Natural History of Thoracic Aortic Aneurysms: Size Matters, Plus Moving Beyond Size

2013 ◽  
Vol 56 (1) ◽  
pp. 74-80 ◽  
Author(s):  
Katherine H. Chau ◽  
John A. Elefteriades
Keyword(s):  
Natural History ◽  
Aortic Aneurysms ◽  
Thoracic Aortic Aneurysms ◽  
History Of

scholarly journals Natural history of thoracic aortic aneurysms

2012 ◽  
Vol 56 (2) ◽  
pp. 565-571 ◽  
Author(s):  
Gregory A. Kuzmik ◽  
Adam X. Sang ◽  
John A. Elefteriades
Keyword(s):  
Natural History ◽  
Aortic Aneurysms ◽  
Thoracic Aortic Aneurysms ◽  
History Of

Prospective Study of the Natural History of Thoracic Aortic Aneurysms

1997 ◽  
Vol 63 (6) ◽  
pp. 1533-1545 ◽  
Author(s):  
Tatu Juvonen ◽  
M.Arisan Ergin ◽  
Jan D Galla ◽  
Steven L Lansman ◽  
Khanh H Nguyen ◽  
...  
Keyword(s):  
Natural History ◽  
Prospective Study ◽  
Aortic Aneurysms ◽  
Thoracic Aortic Aneurysms ◽  
History Of

Natural History of Arteriosclerotic Thoracic Aortic Aneurysms

1978 ◽  
Vol 26 (5) ◽  
pp. 468-473 ◽  
Author(s):  
J. Judson McNamara ◽  
Virginia M. Pressler
Keyword(s):  
Natural History ◽  
Aortic Aneurysms ◽  
Thoracic Aortic Aneurysms ◽  
History Of

scholarly journals The natural history of thoracic aortic aneurysms

1994 ◽  
Vol 107 (5) ◽  
pp. 1323-1333 ◽  
Author(s):  
Otto E. Dapunt ◽  
Jan D. Galla ◽  
Ali M. Sadeghi ◽  
Steven L. Lansman ◽  
Craig K. Mezrow ◽  
...  
Keyword(s):  
Natural History ◽  
Aortic Aneurysms ◽  
Thoracic Aortic Aneurysms ◽  
History Of

A Population-Based Study of the Incidence and Natural History of Degenerative Thoracic Aortic Aneurysms

2021 ◽  
Author(s):  
Ying Huang ◽  
Hartzell V. Schaff ◽  
Joseph A. Dearani ◽  
Gustavo S. Oderich ◽  
Thomas C. Bower ◽  
...  
Keyword(s):  
Natural History ◽  
Population Based ◽  
Aortic Aneurysms ◽  
Population Based Study ◽  
Thoracic Aortic Aneurysms ◽  
History Of

Effects of long-term chloroquine administration on the natural history of aortic aneurysms in mice

2015 ◽  
Vol 93 (8) ◽  
pp. 641-648 ◽  
Author(s):  
Azza Ramadan ◽  
Mark D. Wheatcroft ◽  
Adrian Quan ◽  
Krishna K. Singh ◽  
Fina Lovren ◽  
...  
Keyword(s):  
Natural History ◽  
Thrombus Formation ◽  
Aortic Aneurysms ◽  
Ang Ii ◽  
Abdominal Aortic ◽  
Suprarenal Aorta ◽  
History Of ◽  
Categorical Distribution

Autophagy regulates cellular homeostasis and integrates the cellular pro-survival machinery. We investigated the role of autophagy in the natural history of murine abdominal aortic aneurysms (AAA). ApoE−/− mice were implanted with saline- or angiotensin II (Ang-II)-filled miniosmotic pumps then treated with either the autophagy inhibitor chloroquine (CQ; 50 mg·(kg body mass)–1·day–1, by intraperitoneal injection) or saline. Ang-II-elicited aneurysmal expansion of the suprarenal aorta coupled with thrombus formation were apparent 8 weeks later. CQ had no impact on the incidence (50% for Ang-II compared with 46.2% for Ang-II + CQ; P = NS) and categorical distribution of aneurysms. The markedly reduced survival rate observed with Ang-II (57.1% for Ang-II compared with 100% for saline; P < 0.05) was unaffected by CQ (61.5% for Ang-II + CQ; P = NS compared with Ang-II). CQ did not affect the mean maximum suprarenal aortic diameter (1.91 ± 0.19 mm for Ang-II compared with 1.97 ± 0.21 mm for Ang-II + CQ; P = NS). Elastin fragmentation, collagen accumulation, and smooth muscle attrition, which were higher in Ang-II-treated mice, were unaffected by CQ treatment. Long-term CQ administration does not affect the natural history and prognosis of experimental AAA, suggesting that global loss of autophagy is unlikely to be a causal factor in the development of aortic aneurysms. Manipulation of autophagy as a mechanism to reduce AAA may need re-evaluation.

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