Preparation and characterization of aligned porous PCL/zein scaffolds as drug delivery systems via improved unidirectional freeze-drying method

The aim of this study was to optimize the method used for obtaining microparticles based on chitosan � a biocompatible, biodegradable, and nontoxic polymer, and to characterize the developed systems. Chitosan microparticles, as drug delivery systems were obtained by inotropic gelation method using pentasodiumtripolyphosphate (TPP) as cross-linking agent. Chitosan with low molecular weight (CSLMW) in concentration which ranged between 0.5 and 5 %, was used while the concentration of cross-linking agent ranged between 1 and 5%. The characterization of the microparticles in terms of shape, uniformity and adhesion was performed in solution and dried state. The size of the microparticles and the degree of swelling were also determined. The structure and the morphology of the developed polymeric systems were analyzed by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).The average diameter of the chitosan microparticles was around 522 �m. The most stable microparticles were obtained using CSLMW 1% and TPP 2% or CSLMW 0.75%and TPP 1%. The micropaticles were spherical, uniform and without flattening. Using CSLMW in concentration of 0.5 % poorly cross-linked and crushed microparticles have been obtained at all TPP concentrations. By optimization of the method, stable chitosan-based micropaticles were obtained which will be used to develop controlled release systems for drug delivery.

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Formulation and characterization of novel lipid-based drug delivery systems containing polymethacrylate polymers as solid carriers for sustained release of simvastatin

Journal of Drug Delivery Science and Technology ◽

10.1016/j.jddst.2019.101222 ◽

2019 ◽

Vol 53 ◽

pp. 101222 ◽

Cited By ~ 2

Author(s):

Zora Ćetković ◽

Sandra Cvijić ◽

Dragana Vasiljević

Keyword(s):

Drug Delivery ◽

Sustained Release ◽

Drug Delivery Systems ◽

Delivery Systems

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Sensing technologies and experimental platforms for the characterization of advanced oral drug delivery systems

Advanced Drug Delivery Reviews ◽

10.1016/j.addr.2021.113850 ◽

2021 ◽

pp. 113850

Author(s):

Peter Ouma Okeyo ◽

Sriram Thoppe Rajendran ◽

Kinga Zór ◽

Anja Boisen

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Oral Drug Delivery ◽

Delivery Systems ◽

Oral Drug ◽

Oral Drug Delivery Systems

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Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery

Scientia Pharmaceutica ◽

10.3390/scipharm87030020 ◽

2019 ◽

Vol 87 (3) ◽

pp. 20 ◽

Cited By ~ 35

Author(s):

Miléna Lengyel ◽

Nikolett Kállai-Szabó ◽

Vince Antal ◽

András József Laki ◽

István Antal

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Freeze Drying ◽

Delivery Systems ◽

The Novel ◽

Practical Applications ◽

Inhaled Insulin ◽

Formulation Factors ◽

Novel Drug ◽

Significant Production

Microparticles, microspheres, and microcapsules are widely used constituents of multiparticulate drug delivery systems, offering both therapeutic and technological advantages. Microparticles are generally in the 1–1000 µm size range, serve as multiunit drug delivery systems with well-defined physiological and pharmacokinetic benefits in order to improve the effectiveness, tolerability, and patient compliance. This paper reviews their evolution, significance, and formulation factors (excipients and procedures), as well as their most important practical applications (inhaled insulin, liposomal preparations). The article presents the most important structures of microparticles (microspheres, microcapsules, coated pellets, etc.), interpreted with microscopic images too. The most significant production processes (spray drying, extrusion, coacervation, freeze-drying, microfluidics), the drug release mechanisms, and the commonly used excipients, the characterization, and the novel drug delivery systems (microbubbles, microsponges), as well as the preparations used in therapy are discussed in detail.

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