Non-alcoholic fatty liver disease is associated with left ventricular diastolic dysfunction in essential hypertension

2009 ◽  
Vol 19 (9) ◽  
pp. 646-653 ◽  
Author(s):  
F. Fallo ◽  
A. Dalla Pozza ◽  
N. Sonino ◽  
M. Lupia ◽  
F. Tona ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Liver Disease ◽  
Fatty Liver ◽  
Diastolic Dysfunction ◽  
Fatty Liver Disease ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Alcoholic Fatty Liver ◽  
Ventricular Diastolic Dysfunction ◽  
Alcoholic Fatty Liver Disease

scholarly journals Non-alcoholic fatty liver disease and left ventricular diastolic dysfunction in patients with metabolic syndrome

2020 ◽  
Vol 183 (11) ◽  
pp. 25-33
Author(s):  
S. N. Jadhav ◽  
V. G. Radchenko
Keyword(s):  
Metabolic Syndrome ◽  
Liver Disease ◽  
Diastolic Dysfunction ◽  
Liver Damage ◽  
Fatty Liver Disease ◽  
Left Ventricular Diastolic Dysfunction ◽  
Left Ventricular ◽  
Alcoholic Fatty Liver ◽  
Ventricular Diastolic Dysfunction ◽  
Alcoholic Fatty Liver Disease

The purpose of the study was to determine the frequency and nature of manifestations of left ventricular diastolic dysfunction in patients with non-alcoholic fatty liver disease with the background of metabolic syndrome (MS).Characteristics of patients and research methods: To solve this problem, 227 patients with MS (130 men and 97 women) were examined. The study was conducted in two phases. At the first stage, all patients with MS are divided into two groups: patients with NAFLD — 205 people and 22 — without liver damage. At the next stage, a group of NAFLD patients with left ventricular DD (n=136) (66.34%) (the main group) and patients with no DD (n=69) (33.66%) (the comparison group) were identified.Results of the study: the results of diagnostics, clinical and laboratory manifestations of left ventricular diastolic dysfunction in 136 patients with NAFLD on the background of metabolic syndrome are Presented. Significant factors of development and progression of diastolic dysfunction were identified, which include increased body weight and adipose tissue, insulin resistance, dyslipidemia, hyperuricemia, activity and stage of liver damage. According to the data of structural and functional changes in the myocardium, the role of diastolic dysfunction in the development of chronic heart failure in patients with NAFLD with manifestations of metabolic syndrome has been established.Conclusion: it was Found that the development of left ventricular diastolic dysfunction in patients with NAFLD is due to the morphofunctional state of the liver.

scholarly journals Non-alcoholic fatty liver disease is associated with early left ventricular dysfunction in childhood acute lymphoblastic leukaemia survivors

2017 ◽  
Vol 176 (2) ◽  
pp. 111-121 ◽  
Author(s):  
Maurizio Delvecchio ◽  
Paola Muggeo ◽  
Mariantonietta Monteduro ◽  
Giuseppe Lassandro ◽  
Chiara Novielli ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Alcoholic Fatty Liver ◽  
Childhood All ◽  
Ventricular Ejection Fraction ◽  
Childhood Acute Lymphoblastic Leukaemia ◽  
Alcoholic Fatty Liver Disease

Background Childhood acute lymphoblastic leukaemia (ALL) survivors have an increased risk of metabolic and cardiovascular disease. We aimed to assess the presence of non-alcoholic fatty liver disease (NAFLD) in childhood ALL and if it is associated with early cardiovascular dysfunction. Methods In total, 53 childhood ALL survivors and 34 controls underwent auxological evaluation, biochemical assay, liver, heart and vascular ultrasound study. Results NAFLD was more frequent in ALL patients than in controls (39.6% vs 11.7%, P < 0.01). Patients with NAFLD were more obese and insulin resistant than patients without NAFLD. Flow-mediated dilatation and interventricular septum were lower in the ALL group than those in the control group (P < 0.001 for both). The patients with NAFLD showed lower left ventricular ejection fraction than those without NAFLD (P = 0.011). In ALL survivors, BMI-SDS and subcutaneous fat were the strongest predictors of NAFLD, whereas preperitoneal adipose tissue and C-reactive protein were the strongest predictors of left ventricular ejection fraction. Conclusions Childhood ALL survivors had higher prevalence of NAFLD than healthy controls, which is associated with early left ventricular impairment. In the case of fatty liver, a comprehensive heart evaluation is mandatory. We strongly recommend to prevent visceral adiposity in ALL survivors, to search for metabolic syndrome or its components and to reinforce the need of intervention on diet and lifestyle during the follow-up of these patients.

Sign in / Sign up

Export Citation Format

Share Document