Vol 38 (9) ◽  
pp. 779-784 ◽  
Author(s):  
Karnam R. Purushotham ◽  
Pao-Li Wang ◽  
Calogero Dolce ◽  
Tivadar Zelles ◽  
Josef Blazsek ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Function ◽  
Gland Function ◽  
Rat Salivary Gland

The effect of propranolol on salivary gland function and dental caries development in young and aged rats

1993 ◽  
Vol 38 (10) ◽  
pp. 853-861 ◽  
Author(s):  
A.C. O'Connell ◽  
B.C. Van Wuyckhuyse ◽  
S.K. Pearson ◽  
W.H. Bowen
Keyword(s):  
Salivary Gland ◽  
Dental Caries ◽  
Aged Rats ◽  
Salivary Gland Function ◽  
Gland Function

Mathematical evaluation of post-radiotherapy salivary gland function using salivary gland scintigraphy

2021 ◽  
Author(s):  
Tomohiro Itonaga ◽  
Koichi Tokuuye ◽  
Ryuji Mikami ◽  
Akira Shimizu ◽  
Hiroki Sato ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Conformal Radiotherapy ◽  
Head And Neck Carcinoma ◽  
Salivary Gland Function ◽  
Salivary Gland Scintigraphy ◽  
Radiotherapy Group ◽  
Tolerance Dose ◽  
Gland Function ◽  
Mathematical Evaluation

Objective: Xerostomia is the most common treatment-related toxicity after radiotherapy (RT) for head and neck carcinoma, reducing the quality of life of patients due to a decrease in salivary gland function. Methods: Salivary gland scintigraphy was performed to quantitatively evaluate the salivary gland functions in patients undergoing RT. It was done chronologically for 62 salivary glands of 31 patients before RT and retested 12 months later. Results: The salivary gland functions of most patients deteriorated post-RT and recovered when the radiation dose to the salivary gland was not high. The mean dose to the salivary gland was found to be the most reliable factor in deteriorating salivary gland function, and the tolerance dose was determined to be 46 Gy. The recovery rate of salivary gland function after 1 year of RT was 72% in the RT alone group (n = 10), 56% in the conformal radiotherapy group (n = 15), and 44% in the bioradiotherapy group (n = 6). Conclusion: Scintigraphy revealed that the salivary glands recovered from post-RT hypofunction when decreased doses were administered. The determined tolerance dose of 46 Gy may guide the approach to minimizing associated xerostomia in RT. Advances in knowledge: In this study, the average tolerated dose to the salivary glands was 46 Gy.

scholarly journals Can We Rescue Salivary Gland Function after Irradiation?

2008 ◽  
Vol 8 ◽  
pp. 959-962 ◽  
Author(s):  
Jielin Feng ◽  
Robert P. Coppes
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Function ◽  
Gland Function
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