Health-related quality of life among adolescents: A comparison between subjects at ultra-high risk for psychosis and healthy controls

Abstract Background The high risk of cardiovascular disease (CVD) being associated with impaired Health-related quality of life (HRQoL). However, few studies have assessed the HRQoL of individuals with a high risk of CVD in Inner Mongolia, or even in China. We aimed to assess health-related quality of life (HRQoL) among individuals in Inner Mongolia with a high risk of CVD and its risk factors, to provide a reference to improve HRQoL in individuals with high CVD risk. Methods From 2015 to 2017, residents of six villages or communities in Inner Mongolia, selected using a multi-stage stratified cluster random sampling method, were invited to complete a questionnaire and undergo physical examination and laboratory testing. We selected participants whose predicted 10-year risk for CVD exceeded 10% as those with high CVD risk. HRQoL in individuals with high CVD risk was investigated based on the EuroQol-5 Dimension (EQ-5D) scale. The Chinese utility value integral system was used to calculate EQ-5D utility scores, and the Tobit regression model were used to analyze the influencing factors of HRQoL among individuals with high CVD risk. Results Of 13,359 participants with high CVD risk, 65.63% reported no problems in any of the five dimensions; the most frequently reported difficulty was pain/discomfort. The mean utility score was 1.000 (0.869, 1.000). Tobit regression analysis showed that sex, age, education level, residence area, household income, physical activity, hypertension, and dyslipidemia were influencing factors of HRQoL. Conclusion We found that female sex, older age, living in an urban area, lower education level, lower household income, and lower physical activity levels were associated with reduced HRQoL. People with a high risk of CVD should maintain their blood glucose and lipid levels within the normal range.

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Health-Related Quality of Life in Chinese Patients with Chronic Liver Disease

Gastroenterology Research and Practice ◽

10.1155/2012/516140 ◽

2012 ◽

Vol 2012 ◽

pp. 1-7 ◽

Cited By ~ 6

Author(s):

Ru Gao ◽

Feng Gao ◽

Guang Li ◽

Jian Yu Hao

Keyword(s):

Quality Of Life ◽

Prothrombin Time ◽

Chinese Patients ◽

Healthy Controls ◽

Health Related Quality ◽

Severity Of Disease ◽

Health Area ◽

Related Quality ◽

Health Related

Aim. To investigate the factors contributing to health-related quality of life (HRQOL) in Chinese patients with chronic liver disease (CLD).Methods. HRQOL was measured with SF-36v2 Chinese version. Demographic and clinical data were collected, and patients with liver cirrhosis were divided into Child’s Class A, B, and C according to Child-Turcotte-Pugh scoring system.Results. A total of 392 Chinese patients with CLD and 91 healthy controls were enrolled. HRQOL in patients with CLD was lower than that in healthy controls. Score of PCS in healthy controls was54.6±5.5and in CLD was47.8±8.8(P=0.000). Score of MCS in healthy controls was56.4±8.1and in CLD was51.7±7.4(P=0.000). Increasing severity of CLD from no cirrhosis to advanced cirrhosis was associated with a decrease on all domains of the SF-36 (P<0.05). Stepwise linear regression analysis showed that severity of disease, age, present ascites, present varices, and prothrombin time had significant effect on physical health area. Severity of disease, female, present varices, total bilirubin, prothrombin time, and hemoglobin had significant effect on mental health area.Conclusions. Patients with CLD had impaired HRQOL. Increasing severity of CLD was associated with a decrease on HRQOL. Old age, female gender, advanced stage of CLD, present ascites, hyperbilirubinemia, and prolonging prothrombin time were important factors reducing HRQOL.

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Health-related quality of life outcomes in pediatric patients with cardiac rhythm devices: a cross-sectional study with case-control comparison

Health and Quality of Life Outcomes ◽

10.1186/s12955-019-1219-5 ◽

2019 ◽

Vol 17 (1) ◽

Cited By ~ 3

Author(s):

Helene Werner ◽

Phaedra Lehmann ◽

Alina Rüegg ◽

Silvia Hilfiker ◽

Karin Steinmann ◽

...

Keyword(s):

Quality Of Life ◽

Physical Health ◽

Pediatric Patients ◽

Healthy Controls ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Cardiac Medication ◽

