scholarly journals Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study

2015 ◽  
Vol 102-103 ◽  
pp. 13-20 ◽  
Author(s):  
Alison J. Yeates ◽  
Tanzy M. Love ◽  
Karin Engström ◽  
Maria S. Mulhern ◽  
Emeir M. McSorley ◽  
...  
2012 ◽  
Vol 97 (1) ◽  
pp. 45-57 ◽  
Author(s):  
Liandré F van der Merwe ◽  
Sophie E Moore ◽  
Anthony J Fulford ◽  
Katherine E Halliday ◽  
Saikou Drammeh ◽  
...  

2020 ◽  
Vol 94 ◽  
Author(s):  
D. Babaran ◽  
M.T. Arts ◽  
R.J. Botelho ◽  
S.A. Locke ◽  
J. Koprivnikar

Abstract The free-living infectious stages of macroparasites, specifically, the cercariae of trematodes (flatworms), are likely to be significant (albeit underappreciated) vectors of nutritionally important polyunsaturated fatty acids (PUFA) to consumers within aquatic food webs, and other macroparasites could serve similar roles. In the context of de novo omega-3 (n-3) PUFA biosynthesis, it was thought that most animals lack the fatty acid (FA) desaturase enzymes that convert stearic acid (18:0) into ɑ-linolenic acid (ALA; 18:3n-3), the main FA precursor for n-3 long-chain PUFA. Recently, novel sequences of these enzymes were recovered from 80 species from six invertebrate phyla, with experimental confirmation of gene function in five phyla. Given this wide distribution, and the unusual attributes of flatworm genomes, we conducted an additional search for genes for de novo n-3 PUFA in the phylum Platyhelminthes. Searches with experimentally confirmed sequences from Rotifera recovered nine relevant FA desaturase sequences from eight species in four genera in the two exclusively endoparasite classes (Trematoda and Cestoda). These results could indicate adaptations of these particular parasite species, or may reflect the uneven taxonomic coverage of sequence databases. Although additional genomic data and, particularly, experimental study of gene functionality are important future validation steps, our results indicate endoparasitic platyhelminths may have enzymes for de novo n-3 PUFA biosynthesis, thereby contributing to global PUFA production, but also representing a potential target for clinical antihelmintic applications.


2019 ◽  
Vol 63 (15) ◽  
pp. 1801058 ◽  
Author(s):  
Aruna Gorusupudi ◽  
Fu‐Yen Chang ◽  
Kelly Nelson ◽  
Gregory S. Hageman ◽  
Paul S. Bernstein

Lipids ◽  
2002 ◽  
Vol 37 (10) ◽  
pp. 975-980 ◽  
Author(s):  
Laura Amate ◽  
Angel Gil ◽  
María Ramírez

2004 ◽  
Vol 134 (4) ◽  
pp. 868-873 ◽  
Author(s):  
Aleix Sala-Vila ◽  
Ana I. Castellote ◽  
Cristina Campoy ◽  
Montserrat Rivero ◽  
María Rodriguez-Palmero ◽  
...  

2014 ◽  
Vol 144 (9) ◽  
pp. 1430-1437 ◽  
Author(s):  
Carolina Moltó-Puigmartí ◽  
Martien C. J. M. van Dongen ◽  
Pieter C. Dagnelie ◽  
Jogchum Plat ◽  
Ronald P. Mensink ◽  
...  

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