P9. The impact of neoadjuvant chemotherapy on operable locally advanced squamous cell carcinoma of the buccal mucosa

Oral Oncology ◽  
2011 ◽  
Vol 47 ◽  
pp. S77
Author(s):  
R. Kumar ◽  
S.V. Shah ◽  
V.L. Choksi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Neoadjuvant Chemotherapy ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Buccal Mucosa ◽  
Locally Advanced ◽  
Advanced Squamous Cell Carcinoma ◽  
The Impact

scholarly journals Role of high dose rate interstitial brachytherapy in early and locally advanced squamous cell carcinoma of buccal mucosa

SpringerPlus ◽  
2014 ◽  
Vol 3 (1) ◽  
Author(s):  
Parthasarathy Vedasoundaram ◽  
Aravind Kumar Prasanna ◽  
Reddy KS ◽  
Gangothri Selvarajan ◽  
Mourougan Sinnatamby ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Dose Rate ◽  
Squamous Cell ◽  
Buccal Mucosa ◽  
Locally Advanced ◽  
High Dose Rate ◽  
High Dose ◽  
Advanced Squamous Cell Carcinoma

Tailoring the Treatment of Locally Advanced Squamous Cell Carcinoma of the Vulva: Neoadjuvant Chemotherapy Followed by Radical Surgery

2012 ◽  
Vol 22 (7) ◽  
pp. 1258-1263 ◽  
Author(s):  
Alejandro M. Aragona ◽  
Nicasio Cuneo ◽  
Alejandro H. Soderini ◽  
Elsa Alcoba ◽  
Adriana Greco ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Neoadjuvant Chemotherapy ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Radical Surgery ◽  
Locally Advanced ◽  
Multicenter Trial ◽  
Response To Treatment ◽  
Advanced Squamous Cell Carcinoma ◽  
Treatment Type

ObjectiveTo determine the feasibility of performing neoadjuvant chemotherapy (NCH) followed by radical surgery in patients with locally advanced squamous cell carcinoma of the vulva.MethodsProspective and multicenter trial. Thirty-five patients with a diagnosis of previously untreated locally advanced squamous cell carcinoma of the vulva were given 4 schemes of cisplatin-based NCH and 1 NCH regimen with single bleomycin. Then, they underwent radical surgery of the vulva if clinical response was 50% or more. Age, NCH schemes used, toxicity, response to treatment, type of radical surgery performed, and clinical outcome were evaluated.ResultsThirty-three patients completed the proposed schemes, and 30 were assessed for radical surgery. Finally, 27 patients underwent radical surgery (radical vulvectomy or radical local excision plus bilateral inguinofemoral lymphadenectomy). In 2 cases of persistent rectal involvement, posterior pelvic exenteration was performed. Moreover, 24 of 27 patients remain with no evidence of disease to date. Toxicity was acceptable. Median age was 62 years (range, 54–72 years). Median follow-up was 49 months (range, 4–155 months).ConclusionsThe use of NCH in selected groups may increase surgical feasibility in initially inoperable patients, thus favoring organ preservation and less extensive resections. Adverse reactions were acceptable, and vulvoperineal deleterious effects that may occur after radiotherapy were consequently avoided.

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