Phthalate levels in urine of pregnant women and their associated missed abortion risk

The study presents data of different authors, as well as its own data on the frequency of multiple trisomies among the early reproductive losses in the I trimester of pregnancy and live fetuses in pregnant women at high risk of chromosomal abnormalities (CA) in I and II trimesters of gestation. The objective: determining the frequency of occurrence of double (DT) and multiple trisomies (MT) among the early reproductive losses in the I trimester of pregnancy and live fetuses in pregnant women at high risk of occurrence of HA in I and II trimesters of gestation; establishment of the most common combinations of diesel fuel and the timing of their deaths compared with single regular trisomy; comparative assessment materinskogo age with single, double and multiple trisomies. Patients and methods. During the period from 1997 to 2016, the first (primary) group of products in 1808 the concept of missed abortion (ST) of I trimester was formed from women who live in Dnepropetrovsk, Zaporozhye, Kirovograd, Cherkasy, Kherson, Mykolaiv regions. The average term of the ST was 8±3 weeks. The average age of women was 29±2 years. The second group (control) consisted of 1572 sample product concepts received during medical abortion in women (mostly residents of Krivoy Rog) in the period of 5-11 weeks of pregnancy, the average age was 32 years. The third group was made prenatally karyotyped fruits (n = 9689) pregnant women with high risk of HA of the above regions of Ukraine, directed the Centre to invasive prenatal diagnosis for individual indications: maternal age, changes in the fetus by ultrasound (characteristic malformations and echo markers HA) and high risk of HA on the results of the combined prenatal screening I and II trimesters. From 11 th to 14 th week of pregnancy, chorionic villus sampling was performed (n=1329), with the 16th week – platsentotsentez (n=2240), 18 th and 24 th week – amniocentesis (n=6120). Results. A comparative evaluation of maternal age and the prevalence anembriony among multiple trisomies. Analyzed 13,069 karyotyped embryonic and fetal I-II trimester of which have found 40 cases of multiple trisomies – 31 cases in the group in 1808 missed abortion (2.84% of total HA), 3 cases including 1 572 induced medabortov and 7 cases during 9689 prenatal research (0.51% of HA). Determined to share the double trisomies preembrionalny, fetal, early, middle and late periods of fetal development. Conclusion. There were no significant differences either in terms of destruction of single and multiple trisomies or in maternal age or in fractions anembrionalnyh pregnancies in these groups. Key words: multiple trisomies, double trisomy, missed abortion, prenatal diagnosis.

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Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio in Missed Abortion

Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics ◽

10.1055/s-0040-1709693 ◽

2020 ◽

Vol 42 (05) ◽

pp. 235-239

Author(s):

Ismail Biyik ◽

Mustafa Albayrak ◽

Fatih Keskin

Keyword(s):

Pregnant Women ◽

Medical Records ◽

Complete Blood Count ◽

Platelet Distribution Width ◽

Platelet Volume ◽

Missed Abortion ◽

Distribution Width ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Inflammatory Parameters

Abstract Objective Missed abortion occurs in ∼ 15% of all clinical pregnancies. The pathogenesis is not clearly known. However, defective placentation resulting in maternal systemic inflammatory response is considered responsible for missed abortion. Platelet lymphocyte ratio (PLR) and neutrophil lymphocyte ratio (NLR) are increasingly cited parameters of inflammation in the literature. However, no study evaluated the PLR and NLR rates in missed abortions so far. The aim of the present study is to investigate whether complete blood count (CBC) inflammatory parameters such as NLR and PLR are increased in patients with missed abortion. Methods Medical records of 40 pregnant women whose gestation ended in missed abortion at between 6 and14 weeks of gestation and of 40 healthy pregnant women were collected and compared retrospectively. The groups were compared regarding hemoglobin, hematocrit, platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), PLR and NLR. Results Platelet distribution width, NLR and PLR values were higher in the missed abortion group compared with the healthy pregnant women group (rates are p = 0.043; p = 0.038; and p = 0.010, respectively). Hematocrit, MPV, and lymphocyte values were found to be lower in the missed abortion group compared with the healthy pregnant women group (p = 0.027, p = 0.044 and p = 0.025, respectively). Conclusion The PDW, NLR and PLR values of the missed abortion group were reported high; and MPV values were reported low in the present study. These findings may help to speculate a defective placentation in the pathogenesis of missed abortion.

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Fetomaternal outcome in COVID-19 infected pregnant women: a preliminary clinical study

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20203843 ◽

2020 ◽

Vol 9 (9) ◽

pp. 3704

Author(s):

Parul T. Shah ◽

Sapana R. Shah ◽

Sushma R. Shah ◽

Pushpa A. Yadava ◽

Babulal S. Patel ◽

...

