The effect of perinatal exposure to ethinyl oestradiol or a mixture of endocrine disrupting pesticides on kisspeptin neurons in the rat hypothalamus

2013 ◽  
Vol 37 ◽  
pp. 154-162 ◽  
Author(s):  
Agnete Overgaard ◽  
Klaus Holst ◽  
Karen R. Mandrup ◽  
Julie Boberg ◽  
Sofie Christiansen ◽  
...  
Keyword(s):  
Perinatal Exposure ◽  
Rat Hypothalamus ◽  
Endocrine Disrupting ◽  
Ethinyl Oestradiol

Perinatal exposure to mixtures of endocrine disrupting chemicals reduces female rat follicle reserves and accelerates reproductive aging

2016 ◽  
Vol 61 ◽  
pp. 186-194 ◽  
Author(s):  
Hanna Katarina Lilith Johansson ◽  
Pernille Rosenskjold Jacobsen ◽  
Ulla Hass ◽  
Terje Svingen ◽  
Anne Marie Vinggaard ◽  
...  
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Perinatal Exposure ◽  
Reproductive Aging ◽  
Female Rat ◽  
Endocrine Disrupting

scholarly journals Perinatal Exposure to Phthalates: From Endocrine to Neurodevelopment Effects

2021 ◽  
Vol 22 (8) ◽  
pp. 4063
Author(s):  
Laura Lucaccioni ◽  
Viola Trevisani ◽  
Erica Passini ◽  
Beatrice Righi ◽  
Carlotta Plessi ◽  
...  
Keyword(s):  
System Development ◽  
Endocrine Disrupting Chemicals ◽  
Cognitive Disorders ◽  
Perinatal Exposure ◽  
Adverse Health Outcomes ◽  
Endocrine Disrupting ◽  
And Function ◽  
The Impact ◽  
Temporal Windows

Phthalates, as other endocrine disrupting chemicals (EDCs), may alter the homeostasis and the action of hormones and signaling molecules, causing adverse health outcomes. This is true especially for infants, who are both more exposed and sensitive to their effects. Phthalates are particularly harmful when the exposure occurs during certain critical temporal windows of the development, such as the prenatal and the early postnatal phases. Phthalates may also interfere with the neuroendocrine systems (e.g., thyroid hormone signaling or metabolism), causing disruption of neuronal differentiation and maturation, increasing the risk of behavioral and cognitive disorders (ADHD and autistic behaviors, reduced mental, psychomotor, and IQ development, and emotional problems). Despite more studies being needed to better understand the role of these substances, plenty of evidence suggests the impact of phthalates on the neuroendocrine system development and function. This review aims to update the knowledge on the neuroendocrine consequences of neonatal and perinatal exposure to phthalates.

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