Disease Specific

Abstract Background Little is known about health-related quality of life (HRQoL) in pediatric patients with cardiac rhythm devices. This study aims to compare self- and proxy-reported HRQoL in patients with pacemaker (PM) and implantable cardioverter-defibrillator (ICD) to that in sex- and age-matched healthy controls and to examine predictors for generic and disease-specific HRQoL. Methods The study included 72 PM and ICD patients (39% females) and 72 sex- and age-matched healthy controls from 3 to 18 years of age. HRQoL data was obtained by the PedsQL 4.0 Generic Core Scales and Pediatric Cardiac Quality of Life Inventory. Medical data was collected retrospectively from medical records. Results Patients had significantly lower self- and proxy-reported generic overall HRQoL and lower physical health than healthy controls, and ICD patients also had lower psychosocial health. On multivariate analyses, generic overall HRQoL and physical health was significantly predicted by current cardiac medication (β = −.39, p = .02 for overall HRQoL, respectively β = −.44, p = .006 for physical health). Disease-specific overall HRQoL was only marginally predicted by child age, device type, and the presence of a structural congenital heart disease (p < .10). Conclusions This study shows that PM and ICD patients have lower HRQoL than healthy controls and that patients who need cardiac medication are seen by their parents at great risk for lower generic overall HRQoL. Our study also indicates a trend towards higher risk for low disease-specific HRQoL in younger patients, ICD patients, and patients with a structural congenital heart disease. Special attention should be given to these patients as they may benefit from a timely clinical evaluation in order to provide supportive interventions.

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An invited commentary on “Health-Related Quality of Life after Heart Surgery - Identification of high-risk patients: A cohort study” [Int. J. Surg. 76 (2020) 171–177]

International Journal of Surgery ◽

10.1016/j.ijsu.2020.03.054 ◽

2020 ◽

Vol 77 ◽

pp. 130-131

Author(s):

Pradeep Narayan ◽

Suma Chakrabarthi

Keyword(s):

Quality Of Life ◽

Cohort Study ◽

High Risk ◽

Heart Surgery ◽

Health Related Quality ◽

High Risk Patients ◽

Related Quality ◽

Health Related ◽

Risk Patients

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Impact of Bilateral Prophylactic Mastectomy and Immediate Reconstruction on Health-Related Quality of Life in Women at High Risk for Breast Carcinoma: Results of the Mastectomy Reconstruction Outcomes Consortium Study

Annals of Surgical Oncology ◽

10.1245/s10434-017-5915-2 ◽

2017 ◽

Vol 24 (9) ◽

pp. 2502-2508 ◽

Cited By ~ 13

Author(s):

Colleen M. McCarthy ◽

Jennifer B. Hamill ◽

Hyungjin Myra Kim ◽

Ji Qi ◽

Edwin Wilkins ◽

...

Keyword(s):

Quality Of Life ◽

High Risk ◽

Breast Carcinoma ◽

Prophylactic Mastectomy ◽

Health Related Quality ◽

Immediate Reconstruction ◽

Bilateral Prophylactic Mastectomy ◽

Related Quality ◽

Health Related

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Diaphragmatic ultrasound findings correlate with dyspnea, exercise tolerance, health-related quality of life and lung function in patients with fibrotic interstitial lung disease

BMC Pulmonary Medicine ◽

10.1186/s12890-019-0936-1 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 2

Author(s):

Pauliane Vieira Santana ◽

Leticia Zumpano Cardenas ◽

André Luis Pereira de Albuquerque ◽

Carlos Roberto Ribeiro de Carvalho ◽

Pedro Caruso

Keyword(s):

Quality Of Life ◽

Interstitial Lung Disease ◽

Lung Function ◽

Exercise Tolerance ◽

Healthy Controls ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Lower Hrqol

Abstract Background Fibrotic interstitial lung disease (FILD) patients are typically dyspneic and exercise-intolerant with consequent impairment of health-related quality of life (HRQoL). Respiratory muscle dysfunction is among the underlying mechanisms of dyspnea and exercise intolerance in FILD but may be difficult to diagnose. Using ultrasound, we compared diaphragmatic mobility and thickening in FILD cases and healthy controls and correlated these findings with dyspnea, exercise tolerance, HRQoL and lung function. Methods We measured diaphragmatic mobility and thickness during quiet (QB) and deep breathing (DB) and calculated thickening fraction (TF) in 30 FILD cases and 30 healthy controls. We correlated FILD cases’ diaphragmatic findings with dyspnea, exercise tolerance (six-minute walk test), lung function and HRQoL (St. George’s Respiratory Questionnaire). Results Diaphragmatic mobility was similar between groups during QB but was lower in FILD cases during DB when compared to healthy controls (3.99 cm vs 7.02 cm; p < 0.01). FILD cases showed higher diaphragm thickness during QB but TF was lower in FILD when compared to healthy controls (70% vs 188%, p < 0.01). During DB, diaphragmatic mobility and thickness correlated with lung function, exercise tolerance and HRQoL, but inversely correlated with dyspnea. Most FILD cases (70%) presented reduced TF, and these patients had higher dyspnea and exercise desaturation, lower HRQoL and lung function. Conclusion Compared to healthy controls, FILD cases present with lower diaphragmatic mobility and thickening during DB that correlate to increased dyspnea, decreased exercise tolerance, worse HRQoL and worse lung function. FILD cases with reduced diaphragmatic thickening are more dyspneic and exercise-intolerant, have lower HRQoL and lung function.

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