Keyword(s):

Preterm Birth ◽

Clinical Study ◽

Pregnant Women ◽

Clinical Characteristics ◽

Severe Pneumonia ◽

Third Trimester ◽

Missed Abortion ◽

Viral Nucleic Acid ◽

Live Births ◽

The Third

Background: WHO has declared COVID-19 infection a health emergency of international concern on 11th March, 2020. It is not clear whether clinical characteristics of pregnant women with COVID-19 differ from those of nonpregnant women and whether it aggravates COVID-19 symptoms and whether antiviral therapy is necessary for COVID-19 infected pregnant women.Methods: This is prospective study of 125 cases based on the compiled clinical data for pregnant women with COVID-19 between 15th April 2020 and 10th June 2020. A laboratory confirmed positive case of COVID-19 infection in pregnant women were included.Results: The most common symptoms at presentation were cough in 61.6% (77/125) and fever in 46.4% (58/125). Other reported symptoms were sore throat in 13.6% (17/125), myalgia in 10.4% (13/125) while 38.4% (48/125) were asymptomatic. There were total 97 deliveries (including 2 twins’ deliveries) among which 3 cases had IUD. Present study reported 96 live births. The incidence of missed abortion was 2.4% (3/125). The incidence of preterm birth before 37 weeks was 8.2% (8/97). Ninety-six (96.9%) of neonates were tested for SARS-CoV-2 viral nucleic acid on nasopharyngeal and pharyngeal samples and 16.67% (16/96) were resulted positive.Conclusions: At present, there is no evidence regarding the greater risk of pregnant women to succumb to COVID-19 infection and experience severe pneumonia. The risks of spontaneous abortion and preterm birth are not increased as reported in this study but shows possibility of vertical transmission when it manifests during the third trimester of pregnancy.

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The micronized progesterone in complex therapy of pregnant women with missed abortion in the anamnesis

Medical Council ◽

10.21518/2079-701x-2018-7-60-63 ◽

2018 ◽

pp. 60-63

Author(s):

I. V. Savelyeva ◽

O. V. Shirokova ◽

E. A. Bukharova ◽

I. B. Polyanskaya ◽

E. G. Galyanskaya ◽

...

Keyword(s):

Pregnant Women ◽

Missed Abortion ◽

Complex Therapy ◽

Micronized Progesterone

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Features of psychoemotional state of pregnant women with missed abortion in the early stages of pregnancy

PERINATOLOGIYA I PEDIATRIYA ◽

10.15574/pp.2016.66.40 ◽

2016 ◽

pp. 40-42

Author(s):

O.O. Bala ◽

◽

V.A. Benyuk ◽

T.V. Kovalyuk ◽

S.V. Benyuk ◽

...

Keyword(s):

Pregnant Women ◽

Missed Abortion ◽

Early Stages ◽

Psychoemotional State

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Prospective Study of Laminaria, Vaginal Misoprostol, and Mechanical Dilator Applications Before Surgical Intervention in First-trimester Pregnant Women with Missed Abortion

Erciyes Medical Journal ◽

10.5152/etd.2017.17060 ◽

2018 ◽

pp. 13-17

Author(s):

Savas Karakus ◽

◽

Serife Ozlem Genc ◽

Semih Uludag ◽

Bugra Oksasoglu ◽

...

Keyword(s):

Prospective Study ◽

Pregnant Women ◽

Surgical Intervention ◽

First Trimester ◽

Missed Abortion ◽

Vaginal Misoprostol

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Variations of serum copper values in pregnancy

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh1202042v ◽

2012 ◽

Vol 140 (1-2) ◽

pp. 42-46 ◽

Cited By ~ 15

Author(s):

Jelka Vukelic ◽

Aleksandra Kapamadzija ◽

Djordje Petrovic ◽

Zorica Grujic ◽

Aleksandra Novakov-Mikic ◽

...

Keyword(s):

Pregnant Women ◽

Serum Copper ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Missed Abortion ◽

Pathological Conditions ◽

Gestational Week ◽

The Mean ◽

In Pregnancy ◽

Made In

Introduction. Copper is essential micronutrient and has an important role in the human body. The serum copper increases during pregnancy and is doubled at full term. Lower levels of serum copper in pregnancy are connected with some pathological conditions. Objective. The aim of this study was to estimate the levels of serum copper in normal and pathological pregnancies, comparing them with values of serum copper in non-pregnant women, to determine if serum copper is lower in some pathological pregnancies and if this is of some importance. Methods. A total of 2170 plasma samples for copper analyses were made in the following groups: healthy non-pregnant women; healthy pregnant women from the 5th-40th gestational week, during the first delivery stage and during the first three postpartum weeks, in pregnant women with habitual abortion, imminent abortion, abortion in progress, missed abortion (9th-24th weeks), missed labour and premature rupture of membranes (29th-40th weeks). Levels of serum copper were determined by colorimetric technique of bathocuproin with disulphate as a chromogen. Results. Serum copper values in non-pregnant women range from 11.6-25.8 ?mol/L. In healthy pregnant women, there is a constant trend of the increase of serum copper. The mean serum copper values revealed three significant peaks at the 22nd, 27th and 35th gestational week. Serum copper values in the patients with some pathological pregnancies in relation to the serum copper values of the healthy pregnant women were significantly lower. Conclusion. Serum copper values can be used as an indicator of some pathological pregnancies.

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