Proton magnetic resonance spectroscopy in subjects with high genetic risk of schizophrenia: Investigation of anterior cingulate, dorsolateral prefrontal cortex and thalamus

2009 ◽  
Vol 111 (1-3) ◽  
pp. 86-93 ◽  
Author(s):  
So Young Yoo ◽  
Suran Yeon ◽  
Chi-Hoon Choi ◽  
Do-Hyung Kang ◽  
Jong-Min Lee ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Magnetic Resonance ◽  
Genetic Risk ◽  
Dorsolateral Prefrontal Cortex ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Anterior Cingulate ◽  
Resonance Spectroscopy ◽  
High Genetic Risk ◽  
Dorsolateral Prefrontal

Metabolic abnormality in the right dorsolateral prefrontal cortex in patients with obsessive–compulsive disorder: proton magnetic resonance spectroscopy

2016 ◽  
Vol 29 (3) ◽  
pp. 164-169 ◽  
Author(s):  
Shin-Eui Park ◽  
Nam-Gil Choi ◽  
Gwang-Woo Jeong
Keyword(s):  
Prefrontal Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Healthy Controls ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Dorsolateral Prefrontal ◽  
The Right

ObjectiveProton magnetic resonance spectroscopy (1H-MRS) was used to evaluate metabolic changes in the dorsolateral prefrontal cortex (DLPFC) in patients with obsessive–compulsive disorder (OCD).MethodsIn total, 14 OCD patients (mean age 28.9±7.2 years) and 14 healthy controls (mean age 32.6±7.1 years) with no history of neurological and psychiatric illness participated in this study. Brain metabolite concentrations were measured from a localised voxel on the right DLPFC using a 3-Tesla 1H-MRS.ResultsThe metabolic concentration of myo-inositol in patients with OCD increased significantly by 52% compared with the healthy controls, whereas glutamine/glutamate was decreased by 11%. However, there were no significant differences in N-acetylaspartate, choline, lactate and lipid between the two groups.ConclusionThese findings would be helpful to understand the pathophysiology of OCD associated with the brain metabolic abnormalities in the right DLPFC.

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