Delta-opioid receptor antagonism leads to excessive ethanol consumption in mice with enhanced activity of the endogenous opioid system

2017 ◽  
Vol 118 ◽  
pp. 90-101 ◽  
Author(s):  
Piotr Poznanski ◽  
Anna Lesniak ◽  
Michal Korostynski ◽  
Klaudia Szklarczyk ◽  
Marzena Lazarczyk ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Ethanol Consumption ◽  
Opioid System ◽  
Delta Opioid Receptor ◽  
Endogenous Opioid System ◽  
Endogenous Opioid ◽  
Receptor Antagonism ◽  
Enhanced Activity

Interleukin-6 is differently modulated by central opioid receptor subtypes

1997 ◽  
Vol 273 (3) ◽  
pp. R956-R959 ◽  
Author(s):  
M. Bertolucci ◽  
C. Perego ◽  
M. G. De Simoni
Keyword(s):  
Opioid Receptor ◽  
Fine Tuning ◽  
Opioid System ◽  
Receptor Subtypes ◽  
Receptor Blockade ◽  
Endogenous Opioid System ◽  
Endogenous Opioid ◽  
General Role ◽  
Opioid Receptor Subtypes ◽  
Mu Antagonist

The central endogenous opioid system is involved in the modulation of interleukin (IL)-6, an inflammatory cytokine that plays a major role in the acute phase response. The present study evaluates whether specific opioid receptor subtypes are selectively involved in this immunomodulatory action. IL-1 beta was administered either intracerebroventricularly or intraperitoneally at the dose of 400 ng to rats pretreated with the mu-antagonist beta-funaltrexamine, the delta-antagonist naltrindole, or the kappa-antagonist nor-binaltorphimine, each at the doses of 1, 10, and 100 micrograms/rat intracerebroventricularly. Serum IL-6 levels were measured 2 h later. The results show that mu-receptor blockade increases, whereas delta-receptor blockade decreases IL-6 induction, suggesting that the fine tuning exerted by opioids on the immune system may be achieved through a balance of opposing effects. Moreover the three antagonists affect IL-6 induction by central and peripheral IL-1 beta with a similar pattern, indicating that the brain endogenous opioid system plays a general role in the regulation of this cytokine.

scholarly journals The Influence of Cross-Fostering on Alcohol Consumption and Depressive-Like Behaviors in HA and LA Mice: The Role of the Endogenous Opioid System

2021 ◽  
Vol 11 (5) ◽  
pp. 622
Author(s):  
Agata Nawrocka ◽  
Piotr Poznański ◽  
Marzena Łazarczyk ◽  
Michał Gorzałczyński ◽  
Dominik Skiba ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Ethanol Consumption ◽  
Ethanol Intake ◽  
Opioid System ◽  
Endogenous Opioid System ◽  
Endogenous Opioid ◽  
Surrogate Mothers ◽  
Biological Parents ◽  
Genetic And Environmental Factors ◽  
Cross Fostering

The development of alcohol dependence and depression is determined by various genetic and environmental factors. In the presented study, we used high analgesia (HA) and low analgesia (LA) mouse lines, characterized by different endogenous opioid system activity and divergent blood–brain barrier permeability, to determine the influence of cross-fostering of these lines raised by surrogate mothers on ethanol consumption and development of depressive-like behaviors. We also investigated ethanol drinking by biological parents or surrogate mothers. Furthermore, we investigated whether these parental changes would alter the effect of naloxone on ethanol intake and depressive-like behaviors in offspring. Our results reveal that cross-fostering of HA and LA raised by surrogate mothers has a greater impact on depressive-like behaviors than ethanol consumption. Ethanol intake by biological parents substantially affected depressive-like behaviors and ethanol consumption in offspring. Moreover, ethanol intake by biological parents or an adoptive mother modified the effect of naloxone on ethanol consumption and preference and depressive-like behaviors in the HA offspring only. Together, these results indicate that cross-fostering differentially affects the effect of naloxone on alcohol consumption and the development of depression.

