Altered asymmetry of the anterior cingulate cortex in subjects at genetic high risk for psychosis

2013 ◽  
Vol 150 (2-3) ◽  
pp. 512-518 ◽  
Author(s):  
Hye Youn Park ◽  
Jae Yeon Hwang ◽  
Wi Hoon Jung ◽  
Na Young Shin ◽  
Geumsook Shim ◽  
...  
2003 ◽  
Vol 182 (6) ◽  
pp. 518-524 ◽  
Author(s):  
Murat Yücel ◽  
Stephen J. Wood ◽  
Lisa J. Phillips ◽  
Geoffrey W. Stuart ◽  
Deidre J. Smith ◽  
...  

BackgroundThe anterior cingulate cortex (ACC) is consistently implicated in the pathophysiology of schizophrenia, and our own work has identified morphological anomalies in the ACC of people with this disorder.AimsTo examine whether ACC morphological anomalies are present in a group at ultra-high risk of psychosis and whether such anomalies can be used to predict the subsequent development of a psychotic illness.MethodMagnetic resonance imaging of 75 healthy volunteers and 63 people at ultra-high risk of developing a psychotic disorder (all right-handed males) was used to examine ACC sulcal and gyral features.ResultsCompared with the controls, significantly fewer people in the ultra-high risk group had a well-developed left paracingulate sulcus and significantly more had an interrupted left cingulate sulcus. There was no difference between those who did (n=21) and did not (n=42) subsequently develop a psychotic illness.ConclusionsAlthough ACC anomalies are present in young people considered to be at ultra-high risk of psychosis, they do not identify individuals who subsequently make the transition to psychosis.


2008 ◽  
Vol 64 (9) ◽  
pp. 758-765 ◽  
Author(s):  
Alex Fornito ◽  
Alison R. Yung ◽  
Stephen J. Wood ◽  
Lisa J. Phillips ◽  
Barnaby Nelson ◽  
...  

2012 ◽  
Vol 136 ◽  
pp. S298-S299
Author(s):  
Hvevoun Park ◽  
laeYeon Hwang ◽  
WiHoon Jung ◽  
Geumsook Shim ◽  
JoonHwan Jang ◽  
...  

2006 ◽  
Vol 37 (S 1) ◽  
Author(s):  
M Mannerkoski ◽  
H Heiskala ◽  
K Van Leemput ◽  
L Åberg ◽  
R Raininko ◽  
...  

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