scholarly journals Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex

Neuron ◽  
2020 ◽  
Vol 108 (6) ◽  
pp. 1113-1129.e6
Author(s):  
Lei Xing ◽  
Nereo Kalebic ◽  
Takashi Namba ◽  
Samir Vaid ◽  
Pauline Wimberger ◽  
...  
Keyword(s):  
Serotonin Receptor ◽  
Basal Progenitor ◽  
Serotonin Receptor 2A ◽  
Developing Neocortex

SAFETY OF THERAPY WITH ANTIPSYCHOTICS: THE SEROTONIN RECEPTOR 2A (HTR2A) GENE AND METABOLIC DISORDERS

Vrach ◽  
2019 ◽  
Vol 30 (1) ◽  
Author(s):  
L. Akhmetova ◽  
M. Tolmachev ◽  
N. Shnaider ◽  
T. Potupchik ◽  
E. Ershov ◽  
...  
Keyword(s):  
Serotonin Receptor ◽  
Metabolic Disorders ◽  
Serotonin Receptor 2A ◽  
Htr2a Gene

The interaction between serotonin receptor 2A and catechol-O-methyltransferase gene polymorphisms is associated with the novelty-seeking subscale impulsiveness

2010 ◽  
Vol 20 (6) ◽  
pp. 273-281 ◽  
Author(s):  
Johanna Salo ◽  
Laura Pulkki-Råback ◽  
Mirka Hintsanen ◽  
Terho Lehtimäki ◽  
Liisa Keltikangas-Järvinen
Keyword(s):  
Gene Polymorphisms ◽  
Serotonin Receptor ◽  
Novelty Seeking ◽  
Serotonin Receptor 2A ◽  
Methyltransferase Gene

scholarly journals Stress exposure and psychopathology alter methylation of the serotonin receptor 2A (HTR2A) gene in preschoolers

2017 ◽  
Vol 29 (5) ◽  
pp. 1619-1626 ◽  
Author(s):  
Stephanie H. Parade ◽  
Andrew M. Novick ◽  
Justin Parent ◽  
Ronald Seifer ◽  
Samantha J. Klaver ◽  
...  
Keyword(s):  
Child Protection ◽  
Life Stress ◽  
Serotonin Receptor ◽  
Stress Reactivity ◽  
Psychiatric Symptoms ◽  
Stress Exposure ◽  
Negatively Associated ◽  
Cpg Sites ◽  
Serotonin System ◽  
Serotonin Receptor 2A

AbstractSerotonin signaling pathways play a key role in brain development, stress reactivity, and mental health. Epigenetic alterations in the serotonin system may underlie the effect of early life stress on psychopathology. The current study examined methylation of the serotonin receptor 2A (HTR2A) gene in a sample of 228 children including 119 with child welfare documentation of moderate to severe maltreatment within the last 6 months. Child protection records, semistructured interviews in the home, and parent reports were used to assess child stress exposure, psychiatric symptoms, and behavior. The HTR2A genotype and methylation of HTR2A were measured at two CpG sites (–1420 and –1224) from saliva DNA. HTR2A genotype was associated with HTR2A methylation at both CpG sites. HTR2A genotype also moderated associations of contextual stress exposure and HTR2A methylation at site –1420. Contextual stress was positively associated with –1420 methylation among A homozygotes, but negatively associated with –1420 methylation among G homozygotes. Posttraumatic stress disorder and major depressive disorder symptoms were negatively associated with methylation at –1420, but positively associated with methylation at –1224. Results support the view that the serotonin system is sensitive to stress exposure and psychopathology, and HTR2A methylation may be a mechanism by which early adversity is biologically encoded.

Serotonin receptor 2A, 2C, 1A genes and response to lithium prophylaxis in mood disorders

2000 ◽  
Vol 34 (2) ◽  
pp. 89-98 ◽  
Author(s):  
Alessandro Serretti ◽  
Cristina Lorenzi ◽  
Roberta Lilli ◽  
Enrico Smeraldi
Keyword(s):  
Mood Disorders ◽  
Serotonin Receptor ◽  
Serotonin Receptor 2A

scholarly journals Polymorphisms of Serotonin Receptor 2A and 2C Genes and COMT in Relation to Obesity and Type 2 Diabetes

PLoS ONE ◽  
2009 ◽  
Vol 4 (8) ◽  
pp. e6696 ◽  
Author(s):  
Sofia I. I. Kring ◽  
Thomas Werge ◽  
Claus Holst ◽  
Søren Toubro ◽  
Arne Astrup ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Serotonin Receptor ◽  
Serotonin Receptor 2A

scholarly journals Polyomavirus JC infects human brain microvascular endothelial cells independent of serotonin receptor 2A

Virology ◽  
2007 ◽  
Vol 364 (1) ◽  
pp. 55-63 ◽  
Author(s):  
Moti L. Chapagain ◽  
Saguna Verma ◽  
Frederic Mercier ◽  
Richard Yanagihara ◽  
Vivek R. Nerurkar
Keyword(s):  
Endothelial Cells ◽  
Human Brain ◽  
Serotonin Receptor ◽  
Microvascular Endothelial Cells ◽  
Brain Microvascular Endothelial Cells ◽  
Polyomavirus Jc ◽  
Serotonin Receptor 2A ◽  
Microvascular Endothelial
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