Gadolinium deposition in the brain

2016 ◽  
Vol 34 (10) ◽  
pp. 1346-1350 ◽  
Author(s):  
Tomonori Kanda ◽  
Yudai Nakai ◽  
Hiroshi Oba ◽  
Keiko Toyoda ◽  
Kazuhiro Kitajima ◽  
...  
Keyword(s):  
Gadolinium Deposition ◽  
The Brain

Gadolinium deposition in the brain: Lessons learned from other metals known to cross the blood–brain barrier

2016 ◽  
Vol 34 (10) ◽  
pp. 1366-1372 ◽  
Author(s):  
John P. Prybylski ◽  
Erin Maxwell ◽  
Carla Coste Sanchez ◽  
Michael Jay
Keyword(s):  
Blood Brain Barrier ◽  
Lessons Learned ◽  
Brain Barrier ◽  
Gadolinium Deposition ◽  
Blood Brain ◽  
The Brain

Gadolinium deposition in the brain: summary of evidence and recommendations

2017 ◽  
Vol 16 (7) ◽  
pp. 564-570 ◽  
Author(s):  
Vikas Gulani ◽  
Fernando Calamante ◽  
Frank G Shellock ◽  
Emanuel Kanal ◽  
Scott B Reeder
Keyword(s):  
Gadolinium Deposition ◽  
The Brain

scholarly journals Gadolinium Deposition in the Brain: A Systematic Review of Existing Guidelines and Policy Statement Issued by the Canadian Association of Radiologists

2018 ◽  
Vol 69 (4) ◽  
pp. 373-382 ◽  
Author(s):  
Andreu F. Costa ◽  
Christian B. van der Pol ◽  
Pejman Jabehdar Maralani ◽  
Matthew D.F. McInnes ◽  
Jason R. Shewchuk ◽  
...  
Keyword(s):  
Systematic Review ◽  
Working Group ◽  
Conclusive Evidence ◽  
Severe Allergic Reaction ◽  
Policy Statement ◽  
Hepatobiliary Phase ◽  
Phase Imaging ◽  
Gadolinium Deposition ◽  
Canadian Association ◽  
The Brain

Emerging evidence has confirmed that, following administration of a gadolinium-based contrast agent (GBCA), very small amounts of gadolinium will deposit in the brain of humans with intact blood-brain barriers. The literature is evolving rapidly and the degree to which gadolinium will deposit for a particular GBCA or class of GBCAs remains undetermined. Several studies suggest that linear GBCAs deposit more gadolinium in the brain compared with macrocyclic GBCAs; however, our understanding of the molecular composition of deposited gadolinium is preliminary, and the clinical significance of gadolinium deposition remains unknown. To date, there is no conclusive evidence linking gadolinium deposition in the brain with any adverse patient outcome. A panel of radiologists representing the Canadian Association of Radiologists was assembled to assist the Canadian medical imaging community in making informed decisions regarding the issue of gadolinium deposition in the brain. The objectives of the working group were: 1) to review the evidence from animal and human studies; 2) to systematically review existing guidelines and position statements issued by other organizations and health agencies; and 3) to formulate an evidence-based position statement on behalf of the Canadian Association of Radiologists. Based on our appraisal of the evidence and systematic review of 9 guidelines issued by other organizations, the working group established the following consensus statement. GBCA administration should be considered carefully with respect to potential risks and benefits, and only used when required. Standard dosing should be used and repeat administrations should be avoided unless necessary. Gadolinium deposition is one of several issues to consider when prescribing a particular GBCA. Currently there is insufficient evidence to recommend one class of GBCA over another. The panel considered it inappropriate to withhold a linear GBCA if a macrocyclic agent is unavailable, if hepatobiliary phase imaging is required, or if there is a history of severe allergic reaction to a macrocyclic GBCA. Further study in this area is required, and the evidence should be monitored regularly with policy statements updated accordingly.

Evaluation of Gadolinium Deposition in the Brain After MR Arthrography

2018 ◽  
Vol 211 (5) ◽  
pp. 1063-1067 ◽  
Author(s):  
Stephen F. Kralik ◽  
Krish K. Singhal ◽  
Mark S. Frank ◽  
Lauren M. Ladd
Keyword(s):  
Mr Arthrography ◽  
Gadolinium Deposition ◽  
The Brain

scholarly journals Gadolinium Deposition in the Brain: Current Updates

2019 ◽  
Vol 20 (1) ◽  
pp. 134 ◽  
Author(s):  
Jin Woo Choi ◽  
Won-Jin Moon
Keyword(s):  
Gadolinium Deposition ◽  
The Brain

scholarly journals Gadolinium Deposition in the Brain in a Large Animal Model

2019 ◽  
Vol 54 (9) ◽  
pp. 531-536 ◽  
Author(s):  
Alexander Radbruch ◽  
Henning Richter ◽  
Stefanie Fingerhut ◽  
Louise Francoise Martin ◽  
Anna Xia ◽  
...  
Keyword(s):  
Animal Model ◽  
Large Animal Model ◽  
Large Animal ◽  
Gadolinium Deposition ◽  
The Brain

Effects of Gadolinium Deposition in the Brain on Motor or Behavioral Function: A Mouse Model

Radiology ◽  
2021 ◽  
pp. 210892
Author(s):  
Hiroyuki Akai ◽  
Kazuya Miyagawa ◽  
Kohei Takahashi ◽  
Atsumi Mochida-Saito ◽  
Kazuhiro Kurokawa ◽  
...  
Keyword(s):  
Mouse Model ◽  
Behavioral Function ◽  
Gadolinium Deposition ◽  
The Brain
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