Implication of the endogenous opioid system in excessive ethanol consumption

Alcohol ◽  
1996 ◽  
Vol 13 (1) ◽  
pp. 19-23 ◽  
Author(s):  
Christina Gianoulakis ◽  
Jean-Pascal de Waele ◽  
Joseph Thavundayil
Keyword(s):  
Ethanol Consumption ◽  
Opioid System ◽  
Endogenous Opioid System ◽  
Endogenous Opioid

scholarly journals Interplay between the Endogenous Opioid System and Proteasome Complex: Beyond Signaling

2019 ◽  
Vol 20 (6) ◽  
pp. 1441 ◽  
Author(s):  
Francesca Caputi ◽  
Laura Rullo ◽  
Serena Stamatakos ◽  
Sanzio Candeletti ◽  
Patrizia Romualdi
Keyword(s):  
Opioid Receptor ◽  
Stress Responses ◽  
Intracellular Signaling ◽  
Proteasome Inhibitors ◽  
Receptor Activation ◽  
Opioid System ◽  
Post Translational Modification ◽  
Endogenous Opioid System ◽  
Self Administration ◽  
Endogenous Opioid

Intracellular signaling mechanisms underlying the opioid system regulation of nociception, neurotransmitters release, stress responses, depression, and the modulation of reward circuitry have been investigated from different points of view. The presence of the ubiquitin proteasome system (UPS) in the synaptic terminations suggest a potential role of ubiquitin-dependent mechanisms in the control of the membrane occupancy by G protein-coupled receptors (GPCRs), including those belonging to the opioid family. In this review, we focused our attention on the role played by the ubiquitination processes and by UPS in the modulation of opioid receptor signaling and in pathological conditions involving the endogenous opioid system. The collective evidence here reported highlights the potential usefulness of proteasome inhibitors in neuropathic pain, addictive behavior, and analgesia since these molecules can reduce pain behavioral signs, heroin self-administration, and the development of morphine analgesic tolerance. Moreover, the complex mechanisms involved in the effects induced by opioid agonists binding to their receptors include the ubiquitination process as a post-translational modification which plays a relevant role in receptor trafficking and degradation. Hence, UPS modulation may offer novel opportunities to control the balance between therapeutic versus adverse effects evoked by opioid receptor activation, thus, representing a promising druggable target.

MODULATION BY CCK-B RECEPTORS OF THE ANTINOCICEPTIVE AND REWARDING PROPERTIES INDUCED BY THE ENDOGENOUS OPIOID SYSTEM

Analgesia ◽  
1995 ◽  
Vol 1 (4) ◽  
pp. 809-812
Author(s):  
O. Valverde ◽  
M.-C. Fournié-Zaluski ◽  
B. P. Roques ◽  
R. Maldonado
Keyword(s):  
Opioid System ◽  
Endogenous Opioid System ◽  
Endogenous Opioid

scholarly journals Nicotine Effects and the Endogenous Opioid System

2014 ◽  
Vol 125 (2) ◽  
pp. 117-124 ◽  
Author(s):  
Shiroh Kishioka ◽  
Norikazu Kiguchi ◽  
Yuka Kobayashi ◽  
Fumihiro Saika
Keyword(s):  
Opioid System ◽  
Endogenous Opioid System ◽  
Endogenous Opioid

The Roles of Endogenous Opioid System in the Antidepressant Actions of Ketamine

2021 ◽  
Vol 89 (9) ◽  
pp. S385
Author(s):  
Cheng Jiang ◽  
Ralph DiLeone ◽  
Christopher Pittenger ◽  
Ronald Duman
Keyword(s):  
Opioid System ◽  
Endogenous Opioid System ◽  
Endogenous Opioid

Role of the endogenous opioid system in the analgesic effect of ?-tocopherol in dysmenorrhea

1988 ◽  
Vol 105 (2) ◽  
pp. 162-164 ◽  
Author(s):  
G. N. Kryzhanovskii ◽  
L. P. Bakuleva ◽  
N. L. Luzina ◽  
V. A. Vinogradov ◽  
K. N. Yarygin ◽  
...  
Keyword(s):  
Analgesic Effect ◽  
Opioid System ◽  
Endogenous Opioid System ◽  
Endogenous Opioid
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