scholarly journals Effects of chronic constriction injury and spared nerve injury, two models of neuropathic pain, on the numbers of neurons and glia in the rostral ventromedial medulla

2016 ◽  
Vol 617 ◽  
pp. 82-87 ◽  
Author(s):  
Mai Lan Leong ◽  
Rebecca Speltz ◽  
Martin Wessendorf
Keyword(s):  
Neuropathic Pain ◽  
Nerve Injury ◽  
Chronic Constriction Injury ◽  
Rostral Ventromedial Medulla ◽  
Spared Nerve Injury ◽  
Ventromedial Medulla

scholarly journals Activation of the Mammalian Target of Rapamycin in the Rostral Ventromedial Medulla Contributes to the Maintenance of Nerve Injury-Induced Neuropathic Pain in Rat

2015 ◽  
Vol 2015 ◽  
pp. 1-16 ◽  
Author(s):  
Jian Wang ◽  
Da-Yun Feng ◽  
Zhi-Hua Li ◽  
Ban Feng ◽  
Han Zhang ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Nerve Injury ◽  
Mtor Inhibitor ◽  
Mammalian Target Of Rapamycin ◽  
Brain Slices ◽  
Rostral Ventromedial Medulla ◽  
Target Of Rapamycin ◽  
Ventromedial Medulla ◽  
Relay Region

The mammalian target of rapamycin (mTOR), a serine-threonine protein kinase, integrates extracellular signals, thereby modulating several physiological and pathological processes, including pain. Previous studies have suggested that rapamycin (an mTOR inhibitor) can attenuate nociceptive behaviors in many pain models, most likely at the spinal cord level. However, the mechanisms of mTOR at the supraspinal level, particularly at the level of the rostral ventromedial medulla (RVM), remain unclear. Thus, the aim of this study was to elucidate the role of mTOR in the RVM, a key relay region for the descending pain control pathway, under neuropathic pain conditions. Phosphorylated mTOR was mainly expressed in serotonergic spinally projecting neurons and was significantly increased in the RVM after spared nerve injury- (SNI-) induced neuropathic pain. Moreover, in SNI rat brain slices, rapamycin infusion both decreased the amplitude instead of the frequency of spontaneous excitatory postsynaptic currents and reduced the numbers of action potentials in serotonergic neurons. Finally, intra-RVM microinjection of rapamycin effectively alleviated established mechanical allodynia but failed to affect the development of neuropathic pain. In conclusion, our data provide strong evidence for the role of mTOR in the RVM in nerve injury-induced neuropathic pain, indicating a novel mechanism of mTOR inhibitor-induced analgesia.

Intrathecal TRESK gene recombinant adenovirus attenuates spared nerve injury-induced neuropathic pain in rats

Neuroreport ◽  
2013 ◽  
Vol 24 (3) ◽  
pp. 131-136 ◽  
Author(s):  
Jun Zhou ◽  
Cheng-Xiang Yang ◽  
Ji-Ying Zhong ◽  
Han-Bing Wang
Keyword(s):  
Neuropathic Pain ◽  
Nerve Injury ◽  
Recombinant Adenovirus ◽  
Spared Nerve Injury ◽  
Gene Recombinant
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