Improvement of the anti-Candida activity of itraconazole in the zebrafish infection model by its coordination to silver(I)

2021 ◽  
Vol 1232 ◽  
pp. 130006
Author(s):  
Nevena Lj Stevanović ◽  
Biljana Đ. Glišić ◽  
Sandra Vojnovic ◽  
Hubert Wadepohl ◽  
Tina P. Andrejević ◽  
...  
Keyword(s):  
Infection Model ◽  
Zebrafish Infection

scholarly journals Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection

2018 ◽  
Author(s):  
Matt D. Johansen ◽  
Joshua A. Kasparian ◽  
Elinor Hortle ◽  
Warwick J. Britton ◽  
Auriol C. Purdie ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Lipid Metabolism ◽  
Foam Cell ◽  
Mycobacterial Infection ◽  
Foam Cells ◽  
Mycobacterium Marinum ◽  
Infection Model ◽  
Structural Components ◽  
Important Target ◽  
Zebrafish Infection

AbstractHost lipid metabolism is an important target for subversion by pathogenic mycobacteria such as Mycobacterium tuberculosis. The appearance of foam cells within the granuloma are well-characterised effects of chronic tuberculosis. The zebrafish-Mycobacterium marinum infection model recapitulates many aspects of human-M. tuberculosis infection and is used as a model to investigate the structural components of the mycobacterial granuloma. Here, we demonstrate that the zebrafish-M. marinum granuloma contains foam cells and that the transdifferentiation of macrophages into foam cells is driven by the mycobacterial ESX1 pathogenicity locus. This report demonstrates conservation of an important aspect of mycobacterial infection across species.

Development of a Larval Zebrafish Infection Model for Clostridioides difficile

10.3791/60793 ◽  
2020 ◽  
Author(s):  
Junkai Li ◽  
Can M. Ünal ◽  
Kazuhiko Namikawa ◽  
Michael Steinert ◽  
Reinhard W. Köster
Keyword(s):  
Infection Model ◽  
Larval Zebrafish ◽  
Clostridioides Difficile ◽  
Zebrafish Infection

scholarly journals Bioactive Molecule from Streptomyces sp. Mitigates MDR Klebsiella pneumoniae in Zebrafish Infection Model

2017 ◽  
Vol 8 ◽  
Author(s):  
Lalitha Cheepurupalli ◽  
Thiagarajan Raman ◽  
Sudarshan S. Rathore ◽  
Jayapradha Ramakrishnan
Keyword(s):  
Klebsiella Pneumoniae ◽  
Infection Model ◽  
Streptomyces Sp ◽  
Bioactive Molecule ◽  
Zebrafish Infection

Salmonella plasmid virulence gene spvB enhances bacterial virulence by inhibiting autophagy in a zebrafish infection model

2016 ◽  
Vol 49 ◽  
pp. 252-259 ◽  
Author(s):  
Yuan-yuan Li ◽  
Ting Wang ◽  
Song Gao ◽  
Guang-mei Xu ◽  
Hua Niu ◽  
...  
Keyword(s):  
Virulence Gene ◽  
Bacterial Virulence ◽  
Infection Model ◽  
Zebrafish Infection

Dithiazole thione derivative as competitive NorA efflux pump inhibitor to curtail multi drug resistant clinical isolate of MRSA in a zebrafish infection model

2016 ◽  
Vol 100 (21) ◽  
pp. 9265-9281 ◽  
Author(s):  
Rene Christena Lowrence ◽  
Thiagarajan Raman ◽  
Himesh V. Makala ◽  
Venkatasubramanian Ulaganathan ◽  
Selva Ganesan Subramaniapillai ◽  
...  
Keyword(s):  
Clinical Isolate ◽  
Efflux Pump ◽  
Infection Model ◽  
Drug Resistant ◽  
Efflux Pump Inhibitor ◽  
Zebrafish Infection

scholarly journals A preliminary study of in vitro and in vivo synergistic effects of ciprofloxacin and D-tyrosine against Pseudomonas aeruginosa isolates

2020 ◽  
Vol 19 (8) ◽  
pp. 1731-1736
Author(s):  
Huirong Li ◽  
Wei Jiang ◽  
Xiaoshuang He ◽  
Mengting Chen
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Synergistic Effects ◽  
Multidrug Resistant ◽  
Clinical Isolates ◽  
Infection Model ◽  
Antimicrobial Effects ◽  
Kill Curve ◽  
Zebrafish Infection

Purpose: To investigate the synergistic antimicrobial effects of ciprofloxacin and D-tyrosine against drug-resistant bacteria.Method: The antimicrobial effects of ciprofloxacin and D-tyrosine on clinical isolates of multidrugresistant (MDR) Pseudomonas aeruginosa (P. aeruginosa) no. 3556 were determined in vitro based on time-kill curve, and in vivo in P. aeruginosa-zebrafish infection model. Furthermore, 30 clinical isolates of multidrug-resistant P. aeruginosa were used in vitro to ascertain the synergistic effect of the two agents.Results: Combined use of ciprofloxacin and D-tyrosine produced synergistic effects against the clinical isolate of P. aeruginosa no. 3556 in vitro and in vivo. Synergism occurred in 96.67 % (95 % CI, range 83.33 - 99.41 %) of the clinical isolates, and ciprofloxacin dose was reduced in 90 % (95 % CI, range 74.38 - 96.54 %) of the clinical isolates in vitro.Conclusion: These preliminary results suggest that the combination of ciprofloxacin and D-tyrosine is a promising therapeutic strategy against MDR P. aeruginosa infections. Keywords: Ciprofloxacin, D-tyrosine, Synergistic, P. aeruginosa, Zebrafish infection model, Time-killing curve

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