Cyclin-dependent kinase 5 activator p35 over-expression and amyloid beta synergism increase apoptosis in cultured neuronal cells

Neuroscience ◽  
2009 ◽  
Vol 161 (4) ◽  
pp. 978-987 ◽  
Author(s):  
E. Utreras ◽  
R. Maccioni ◽  
C. González-Billault
Keyword(s):  
Amyloid Beta ◽  
Neuronal Cells ◽  
Cyclin Dependent Kinase ◽  
Over Expression ◽  
Cyclin Dependent Kinase 5

scholarly journals Inhibition of cyclin-dependent kinase 5 affects early neuroinflammatory signalling in murine model of amyloid beta toxicity

2018 ◽  
Vol 15 (1) ◽  
Author(s):  
Anna Wilkaniec ◽  
Magdalena Gąssowska-Dobrowolska ◽  
Marcin Strawski ◽  
Agata Adamczyk ◽  
Grzegorz A. Czapski
Keyword(s):  
Amyloid Beta ◽  
Murine Model ◽  
Cyclin Dependent Kinase ◽  
Cyclin Dependent Kinase 5

scholarly journals p25/Cyclin-Dependent Kinase 5 Induces Production and Intraneuronal Accumulation of Amyloid beta In Vivo

2006 ◽  
Vol 26 (41) ◽  
pp. 10536-10541 ◽  
Author(s):  
J. C. Cruz ◽  
D. Kim ◽  
L. Y. Moy ◽  
M. M. Dobbin ◽  
X. Sun ◽  
...  
Keyword(s):  
Amyloid Beta ◽  
Cyclin Dependent Kinase ◽  
Cyclin Dependent Kinase 5

scholarly journals Cyclin-Dependent Kinase 5 Differentially Regulates the Transcriptional Activity of the Glucocorticoid Receptor through Phosphorylation: Clinical Implications for the Nervous System Response to Glucocorticoids and Stress

2007 ◽  
Vol 21 (7) ◽  
pp. 1552-1568 ◽  
Author(s):  
Tomoshige Kino ◽  
Takamasa Ichijo ◽  
Niranjana D. Amin ◽  
Sashi Kesavapany ◽  
Yonghong Wang ◽  
...  
Keyword(s):  
Nervous System ◽  
Glucocorticoid Receptor ◽  
Transcriptional Activity ◽  
Biological Activities ◽  
Neuronal Cells ◽  
System Response ◽  
Cyclin Dependent Kinase ◽  
Proteolytic Fragment ◽  
End Effectors ◽  
Cyclin Dependent Kinase 5

Abstract Glucocorticoids, major end effectors of the stress response, play an essential role in the homeostasis of the central nervous system and influence diverse functions of neuronal cells. We found that cyclin-dependent kinase 5 (CDK5), which plays important roles in the morphogenesis and functions of the nervous system and whose aberrant activation is associated with development of neurodegenerative disorders, interacted with the ligand-binding domain of the glucocorticoid receptor (GR) through its activator p35 or its active proteolytic fragment p25. CDK5 phosphorylated GR at multiple serines, including Ser203 and Ser211 of its N-terminal domain, and suppressed the transcriptional activity of this receptor on glucocorticoid-responsive promoters by attenuating attraction of transcriptional cofactors to DNA. In microarray analyses using rat cortical neuronal cells, the CDK5 inhibitor roscovitine differentially regulated the transcriptional activity of the GR on more than 90% of the endogenous glucocorticoid-responsive genes tested. Thus, CDK5 exerts some of its biological activities in neuronal cells through the GR, dynamically modulating GR transcriptional activity in a target promoter-dependent fashion.

The role of Cyclin Dependent Kinase 5 in mechanism of amyloid beta toxicity. Significance in Alzheimer’s disease

2011 ◽  
Vol 63 (5) ◽  
pp. 1270-1271
Author(s):  
A. Czapski Grzegorz ◽  
Gąssowska Magdalena ◽  
Songin Martyna ◽  
B. Strosznajder Joanna
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Cyclin Dependent Kinase ◽  
Cyclin Dependent Kinase 5

Hypoxic preconditioning reduces expression of the cyclin dependent kinase 5 in the post-ischemic neurons

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S309-S309
Author(s):  
Svetlana Pundik ◽  
W David Lust ◽  
Jose Valerio ◽  
Michael Buczek ◽  
Randall D York ◽  
...  
Keyword(s):  
Hypoxic Preconditioning ◽  
Cyclin Dependent Kinase ◽  
Cyclin Dependent Kinase 5

Homology Modeling of Mus Musculus CDK5 and Molecular Docking Studies with Flavonoids

2017 ◽  
Vol 9 (6) ◽  
Author(s):  
Sowmya Suri ◽  
Rumana Waseem ◽  
Seshagiri Bandi ◽  
Sania Shaik
Keyword(s):  
Molecular Docking ◽  
3D Model ◽  
Structural Features ◽  
Docking Studies ◽  
Amino Acid Residues ◽  
Cyclin Dependent Kinase ◽  
Ligand Complex ◽  
Ligand Interaction ◽  
Molecular Docking Studies ◽  
Cyclin Dependent Kinase 5

A 3D model of Cyclin-dependent kinase 5 (CDK5) (Accession Number: Q543f6) is generated based on crystal structure of P. falciparum PFPK5-indirubin-5-sulphonate ligand complex (PDB ID: 1V0O) at 2.30 Å resolution was used as template. Protein-ligand interaction studies were performed with flavonoids to explore structural features and binding mechanism of flavonoids as CDK5 (Cyclin-dependent kinase 5) inhibitors. The modelled structure was selected on the basis of least modeler objective function. The model was validated by PROCHECK. The predicted 3D model is reliable with 93.0% of amino acid residues in core region of the Ramachandran plot. Molecular docking studies with flavonoids viz., Diosmetin, Eriodictyol, Fortuneletin, Apigenin, Ayanin, Baicalein, Chrysoeriol and Chrysosplenol-D with modelled protein indicate that Diosmetin is the best inhibitor containing docking score of -8.23 kcal/mol. Cys83, Lys89, Asp84. The compound Diosmetin shows interactions with Cys83, Lys89, and Asp84.

Sign in / Sign up

Export Citation Format

Share Document