Influence of combinations of digitonin with selected phenolics, terpenoids, and alkaloids on the expression and activity of P-glycoprotein in leukaemia and colon cancer cells

Phytomedicine ◽  
2013 ◽  
Vol 21 (1) ◽  
pp. 47-61 ◽  
Author(s):  
Safaa Yehia Eid ◽  
Mahmoud Zaki El-Readi ◽  
Essam Eldin Mohamed Nour Eldin ◽  
Sameer Hassan Fatani ◽  
Michael Wink
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
P Glycoprotein ◽  
Expression And Activity

miRNA-29a reverses P-glycoprotein-mediated drug resistance and inhibits proliferation via up-regulation of PTEN in colon cancer cells

2020 ◽  
Vol 880 ◽  
pp. 173138 ◽  
Author(s):  
Xiaoxin Shi ◽  
Amir Valizadeh ◽  
Seyed Mostafa Mir ◽  
Zatollah Asemi ◽  
Ansar Karimian ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
P Glycoprotein

scholarly journals EPS8 Facilitates Cellular Growth and Motility of Colon Cancer Cells by Increasing the Expression and Activity of Focal Adhesion Kinase

2007 ◽  
Vol 282 (27) ◽  
pp. 19399-19409 ◽  
Author(s):  
Ming-Chei Maa ◽  
Jenq-Chang Lee ◽  
Yen-Jen Chen ◽  
Yun-Ju Chen ◽  
Yuch-Ching Lee ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Focal Adhesion Kinase ◽  
Cancer Cells ◽  
Focal Adhesion ◽  
Cellular Growth ◽  
Colon Cancer Cells ◽  
Expression And Activity

scholarly journals HIF-1α Inhibition Reverses Multidrug Resistance in Colon Cancer Cells via Downregulation of MDR1/P-Glycoprotein

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e98882 ◽  
Author(s):  
Jianfang Chen ◽  
Zhenyu Ding ◽  
Yonghai Peng ◽  
Feng Pan ◽  
Jianjun Li ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
P Glycoprotein

scholarly journals The Combined Use of Phenothiazines and Statins Strongly Affects Doxorubicin-Resistance, Apoptosis, and Cox-2 Activity in Colon Cancer Cells

2019 ◽  
Vol 20 (4) ◽  
pp. 955 ◽  
Author(s):  
Kamila Środa-Pomianek ◽  
Krystyna Michalak ◽  
Anna Palko-Łabuz ◽  
Anna Uryga ◽  
Piotr Świątek ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Caspase 3 ◽  
Colon Cancer Cells ◽  
Phenothiazine Derivatives ◽  
Component Mixture ◽  
P Glycoprotein ◽  
Novel Approach ◽  
Combined Use ◽  
Cox 2

Since none of the multidrug resistance (MDR) modulators tested so far found their way into clinic, a novel approach to overcome the MDR of cancer cells has been proposed. The combined use of two MDR modulators of dissimilar mechanisms of action was suggested to benefit from the synergy between them. The effect of three phenothiazine derivatives that were used as single agents and in combination with simvastatin on cell growth, apoptosis induction, activity, and expression of cyclooxygenase-2 (COX-2) in doxorubicin-resistant colon cancer cells (LoVo/Dx) was investigated. Treatment of LoVo/Dx cells by phenothiazine derivatives combined with simvastatin resulted in an increase of doxorubicin cytotoxicity and its intracellular accumulation as compared to the treatment with phenothiazine derivatives that were used as single agents. Similarly, LoVo/Dx cells treated with two-component mixture of modulators showed the reduced expression of ABCB1 (P-glycoprotein) transporter and COX-2 enzyme, both on mRNA and protein level. Reduced expression of anti-apoptotic Bcl-2 protein and increased expression of pro-apoptotic Bax were also detected. Additionally, COX-2 activity was diminished, and caspase-3 activity was increased to a higher extent by phenothiazine derivative:simvastatin mixtures than by phenothiazine derivatives themselves. Therefore, the introduction of simvastatin strengthened the anti-MDR, anti-inflammatory, and pro-apoptotic properties of phenothiazines in LoVo/Dx cells.

scholarly journals Nitric oxide and P-glycoprotein modulate the phagocytosis of colon cancer cells

2011 ◽  
Vol 15 (7) ◽  
pp. 1492-1504 ◽  
Author(s):  
Joanna Kopecka ◽  
Ivana Campia ◽  
Davide Brusa ◽  
Sophie Doublier ◽  
Lina Matera ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
P Glycoprotein
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