scholarly journals Chronic stress alters neural activity in medial prefrontal cortex during retrieval of extinction

Neuroscience ◽  
2011 ◽  
Vol 174 ◽  
pp. 115-131 ◽  
Author(s):  
A.A. Wilber ◽  
A.G. Walker ◽  
C.J. Southwood ◽  
M.R. Farrell ◽  
G.L. Lin ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Chronic Stress ◽  
Medial Prefrontal Cortex ◽  
Neural Activity

scholarly journals Molecular mechanism of reward treatment ameliorating chronic stress-induced depressive-like behavior assessed by sequencing miRNA and mRNA in medial prefrontal cortex

2020 ◽  
Author(s):  
Tingting An ◽  
Zhenhua Song ◽  
Jin-Hui Wang
Keyword(s):  
Major Depressive Disorder ◽  
Prefrontal Cortex ◽  
Depressive Disorder ◽  
Molecular Mechanism ◽  
Chronic Stress ◽  
Medial Prefrontal Cortex ◽  
Differentially Expressed ◽  
Mild Stress ◽  
Major Depressive ◽  
Differentially Expressed Mirnas

Abstract Background Major depressive disorder (MDD) is a disease that seriously endangers human health and mental state. Chronic stress and lack of reward may reduce the function of the brain's reward circuits, leading to major depressive disorder. The effect of reward treatment on chronic stress-induced depression-like behaviors and its molecular mechanism in the brain remain unclear.Methods Mice were divided into the groups of control, chronic unpredictable mild stress (CUMS), and CUMS-companion. Mice of CUMS group was performed by CUMS for 4 weeks, and CUMS-companion group was treated by CUMS accompanied with companion. The tests of sucrose preference, Y-maze, and forced swimming were conducted to assess depression-like behaviors or resilience. High-throughput sequencing was used to analyze mRNA and miRNA profiles in the medial prefrontal cortex harvested from control, CUMS-MDD (mice with depression-like behaviors in CUMS group), Reward-MDD (mice with depression-like behaviors in CUMS-companion group), CUMS-resilience (resilient mice in CUMS group), Reward-resilience (resilient mice in CUMS-companion group) mice.Results The results provided evidence that accompanying with companion ameliorated CUMS-induced depression-like behaviors in mice. 45 differentially expressed genes (DEGs) are associated with depression-like behaviors, 8 DEGs are associated with resilience and 59 DEGs are associated with nature reward (companion) were identified. Furthermore, 196 differentially expressed miRNAs were found to be associated with companion. Based on the differentially expressed miRNAs and DEGs data, miRNA-mRNA network was established to be associated with companion.Conclusion Taken together, our data here provided a method to ameliorate depression-like behaviors, and numerous potential drug targets for the prevention or treatment of depression.

scholarly journals The Rat Medial Prefrontal Cortex Exhibits Flexible Neural Activity States during the Performance of an Odor Span Task

eNeuro ◽  
2019 ◽  
Vol 6 (2) ◽  
pp. ENEURO.0424-18.2019 ◽  
Author(s):  
Emanuela De Falco ◽  
Lei An ◽  
Ninglei Sun ◽  
Andrew J. Roebuck ◽  
Quentin Greba ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Neural Activity ◽  
Span Task ◽  
Odor Span

Sensitization of norepinephrine release in medial prefrontal cortex: effect of different chronic stress protocols

1999 ◽  
Vol 830 (2) ◽  
pp. 211-217 ◽  
Author(s):  
Hank P. Jedema ◽  
Alan F. Sved ◽  
Michael J. Zigmond ◽  
Janet M. Finlay
Keyword(s):  
Prefrontal Cortex ◽  
Chronic Stress ◽  
Medial Prefrontal Cortex ◽  
Norepinephrine Release

Chronic stress alters inhibitory networks in the medial prefrontal cortex of adult mice

2012 ◽  
Vol 218 (6) ◽  
pp. 1591-1605 ◽  
Author(s):  
Javier Gilabert-Juan ◽  
Esther Castillo-Gomez ◽  
Ramón Guirado ◽  
Maria Dolores Moltó ◽  
Juan Nacher
Keyword(s):  
Prefrontal Cortex ◽  
Chronic Stress ◽  
Medial Prefrontal Cortex ◽  
Adult Mice ◽  
Inhibitory Networks

scholarly journals A comparison of neural responses in the primary auditory cortex, amygdala, and medial prefrontal cortex of cats during auditory discrimination tasks

2019 ◽  
Vol 121 (3) ◽  
pp. 785-798 ◽  
Author(s):  
Zhenling Zhao ◽  
Lanlan Ma ◽  
Yifei Wang ◽  
Ling Qin
Keyword(s):  
Prefrontal Cortex ◽  
Auditory Cortex ◽  
Medial Prefrontal Cortex ◽  
Neural Activity ◽  
Primary Auditory Cortex ◽  
Temporal Patterns ◽  
Auditory Discrimination ◽  
Neural Representation ◽  
Behavioral Choice ◽  
Behavioral Choices

Discriminating biologically relevant sounds is crucial for survival. The neurophysiological mechanisms that mediate this process must register both the reward significance and the physical parameters of acoustic stimuli. Previous experiments have revealed that the primary function of the auditory cortex (AC) is to provide a neural representation of the acoustic parameters of sound stimuli. However, how the brain associates acoustic signals with reward remains unresolved. The amygdala (AMY) and medial prefrontal cortex (mPFC) play keys role in emotion and learning, but it is unknown whether AMY and mPFC neurons are involved in sound discrimination or how the roles of AMY and mPFC neurons differ from those of AC neurons. To examine this, we recorded neural activity in the primary auditory cortex (A1), AMY, and mPFC of cats while they performed a Go/No-go task to discriminate sounds with different temporal patterns. We found that the activity of A1 neurons faithfully coded the temporal patterns of sound stimuli; this activity was not affected by the cats’ behavioral choices. The neural representation of stimulus patterns decreased in the AMY, but the neural activity increased when the cats were preparing to discriminate the sound stimuli and waiting for reward. Neural activity in the mPFC did not represent sound patterns, but it showed a clear association with reward and was modulated by the cats’ behavioral choices. Our results indicate that the initial auditory representation in A1 is gradually transformed into a stimulus–reward association in the AMY and mPFC to ultimately generate a behavioral choice. NEW & NOTEWORTHY We compared the characteristics of neural activities of primary auditory cortex (A1), amygdala (AMY), and medial prefrontal cortex (mPFC) while cats were performing the same auditory discrimination task. Our results show that there is a gradual transformation of the neural code from a faithful temporal representation of the stimulus in A1, which is insensitive to behavioral choices, to an association with the predictive reward in AMY and mPFC, which, to some extent, is correlated with the animal’s behavioral choice.

Sign in / Sign up

Export Citation Format

Share Document